Search Results - "Kuvalekar, Manik"

Allogeneic, off-the-shelf, SARS-CoV-2-specific T cells (ALVR109) for the treatment of COVID-19 in high-risk patients by Vasileiou, Spyridoula, Hill, LaQuisa, Kuvalekar, Manik, Workineh, Aster G, Watanabe, Ayumi, Velazquez, Yovana, Lulla, Suhasini, Mooney, Kimberly, Lapteva, Natalia, Grilley, Bambi J, Heslop, Helen E, Rooney, Cliona M, Brenner, Malcolm K, Eagar, Todd N, Carrum, George, Grimes, Kevin A, Leen, Ann M, Lulla, Premal

“…Defects in T-cell immunity to SARS-CoV-2 have been linked to an increased risk of severe COVID-19 (even after vaccination), persistent viral shedding and the…”
Get full text

Longitudinal analysis of the evolution of cellular immunity to SARS-CoV-2 induced by infection and vaccination by Vasileiou, Spyridoula, Kuvalekar, Manik, Velazquez, Yovana, Watanabe, Ayumi, Narula, Mansi, Workineh, Aster G, French-Kim, Matthew, Chavez, Alejandro Torres, Gilmore, Sarah, Rooney, Cliona M, Leen, Ann M

Get full text

Rapid generation of multivirus-specific T lymphocytes for the prevention and treatment of respiratory viral infections by Vasileiou, Spyridoula, Turney, Anne M, Kuvalekar, Manik, Mukhi, Shivani S, Watanabe, Ayumi, Lulla, Premal, Ramos, Carlos A, Naik, Swati, Vera, Juan F, Tzannou, Ifigeneia, Leen, Ann M

Get full text

Assessment of the cytolytic potential of a multivirus-targeted T cell therapy using a vital dye-based, flow cytometric assay by Koukoulias, Kiriakos, Papayanni, Penelope G, Jones, Julia, Kuvalekar, Manik, Watanabe, Ayumi, Velazquez, Yovana, Gilmore, Sarah, Papadopoulou, Anastasia, Leen, Ann M, Vasileiou, Spyridoula

“…Reliable and sensitive characterization assays are important determinants of the successful clinical translation of immunotherapies. For the assessment of…”
Get full text

Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer by Hoyos, Valentina, Vasileiou, Spyridoula, Kuvalekar, Manik, Watanabe, Ayumi, Tzannou, Ifigeneia, Velazquez, Yovana, French-Kim, Matthew, Leung, Wingchi, Lulla, Suhasini, Robertson, Catherine, Foreman, Claudette, Wang, Tao, Bulsara, Shaun, Lapteva, Natalia, Grilley, Bambi, Ellis, Matthew, Osborne, Charles Kent, Coscio, Angela, Nangia, Julie, Heslop, Helen E., Rooney, Cliona M., Vera, Juan F., Lulla, Premal, Rimawi, Mothaffar, Leen, Ann M.

“…Purpose: Adoptively transferred, ex vivo expanded multi-antigen-targeted T cells (multiTAA-T) represent a new, potentially effective, and nontoxic therapeutic…”
Get full text

“Mini” bank of only 8 donors supplies CMV-directed T cells to diverse recipients by Tzannou, Ifigeneia, Watanabe, Ayumi, Naik, Swati, Daum, Rachel, Kuvalekar, Manik, Leung, Kathryn S., Martinez, Caridad, Sasa, Ghadir, Wu, Mengfen, Gee, Adrian P., Krance, Robert A., Gottschalk, Stephen, Heslop, Helen E., Omer, Bilal

“…Cytomegalovirus (CMV) infections remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT), and standard…”
Get full text

Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation by Tzannou, Ifigeneia, Papadopoulou, Anastasia, Naik, Swati, Leung, Kathryn, Martinez, Caridad A, Ramos, Carlos A, Carrum, George, Sasa, Ghadir, Lulla, Premal, Watanabe, Ayumi, Kuvalekar, Manik, Gee, Adrian P, Wu, Meng-Fen, Liu, Hao, Grilley, Bambi J, Krance, Robert A, Gottschalk, Stephen, Brenner, Malcolm K, Rooney, Cliona M, Heslop, Helen E, Leen, Ann M, Omer, Bilal

