Search Results - "Kutuk, Ozgur"

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance by Kale, Justin, Kutuk, Ozgur, Brito, Glauber Costa, Andrews, Tallulah S, Leber, Brian, Letai, Anthony, Andrews, David W

“…Akt is a pro‐survival kinase frequently activated in human cancers and is associated with more aggressive tumors that resist therapy. Here, we connect Akt…”
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Regulation of Bcl-2 family proteins by posttranslational modifications by Kutuk, Ozgur, Letai, Anthony

“…Like many proteins, function and abundance of Bcl-2 family proteins are influenced by posttranslational modifications. These modifications include…”
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Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells by Kutuk, Ozgur, Aytan, Nurgul, Karakas, Bahriye, Kurt, Asli Giray, Acikbas, Ufuk, Temel, Sehime Gulsun, Basaga, Huveyda

“…Necrosis, apoptosis and autophagic cell death are the main cell death pathways in multicellular organisms, all with distinct and overlapping cellular and…”
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Cytokine expression profiles in children and adolescents with tic disorders by Kutuk, Meryem Ozlem, Tufan, Ali Evren, Kilicaslan, Fethiye, Gokcen, Cem, Aksu, Gulen Guler, Yektas, Cigdem, Kandemir, Hasan, Celik, Fatma, Mutluer, Tuba, Buber, Ahmet, Karadag, Mehmet, Coban, Nurdan, Coskun, Seyma, Hangul, Zehra, Altintas, Ebru, Acikbas, Ufuk, Giray, Asli, Aka, Yeliz, Basturk, Bilkay, Kutuk, Ozgur

“…The etiology of tic disorders (TDs) is not precisely known, although several lines of evidence suggest involvement of the immune system in pathogenesis. Here,…”
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Migraine and associated comorbidities are three times more frequent in children with ADHD and their mothers by Kutuk, Meryem Ozlem, Tufan, Ali Evren, Guler, Gulen, Yalin, Osman Ozgur, Altintas, Ebru, Bag, Harika Gozukara, Uluduz, Derya, Toros, Fevziye, Aytan, Nurgul, Kutuk, Ozgur, Ozge, Aynur

“…Attention deficit and hyperactivity disorder (ADHD) is a neuro-developmental disorder related to internalizing and externalizing disorders as well as somatic…”
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RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells by Temel, Sehime Gulsun, Giray, Aslı, Karakas, Bahriye, Gul, Ozgur, Kozanoglu, Ilknur, Celik, Husnu, Basaga, Huveyda, Acikbas, Ufuk, Sucularli, Ceren, Oztop, Sidika, Aka, Yeliz, Kutuk, Ozgur

“…Ovarian cancer remains one of the most frequent causes of cancer-related death in women. Many patients with ovarian cancer suffer from de novo or acquired…”
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Editorial: Cell Death and Targeted Cancer Therapies by Bagci-Onder, Tugba, Kutuk, Ozgur, Chonghaile, Triona Ni, Knippschild, Uwe

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Mitochondrial estrogen receptors alter mitochondrial priming and response to endocrine therapy in breast cancer cells by Karakas, Bahriye, Aka, Yeliz, Giray, Asli, Temel, Sehime Gulsun, Acikbas, Ufuk, Basaga, Huveyda, Gul, Ozgur, Kutuk, Ozgur

“…Breast cancer is the most common cancer with a high rate of mortality and morbidity among women worldwide. Estrogen receptor status is an important prognostic…”
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Bcl-2 protein family: implications in vascular apoptosis and atherosclerosis by Kutuk, Ozgur, Basaga, Huveyda

“…Apoptosis has been recognized as a central component in the pathogenesis of atherosclerosis, in addition to the other human pathologies such as cancer and…”
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Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling by Bodur, Cagri, Kutuk, Ozgur, Karsli-Uzunbas, Gizem, Isimjan, Tayirjan T, Harrison, Paul, Basaga, Huveyda

“…Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We…”
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Hiccup Due to Aripiprazole Plus Methylphenidate Treatment in an Adolescent with Attention Deficit and Hyperactivity Disorder and Conduct Disorder: A Case Report by Kutuk, Meryem Ozlem, Guler, Gulen, Tufan, Ali Evren, Kutuk, Ozgur

“…Our case had hiccups arising in an adolescent with the attention deficit and hyperactivity disorder (ADHD) and conduct disorder (CD) after adding aripiprazole…”
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Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells by Arisan, Elif Damla, Kutuk, Ozgur, Tezil, Tugsan, Bodur, Cagri, Telci, Dilek, Basaga, Huveyda

