Down regulation of serum protein expression in oral submucous fibrosis: A proteomic study

Background: Oral submucous fibrosis (OSMF) is a potentially malignant condition, which affects the oral cavity and the oropharynx. Despite the high prevalence rates of the disease and the morbidity and mortality related to the malignant transformation of 3%-19%, that is, OSMF into oral squamous cell...

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Bibliographic Details
Published in:	Journal of Indian Academy of Oral Medicine and Radiology Vol. 30; no. 3; pp. 207 - 209
Main Authors:	Mathew, Nimi, Shenoy, Prashanth, Chatra, Laxmikanth, Veena, K, Prabhu, Rachana, Kuttappa, Tashika
Format:	Journal Article
Language:	English
Published:	Mumbai Wolters Kluwer India Pvt. Ltd 01-07-2018 Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications
Subjects:	Apolipoproteins Biomarkers Biopsy Blood proteins Body fluid proteomics Cholesterol Chromatography Development and progression Diagnosis Fibrosis Health aspects Lipids Lipoproteins Mass spectrometry Medical research Metabolism Morbidity Mouth diseases OFFGEL electrophoresis Oral cancer Oral cavity Oral squamous cell carcinoma oral submucous fibrosis Oropharynx Physiological aspects protein biomarkers Proteins proteome discoverer Proteomics Scientific imaging secreted proteins serum Squamous cell carcinoma strong cation exchange chromatography United Kingdom > UK United States > US Germany proteome discoverer oral submucous fibrosis Body fluid proteomics OFFGEL electrophoresis secreted proteins strong cation exchange chromatography serum protein biomarkers
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Summary:	Background: Oral submucous fibrosis (OSMF) is a potentially malignant condition, which affects the oral cavity and the oropharynx. Despite the high prevalence rates of the disease and the morbidity and mortality related to the malignant transformation of 3%-19%, that is, OSMF into oral squamous cell carcinoma, there are fewer methods to identify the malignant transformation associated with OSMF. Dissecting the molecular aspects of these disorders will significantly contribute to improved prevention, early diagnosis, and clinical management. The complementary process involved in decreasing of the cellular components is called downregulation and the vice versa is known as upregulation. Materials and Methods: To predict the malignant transformation of OSMF, a study was conducted for quantitative proteomic profiling on the serum of histopathologically proven patients with OSMF to identify the candidate protein biomarkers. Among the differentially expressed proteins, only the downregulated proteins are included in the scope of this article. Results: During the study, 133 proteins were identified from the plasma of the case samples who histopathologically confirmed OSMF. These proteins were identified using mass spectrometric analysis. During the analysis, 14 proteins were differentially expressed. A fold change of more than 1.5 indicates upregulated proteins and less than 0.6 indicates downregulated proteins when compared with the control group. Conclusion: This study depicts the scope of the candidate protein biomarkers that can aid in definitive diagnosis of OSMF through a minimally invasive technique and help in the early detection and better treatment planning to reduce the morbidity of the disease in the future.
ISSN:	0972-1363 0975-1572
DOI:	10.4103/jiaomr.jiaomr_66_18