Search Results - "Kuukasjarvi, T"

Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy by Kuukasjärvi, T, Kononen, J, Helin, H, Holli, K, Isola, J

“…Up to 30% to 40% of metastases from hormone receptor-positive primary breast cancer do not respond to endocrine therapy. We studied how often hormone receptor…”
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Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer by KUUKASJÄRVI, T, KARHU, R, TANNER, M, KÄHKÖNEN, M, SCHÄFFER, A, NUPPONEN, N, PENNANEN, S, KALLIONIEMI, A, KALLIONIEMI, O.-P, ISOLA, J

“…To understand the genetic basis and clonal evolution underlying metastatic progression of human breast cancer in vivo, we analyzed the genetic composition of…”
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Predictive value of topoisomerase IIα and other prognostic factors for epirubicin chemotherapy in advanced breast cancer by JÄRVINEN, T. A. H, HOLLI, K, KUUKASJÄRVI, T, ISOLA, J. J

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The impact of lobular and ductal breast cancer histology on the metastatic behavior and long term survival of breast cancer patients by Korhonen, T, Kuukasjärvi, T, Huhtala, H, Alarmo, E.-L, Holli, K, Kallioniemi, A, Pylkkänen, L

“…Abstract The aim of the study was to evaluate the long-term survival of patients with invasive lobular carcinomas (ILC) and invasive ductal carcinomas (IDC)…”
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Dynamic infrared imaging in identification of breast cancer tissue with combined image processing and frequency analysis by Joro, R., Lääperi, A.-L., Soimakallio, S., Järvenpää, R., Kuukasjärvi, T., Toivonen, T., Saaristo, R., Dastidar, P.

“…Five combinations of image-processing algorithms were applied to dynamic infrared (IR) images of six breast cancer patients preoperatively to establish optimal…”
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Genetic changes in intraductal breast cancer detected by comparative genomic hybridization by Kuukasjarvi, T, Tanner, M, Pennanen, S, Karhu, R, Kallioniemi, OP, Isola, J

“…Ductal carcinoma in situ (DCIS) is considered a direct precursor of invasive ductal breast cancer (IDC). We combined tissue microdissection and comparative…”
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Imaging of breast cancer with mid- and long-wave infrared camera by Joro, R., Lääperi, A.-L., Dastidar, P., Soimakallio, S., Kuukasjärvi, T., Toivonen, T., Saaristo, R., Järvenpää, R.

“…In this novel study the breasts of 15 women with palpable breast cancer were preoperatively imaged with three technically different infrared (IR) cameras-micro…”
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Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer by TANNER, M. M, TIRKKONEN, M, MELTZER, P, KALLIONEIMI, O. P, KALLIONEIMI, A, ISOLA, J, KUUKASJÄRVI, T, COLLINS, C, KOWBEL, D, GUAN, X.-Y, TRENT, J, GRAY, J. W

“…DNA amplification at 20q13.2 is common in breast cancer, correlates with poor prognosis, and may reflect location of an important oncogene. Recently, other…”
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145 A rescoring of Elston-Ellis Grade improves prognostic discrimination and consistency by Blamey, R, Hornmark-Stenstam, B, Bianchi, S, Kuukasjarvi, T, Pinder, S, Rank, F, Ball, G, Ellis, I

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O-71 Rescoring of grade and re-evaluation of the Nottingham Prognostic Index (NPI) using components of Elston Ellis grade and adding lympho-vascular invasion by Blamey, R.W, Ball, G.R, Lee, A.H.S, Bianci, S, Green, A, Hornmark-Stanstam, B, Kuukasjarvi, T, Pinder, S, Rank, F, Ellis, I.O

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High-level amplification at 17q23 leads to coordinated overexpression of multiple adjacent genes in breast cancer by PARSSINEN, J, KUUKASJÄRVI, T, KARHU, R, KALLIONIEMI, A

“…Increased copy numbers of 17q23 chromosomal region have been shown to occur in different tumour types and to be associated with tumour progression and with…”
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Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas by Alarmo, E.-L., Korhonen, T., Kuukasjärvi, T., Huhtala, H., Holli, K., Kallioniemi, A.

“…Background: We recently showed that bone morphogenetic protein 7 (BMP7) is overexpressed in primary breast tumors. Here we explored the clinical significance…”
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Genetic changes in familial prostate cancer by comparative genomic hybridization by Rökman, Annika, Koivisto, Pasi A., Matikainen, Mika P., Kuukasjärvi, Tuula, Poutiainen, Marita, Helin, Heikki J., Karhu, Ritva, Kallioniemi, Olli-P., Schleutker, Johanna

“…Background Germline mutations in recessive cancer predisposition genes are uncovered by somatic genetic deletions during tumor development. Analysis of genetic…”
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A dynamic infrared imaging-based diagnostic process for breast cancer by Joro, R, Lääperi, A-L, Dastidar, P, Järvenpää, R, Kuukasjärvi, T, Toivonen, T, Saaristo, R, Soimakallio, S

“…Dynamic infrared (IR) imaging is an emerging functional imaging modality for the detection of breast cancer without evidence of optimal imaging and diagnostic…”
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Amplification of a 280-Kilobase Core Region at the ERBB2 Locus Leads to Activation of Two Hypothetical Proteins in Breast Cancer by Kauraniemi, Päivikki, Kuukasjärvi, Tuula, Sauter, Guido, Kallioniemi, Anne

“…Amplification of the ERBB2 oncogene at 17q12 is clinically the most relevant genetic aberration in breast cancer and several studies have linked ERBB2…”
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The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours by RAUTA, Jenita, ALARMO, Emma-Leena, KAURANIEMI, Päivikki, KARHU, Ritva, KUUKASJÄRVI, Tuula, KALLIONIEMI, Anne

“…The serine-threonine protein phosphatase PPM1D is likely to play an important role in tumorigenesis. Through inactivation of p38 MAPK, PPM1D acts as a negative…”
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Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer by Alarmo, Emma-Leena, Rauta, Jenita, Kauraniemi, Päivikki, Karhu, Ritva, Kuukasjärvi, Tuula, Kallioniemi, Anne

“…Bone morphogenetic proteins (BMP) make up a family of extracellular signaling molecules that play a critical role in vertebrate development and both inhibit…”
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Androgen receptor amplification is associated with increased cell proliferation in prostate cancer by Haapala, Kyllikki, MSc, Kuukasjärvi, Tuula, MD, PhD, Hyytinen, Eija, PhD, Rantala, Immo, PhD, Helin, Heikki J., MD, PhD, Koivisto, Pasi A., MD, PhD

“…Summary Mechanisms of prostate cancer progression during hormonal therapy and the pathobiologic consequences of androgen receptor ( AR ) gene amplification are…”
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CHEK2 1100delC is not a risk factor for male breast cancer population by Syrjäkoski, Kirsi, Kuukasjärvi, Tuula, Auvinen, Anssi, Kallioniemi, Olli‐P

“…Genetic risk factors for male breast cancer (MBC) are poorly understood. High penetrance genes such as BRCA1 or BRCA2 account for only a small proportion of…”
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Frequent amplification and overexpression of CCND1 in male breast cancer by Bärlund, Maarit, Kuukasjärvi, Tuula, Syrjäkoski, Kirsi, Auvinen, Anssi, Kallioniemi, Anne

“…Genetic events underlying the pathogenesis of breast cancer have been studied extensively and several clinically significant markers have been identified. For…”
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