“…Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will require efforts to decrease…”
Get full text

Immune Profiling of Respiratory Syncytial Virus (RSV) for the Development of Targeted Immunotherapy by Papayanni, Penelope, Koukoulias, Kiriakos, Kuvalekar, Manik, Watanabe, Ayumi, Velazquez, Yovana, Ramos, Carlos A., Leen, Ann M., Vasileiou, Spyridoula

“…Introduction: RSV-associated respiratory viral infections are a major public health problem affecting the immunologically naïve/compromised population. For…”
Get full text

Phenotypic and functional characterization of posoleucel, a multivirus-specific T cell therapy for the treatment and prevention of viral infections in immunocompromised patients by Vasileiou, Spyridoula, Kuvalekar, Manik, Velazquez, Yovana, Watanabe, Ayumi, Leen, Ann M., Gilmore, Sarah A.

“…Deficits in T cell immunity translate into increased risk of severe viral infection in recipients of solid organ and hematopoietic cell transplants. Thus,…”
Get full text

Exploring hepatitis B virus as an immunotherapeutic target for clinical trials of adoptively transferred T cells by Lulla, Suhasini, Chang, Tsung-Yen, Vasileiou, Spyridoula, Kuvalekar, Manik, Watanabe, Ayumi, Velazquez, Yovana, Stanton, Jenny, Leen, Ann

Get full text

T cell immune profiling of respiratory syncytial virus for the development of a targeted immunotherapy by Papayanni, Penelope Georgia, Koukoulias, Kiriakos, Kuvalekar, Manik, Watanabe, Ayumi, Velazquez, Yovana, Ramos, Carlos A., Leen, Ann M., Vasileiou, Spyridoula

“…Summary Respiratory syncytial virus (RSV)‐associated viral infections are a major public health problem affecting the immunologically naïve/compromised…”
Get full text

Clinical effects of administering leukemia-specific donor T cells to patients with AML/MDS after allogeneic transplant by Lulla, Premal D., Naik, Swati, Vasileiou, Spyridoula, Tzannou, Ifigeneia, Watanabe, Ayumi, Kuvalekar, Manik, Lulla, Suhasini, Carrum, George, Ramos, Carlos A., Kamble, Rammurti, Hill, LaQuisa, Randhawa, Jasleen, Gottschalk, Stephen, Krance, Robert, Wang, Tao, Wu, Mengfen, Robertson, Catherine, Gee, Adrian P., Chung, Betty, Grilley, Bambi, Brenner, Malcolm K., Heslop, Helen E., Vera, Juan F., Leen, Ann M.

“…Relapse after allogeneic hematopoietic stem cell transplantation (HCT) is the leading cause of death in patients with acute myeloid leukemia (AML) or…”
Get full text

Targeting IDH2R140Q and other neoantigens in acute myeloid leukemia by Leung, Wingchi K., Torres Chavez, Alejandro G., French-Kim, Matthew, Shafer, Paul, Mamonkin, Maksim, Hill, LaQuisa C., Kuvalekar, Manik, Velazquez, Yovana, Watanabe, Ayumi, Watanabe, Norihiro, Hoyos, Valentina, Lulla, Premal, Leen, Ann M.

“…•Neoantigens arising from recurrent AML mutations are immunogenic and represent novel immunotherapeutic targets.•IDH2R140Q-specific T cells can selectively…”
Get full text

T-Cell Therapy for Lymphoma Using Nonengineered Multiantigen-Targeted T Cells Is Safe and Produces Durable Clinical Effects by Vasileiou, Spyridoula, Lulla, Premal D, Tzannou, Ifigeneia, Watanabe, Ayumi, Kuvalekar, Manik, Callejas, Wendy L, Bilgi, Mrinalini, Wang, Tao, Wu, Mengfen J, Kamble, Rammurti, Ramos, Carlos A, Rouce, Rayne H, Zeng, Zihua, Gee, Adrian P, Grilley, Bambi J, Vera, Juan F, Bollard, Catherine M, Brenner, Malcolm K, Heslop, Helen E, Rooney, Cliona M, Leen, Ann M, Carrum, George

“…Patients with relapsed lymphomas often fail salvage therapies including high-dose chemotherapy and mono-antigen-specific T-cell therapies, highlighting the…”
Get full text

