Search Results - "Kuukasjärvi, Tuula"

The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours by RAUTA, Jenita, ALARMO, Emma-Leena, KAURANIEMI, Päivikki, KARHU, Ritva, KUUKASJÄRVI, Tuula, KALLIONIEMI, Anne

“…The serine-threonine protein phosphatase PPM1D is likely to play an important role in tumorigenesis. Through inactivation of p38 MAPK, PPM1D acts as a negative…”
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Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer by Alarmo, Emma-Leena, Rauta, Jenita, Kauraniemi, Päivikki, Karhu, Ritva, Kuukasjärvi, Tuula, Kallioniemi, Anne

“…Bone morphogenetic proteins (BMP) make up a family of extracellular signaling molecules that play a critical role in vertebrate development and both inhibit…”
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Androgen receptor amplification is associated with increased cell proliferation in prostate cancer by Haapala, Kyllikki, MSc, Kuukasjärvi, Tuula, MD, PhD, Hyytinen, Eija, PhD, Rantala, Immo, PhD, Helin, Heikki J., MD, PhD, Koivisto, Pasi A., MD, PhD

“…Summary Mechanisms of prostate cancer progression during hormonal therapy and the pathobiologic consequences of androgen receptor ( AR ) gene amplification are…”
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Frequent amplification and overexpression of CCND1 in male breast cancer by Bärlund, Maarit, Kuukasjärvi, Tuula, Syrjäkoski, Kirsi, Auvinen, Anssi, Kallioniemi, Anne

“…Genetic events underlying the pathogenesis of breast cancer have been studied extensively and several clinically significant markers have been identified. For…”
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A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7 by ALARMO, Emma-Leena, KUUKASJÄRVI, Tuula, KARHU, Ritva, KALLIONIEMI, Anne

“…Bone morphogenetic proteins (BMPs) regulate diverse cellular processes, such as proliferation, differentiation, and apoptosis. The BMPs have been studied in…”
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Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development by Alarmo, Emma-Leena, Huhtala, Heini, Korhonen, Tarja, Pylkkänen, Liisa, Holli, Kaija, Kuukasjärvi, Tuula, Parkkila, Seppo, Kallioniemi, Anne

“…Bone morphogenetic proteins (BMPs) are extracellular signaling molecules that belong to the transforming growth factor β (TGF β ) superfamily and are known to…”
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BRCA2 Mutations in 154 Finnish Male Breast Cancer Patients by Syrjäkoski, Kirsi, Kuukasjärvi, Tuula, Waltering, Kati, Haraldsson, Karin, Auvinen, Anssi, Borg, Åke, Kainu, Tommi, Kallioniemi, Olli-P, Koivisto, Pasi A.

“…The etiology and pathogenesis of male breast cancer (MBC) are poorly known. This is due to the fact that the disease is rare, and large-scale genetic…”
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Amplification of a 280-Kilobase Core Region at the ERBB2 Locus Leads to Activation of Two Hypothetical Proteins in Breast Cancer by Kauraniemi, Päivikki, Kuukasjärvi, Tuula, Sauter, Guido, Kallioniemi, Anne

“…Amplification of the ERBB2 oncogene at 17q12 is clinically the most relevant genetic aberration in breast cancer and several studies have linked ERBB2…”
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Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer by KUUKASJÄRVI, T, KARHU, R, TANNER, M, KÄHKÖNEN, M, SCHÄFFER, A, NUPPONEN, N, PENNANEN, S, KALLIONIEMI, A, KALLIONIEMI, O.-P, ISOLA, J

“…To understand the genetic basis and clonal evolution underlying metastatic progression of human breast cancer in vivo, we analyzed the genetic composition of…”
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Somatic Deletions in Hereditary Breast Cancers Implicate 13q21 as a Putative Novel Breast Cancer Susceptibility Locus by Kainu, Tommi, Juo, Suh-Hang Hank, Desper, Richard, Schaffer, Alejandro A., Gillanders, Elizabeth, Rozenblum, Ester, Freas-Lutz, Diana, Weaver, Don, Stephan, Dietrich, Bailey-Wilson, Joan, Olli-P. Kallioniemi, Trikkonen, Mika, Syrjakoski, Kirsi, Kuukasjarvi, Tuula, Koivisto, Pasi, Karhu, Ritva, Holli, Kaija, Arason, Adalgeir, Johannesdottir, Gudrun, Bergthorsson, Jon Thor, Johannsdottir, Hrefna, Egilsson, Valgardur, Barkardottir, Rosa Bjork, Johannsson, Oskar, Haraldsson, Karin, Sandberg, Therese, Holmberg, Eva, Gronberg, Henrik, Olsson, Hakan, Borg, Ake, Vehmanen, Paula, Eerola, Hannaleena, Heikkila, Paivi, Pyrhonen, Seppo, Nevanlinna, Heli