“…Inhibition or downregulation of Bcl-2 represents a new therapeutic approach to by-pass chemoresistance in cancer cells. Therefore, we explored the potential of…”
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Functional outcome in late adolescence/early adulthood of patients with autism spectrum disorder and its relationships with parental burnout and depression: A preliminary multi-center, cross-sectional study by Kutuk, Meryem Ozlem, Tufan, Ali Evren, Kilicaslan, Fethiye, Vural, Pınar, Gokcen, Cem, Alsen Guney, Sevay, Kutuk, Bahtim, Ozyurt, Gonca, Inal, Neslihan, Mutluer, Tuba, Acikalin, Eren Yavuz, Ozer, Fadime Hande, Pamuk, Esma Nur, Yesilmese, Seyma Celikcan, Karadag, Mehmet, Hangul, Zehra, Bilginer, Cilem, Sahin, Nilfer, Bilac, Oznur, Kandemir, Hasan, Ercan, Eyup Sabri, Eseroglu Soylemez, Tugba, Acikel, Sadettin Burak, Guler Aksu, Gulen, Dag, Pelin, Toros, Fevziye, Mutlu, Caner, Kardas, Omer, Kardas, Burcu, Kizildag, Suleyman, Demirci, Esra, Ozmen, Sevgi, Sevicin, Leyla, Karagoz, Yuksel Sumeyra, Isik, Umit, Aktepe, Evrim, Altun, Hatice, Yektas, Çigdem, Polat Tuysuz, Berna, Buber, Ahmet, Cansiz, Mehmet Akif, Ogutlu, Hakan, Eray, Safak, Taner, Hande Ayraler, Altintas, Ebru, Kutuk, Ozgur

“…The aim of this study is to determine the functioning of adults with autism spectrum disorders (ASDs) diagnosed in childhood and depression and burnout levels…”
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Resveratrol Protects Against 4-Hydroxynonenal-Induced Apoptosis by Blocking JNK and c-JUN/AP-1 Signaling by Kutuk, Ozgur, Poli, Giuseppe, Basaga, Huveyda

“…In the present study we have studied the effect of resveratrol in signal transduction mechanisms leading to apoptosis in 3T3 fibroblasts when exposed to…”
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Evaluating clonidine response in children and adolescents with attention-deficit/hyperactivity disorder by Ozlem Kutuk, Meryem, Guler, Gulen, Evren Tufan, Ali, Ali Sungur, Mehmet, Topal, Zehra, Kutuk, Ozgur

“…Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood, which is generally treated with stimulant and…”
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Alteration of the Mitochondrial Apoptotic Pathway Is Key to Acquired Paclitaxel Resistance and Can Be Reversed by ABT-737 by KUTUK, Ozgur, LETAI, Anthony

“…Paclitaxel is a microtubule-targeting antineoplastic drug widely used in human cancers. Even when tumors are initially responsive, progression of disease…”
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Selective targeting of antiapoptotic BCL‐2 proteins in cancer by Timucin, Ahmet Can, Basaga, Huveyda, Kutuk, Ozgur

“…Circumvention of apoptotic machinery is one of the distinctive properties of carcinogenesis. Extensively established key effectors of such apoptotic bypass…”
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P.030: Evaluation of relationship between CD68-positive macrophages and clinical and laboratory parameters in kidney transplant recipients who experienced transplant kidney biopsy by Sayin, Burak, Terzi, Aysen, Handan Ozdemir, B., Kutuk, Ozgur, Colak, Turan, Karakaya, Emre, Haberal, Mehmet A.

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Novel pyrrolopyrimidine derivatives induce p53-independent apoptosis via the mitochondrial pathway in colon cancer cells by Kilic-Kurt, Zühal, Aka, Yeliz, Kutuk, Ozgur

“…A series of novel pyrrolopyrimidine urea derivatives were synthesized and evaluated for their anticancer activity against colon cancer cell lines. Compounds…”
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The mechanism of anticancer effects of some pyrrolopyrimidine derivatives on HT-29 human colon cancer cells by Ergul, Mustafa, Kilic-Kurt, Zuhal, Aka, Yeliz, Kutuk, Ozgur, Sahin-Inan, Zeynep Deniz

“…In the present work, the mechanism of anticancer activity of some pyrrolopyrimidine derivatives was evaluated. Compounds 5 and 8 exhibiting significant…”
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