Donor-derived multiple leukemia antigen–specific T-cell therapy to prevent relapse after transplant in patients with ALL by Naik, Swati, Vasileiou, Spyridoula, Tzannou, Ifigeneia, Kuvalekar, Manik, Watanabe, Ayumi, Robertson, Catherine, Lapteva, Natalia, Tao, Wang, Wu, Mengfen, Grilley, Bambi, Carrum, George, Kamble, Rammurti T., Hill, LaQuisa, Krance, Robert A., Martinez, Caridad, Tewari, Priti, Omer, Bilal, Gottschalk, Stephen, Heslop, Helen E., Brenner, Malcom K., Rooney, Cliona M., Vera, Juan F., Leen, Ann M., Lulla, Premal D.

“…Hematopoietic stem cell transplant (HSCT) is a curative option for patients with high-risk acute lymphoblastic leukemia (ALL), but relapse remains a major…”
Get full text

Treatment of Severe, Drug-Refractory Viral Infections with Allogeneic, Off-the-Shelf Multi-Virus Specific T Cells in Patients Following HSCT: Results from a Phase 2 Study by Tzannou, Ifigeneia, Watanabe, Ayumi, Papadopoulou, Anastasia, Kuvalekar, Manik, Naik, Swati, Lulla, Premal, Krance, Robert A., Ramos, Carlos A., Heslop, Helen E., Leen, Ann M., Omer, Bilal

“…▪ Background. Serious viral infections associated with delayed immune reconstitution are a leading cause of morbidity and mortality after allogeneic…”
Get full text

Phenotypic and Functional Characterization of Posoleucel, a Multivirus-Specific T Cell Therapy for the Treatment and Prevention of Viral Infections in Immunocompromised Patients by Vasileiou, Spyridoula, Kuvalekar, Manik, Velazquez, Yovana, Watanabe, Ayumi, Leen, Ann M., Gilmore, Sarah

“…Severe viral infections are a significant problem for immunocompromised patients such as recipients of allogeneic hematopoietic cell (HCT) or solid organ (SOT)…”
Get full text

Using Allogeneic, Off-the-Shelf, Sars-Cov-2-Specific T Cells to Treat High Risk Patients with COVID-19 by Vasileiou, Spyridoula, Kuvalekar, Manik, Workineh, Aster, Watanabe, Ayumi, Velazquez, Yovana, Lulla, Suhasini, Heslop, Helen E., Mooney, Kimberly, Grimes, Kevin, Carrum, George, Hill, LaQuisa C., Lulla, Premal, Leen, Ann M.

“…Background. On 11 March, 2020 the World Health Organization declared COVID-19, caused by SARS-CoV-2, a global pandemic with almost 17,000,000 confirmed cases…”
Get full text

Donor-Derived Adoptive T-Cell Therapy Targeting Multiple Tumor Associated Antigens to Prevent Post-Transplant Relapse in Patients with ALL by Naik, Swati, Vasileiou, Spyridoula, Tzannou, Ifigeneia, Kuvalekar, Manik, Watanabe, Ayumi, Robertson, Catherine, Gee, Adrian P., Grilley, Bambi J., Carrum, George, Kamble, Rammurti, Hill, LaQuisa C., Krance, Robert A., Martinez, Caridad A., Omer, Bilal, Gottschalk, Stephen, Heslop, Helen E., Rooney, Cliona M., Vera, Juan, Leen, Ann, Lulla, Premal D.

“…Background: Hematopoietic stem cell transplant (HSCT) is a curative option for patients with high-risk Acute Lymphoblastic Leukemia (HR-ALL), but relapse…”
Get full text

Rapid Generation of Multivirus-Specific T Lymphocytes for the Prevention and Treatment of Respiratory Viral Infections by Vasileiou, Spyridoula, Turney, Annie, Kuvalekar, Manik, Mukhi, Shivani, Watanabe, Ayumi, Lulla, Premal, Ramos, Carlos A., Vera, Juan, Tzannou, Ifigeneia, Leen, Ann

“…▪ Acute upper and lower respiratory tract infections (RTIs) due to community-acquired respiratory viruses (CARVs) including respiratory syncytial virus (RSV),…”
Get full text