“…A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We applied a strategy to identify…”
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Hemochromatosis gene mutations among Finnish male breast and prostate cancer patients by Syrjäkoski, Kirsi, Fredriksson, Henna, Ikonen, Tarja, Kuukasjärvi, Tuula, Autio, Ville, Matikainen, Mika P., Tammela, Teuvo L.J., Koivisto, Pasi A., Schleutker, Johanna

“…Hereditary hemochromatosis (HH), the most common genetic disease in northern Europeans, is an autosomal recessive disorder of iron metabolism. The association…”
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Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer by TANNER, M. M, TIRKKONEN, M, MELTZER, P, KALLIONEIMI, O. P, KALLIONEIMI, A, ISOLA, J, KUUKASJÄRVI, T, COLLINS, C, KOWBEL, D, GUAN, X.-Y, TRENT, J, GRAY, J. W

“…DNA amplification at 20q13.2 is common in breast cancer, correlates with poor prognosis, and may reflect location of an important oncogene. Recently, other…”
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Genetic changes in intraductal breast cancer detected by comparative genomic hybridization by Kuukasjarvi, T, Tanner, M, Pennanen, S, Karhu, R, Kallioniemi, OP, Isola, J

“…Ductal carcinoma in situ (DCIS) is considered a direct precursor of invasive ductal breast cancer (IDC). We combined tissue microdissection and comparative…”
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Androgen receptor gene alterations in finnish male breast cancer by SYRJÄKOSKI, Kirsi, HYYTINEN, Eija-R, KUUKASJÄRVI, Tuula, AUVINEN, Anssi, KALLIONIEMI, Olli-P, KAINU, Tommi, KOIVISTO, Pasi A

“…Mutations in the androgen receptor (AR) gene have been suggested to predispose to male breast cancer (MBC). Studies on MBC patients have not been based on the…”
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CHEK2 1100delC is not a risk factor for male breast cancer population by Syrjäkoski, Kirsi, Kuukasjärvi, Tuula, Auvinen, Anssi, Kallioniemi, Olli‐P

“…Genetic risk factors for male breast cancer (MBC) are poorly understood. High penetrance genes such as BRCA1 or BRCA2 account for only a small proportion of…”
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Optimizing DOP-PCR for universal amplification of small DNA samples in comparative genomic hybridization by Kuukasjärvi, Tuula, Tanner, Minna, Pennanen, Sari, Karhu, Ritva, Visakorpi, Tapio, Isola, Jorma

“…The standard comparative genomic hybridization (CGH) protocol relies on availability of macroscopic tumor samples, which do not contain too much interfering…”
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BRCA2 Mutations in 154 Finnish Male Breast Cancer Patients1 by Syrjäkoski, Kirsi, Kuukasjärvi, Tuula, Waltering, Kati, Haraldsson, Karin, Auvinen, Anssi, Borg, Åke, Kainu, Tommi, Kallioniemi, Olli-P, Koivisto, Pasi A

“…The etiology and pathogenesis of male breast cancer (MBC) are poorly known. This is due to the fact that the disease is rare, and large-scale genetic…”
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Genetic changes in familial prostate cancer by comparative genomic hybridization by Rökman, Annika, Koivisto, Pasi A., Matikainen, Mika P., Kuukasjärvi, Tuula, Poutiainen, Marita, Helin, Heikki J., Karhu, Ritva, Kallioniemi, Olli-P., Schleutker, Johanna

“…Background Germline mutations in recessive cancer predisposition genes are uncovered by somatic genetic deletions during tumor development. Analysis of genetic…”
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Quality control of CGH: Impact of metaphase chromosomes and the dynamic range of hybridization by Karhu, Ritva, Kähkönen, Marketta, Kuukasjärvi, Tuula, Pennanen, Sari, Tirkkonen, Mika, Kallioniemi, Olli

“…With the recent rapid expansion in the use of the comparative genomic hybridization (CGH) technique, increased attention to quality control is essential. In…”
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