Search Results - "Kutsumura, Noriki"

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists by Nagahara, Takashi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Kuroda, Daisuke, Gouda, Hiroaki, Kumagai, Hidetoshi, Fujii, Hideaki, Yanagisawa, Masashi, Nagase, Hiroshi

“…Orexins are a family of neuropeptides that regulate sleep/wakefulness, acting on two G-protein-coupled receptors, orexin receptors 1 (OX1R) and 2 (OX2R)…”
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Design and Synthesis of Orexin 1 Receptor-Selective Agonists by Iio, Keita, Hashimoto, Kao, Nagumo, Yasuyuki, Amezawa, Mao, Hasegawa, Taisei, Yamamoto, Naoshi, Kutsumura, Noriki, Takeuchi, Katsuhiko, Ishikawa, Yukiko, Yamamoto, Hikari, Tokuda, Akihisa, Sato, Tetsu, Uchida, Yasuo, Inoue, Asuka, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi

“…Orexins are a family of neuropeptides that regulate various physiological events, such as sleep/wakefulness as well as emotional and feeding behavior, and that…”
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Total Synthesis of 3-epi-Juruenolide C by Kutsumura, Noriki, Inagaki, Mai, Kiriseko, Akito, Saito, Takao

“…In this study, the total synthesis of 3-epi-juruenolide C is achieved in 10 steps (longest linear sequence) starting from ethyl…”
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Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives by Saito, Takao, Sonoki, Yoshihiko, Otani, Takashi, Kutsumura, Noriki

“…A new approach towards the synthesis of indole derivatives via triflic acid-promoted cycloisomerization with rearrangement of 2-(alkyn-1-yl)phenyl…”
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Dibenzopyrrolo[1,2‑a][1,8]naphthyridines: Synthesis and Structural Modification of Fluorescent L‑Shaped Heteroarenes by Tateno, Kotaro, Ogawa, Rie, Sakamoto, Ryota, Tsuchiya, Mizuho, Kutsumura, Noriki, Otani, Takashi, Ono, Kosuke, Kawai, Hidetoshi, Saito, Takao

“…The L-shaped, π-extended pentacycle di­benzo­pyrrolo­[1,2-a]­[1,8]­naphthyridine and its derivatives were synthesized using two methods: fully intramolecular…”
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Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring by Iio, Keita, Saitoh, Tsuyoshi, Ohshita, Ryuichiro, Hino, Tsubasa, Amezawa, Mao, Takayama, Yoshiaki, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

“…[Display omitted] A novel series of 1-amino-tetralin derivatives were designed and synthesized based on the putative binding mode of the naphthalene-type…”
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Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton by Hino, Tsubasa, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

“…[Display omitted] A novel series of naphthalene derivatives were designed and synthesized based on the strategy focusing on the restriction of the flexible…”
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Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives by Katoh, Koki, Kutsumura, Noriki, Yamamoto, Naoshi, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

“…[Display omitted] The five-membered D-ring nalfurafine (d-nor-nalfurafine) derivatives with a 16-sulfonamide group were synthesized. Conversion of the…”
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Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands by Iio, Keita, Kutsumura, Noriki, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Tokuda, Akihisa, Hashimoto, Kao, Yamamoto, Naoshi, Kise, Ryoji, Inoue, Asuka, Mizoguchi, Hirokazu, Nagase, Hiroshi

“…[Display omitted] Mas-related G protein-coupled receptor X2 (MRGPRX2) mediates the itch response in neurons and is involved in atopic dermatitis…”
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Palladium-Catalyzed Highly Regio- and Stereoselective Synthesis of 4-Alkylidene-4H-3,1-benzoxazines from N-Acyl-o-alkynylanilines by Saito, Takao, Ogawa, Shohei, Takei, Naoya, Kutsumura, Noriki, Otani, Takashi

“…The highly regio- and stereoselective 6-exo-dig mode cyclization of N-acyl-o-alkynylanilines producing 4-alkylidene-3,1-benzoxazines occurred unpredictably by…”
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Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors by Katoh, Koki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Yanagisawa, Masashi, Nagase, Hiroshi

“…[Display omitted] To investigate the contribution of hydrogen bonding between the 14-hydroxy group and the 6-amide chain on the binding affinity of nalfurafine…”
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Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library by Saitoh, Tsuyoshi, Amezawa, Mao, Horiuchi, Jumpei, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Ohshita, Ryuichiro, Tokuda, Akihisa, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Hasegawa, Emi, Sakurai, Takeshi, Uchida, Yasuo, Sato, Tetsu, Gouda, Hiroaki, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

“…Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for…”
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Lewis Acid-Catalyzed or Base-Promoted Regioselective Cycloisomerization of N-Imidoyl-o-alkynylanilines for Synthesis of N-Imidoyl-(1 H)-indoles and 4-Alkylidene-3,4-dihydroquinazolines by Otani, Takashi, Jiang, Xue, Cho, Kinryo, Araki, Rino, Kutsumura, Noriki, Saito, Takao

“…Product selectivity control for the synthesis of imidoylindoles and 4‐alkylidenedihydroquinazolines from N‐imidoyl‐o‐alkynylanilines via silver…”
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The application of a specific morphinan template to the synthesis of galanthamine by Yamamoto, Naoshi, Okada, Takahiro, Harada, Yukimasa, Kutsumura, Noriki, Imaide, Satomi, Saitoh, Tsuyoshi, Fujii, Hideaki, Nagase, Hiroshi

“…(–)-Galanthamine (4) was synthesized from naltrexone (1) in 18 steps with 3% total yield by overcoming many specific side reactions derived from the…”
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Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group by Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Yanagisawa, Masashi, Nagase, Hiroshi

“…[Display omitted] The morphinan-type orexin 1 receptor (OX1R) antagonists such as YNT-707 (2) and YNT-1310 (3) show potent and extremely high selective…”
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Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity by Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

“…[Display omitted] The orexin 1 receptor (OX1R) antagonists carrying a morphinan skeleton such as YNT-707 (2) and YNT-1310 (3) showed potent and extremely high…”
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Novel One-Pot Method for Chemoselective Bromination and Sequential Sonogashira Coupling by Kutsumura, Noriki, Niwa, Kentaro, Saito, Takao

“…An efficient one-pot method for bromination−elimination of allyl alcohol derivatives and sequential Sonogashira coupling has been developed. A highlight of the…”
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ZnCl2-Promoted Intramolecular Hetero-Diels–Alder Reaction of o-Alkynylphenylcarbodiimides for Synthesis of Dihydrodibenzo[b,g][1,8]naphthyridines by Kutsumura, Noriki, Koyama, Yasuaki, Tateno, Kotaro, Yamamoto, Naoshi, Nagase, Hiroshi, Saito, Takao

“…The ZnCl2-promoted intramolecular hetero-Diels–Alder reaction of N-(ortho-propargylphenyl)-N′-arylcarbodiimides, in which the aryl-N=C moiety functioned as a…”
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Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity by Ohrui, Sayaka, Yamamoto, Naoshi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Yanagisawa, Masashi, Nagase, Hiroshi

“…[Display omitted] The 14-dehydration- and 14-H derivatives of the orexin 1 receptor (OX1R) antagonist YNT-707 (2) were synthesized. The obtained derivatives…”
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Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring by Yamamoto, Naoshi, Ohrui, Sayaka, Okada, Takahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Yanagisawa, Masashi, Nagase, Hiroshi

“…[Display omitted] Morphinan derivatives lacking the 4,5-epoxy ring were synthesized to examine the participation of the 14-OH group, the 3-OMe group, and the…”
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