Search Results - "Kutok, J"

The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL by Balakrishnan, K, Peluso, M, Fu, M, Rosin, N Y, Burger, J A, Wierda, W G, Keating, M J, Faia, K, O'Brien, S, Kutok, J L, Gandhi, V

“…The functional relevance of the B-cell receptor (BCR) and the evolution of protein kinases as therapeutic targets have recently shifted the paradigm for…”
Get full text

Spectrum of Epstein-Barr virus-associated diseases by Kutok, J L, Wang, F

“…The association between Epstein-Barr virus (EBV) and a large number of benign and malignant diseases is unique among DNA viruses. Within infected tissues,…”
Get full text

BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells by French, C A, Ramirez, C L, Kolmakova, J, Hickman, T T, Cameron, M J, Thyne, M E, Kutok, J L, Toretsky, J A, Tadavarthy, A K, Kees, U R, Fletcher, J A, Aster, J C

“…An unusual group of carcinomas, here termed nuclear protein in testis (NUT) midline carcinomas (NMC), are characterized by translocations that involve NUT , a…”
Get full text

Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia by Krajinovic, M, Elbared, J, Drouin, S, Bertout, L, Rezgui, A, Ansari, M, Raboisson, M-J, Lipshultz, S E, Silverman, L B, Sallan, S E, Neuberg, D S, Kutok, J L, Laverdière, C, Sinnett, D, Andelfinger, G

“…Anthracyclines are efficient chemotherapy agents. However, their use is limited by anthracycline-induced cardiotoxicity (CT). We investigated the influence of…”
Get full text

Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199) by Patel, V M, Balakrishnan, K, Douglas, M, Tibbitts, T, Xu, E Y, Kutok, J L, Ayers, M, Sarkar, A, Guerrieri, R, Wierda, W G, O'Brien, S, Jain, N, Stern, H M, Gandhi, V

“…Duvelisib, an oral dual inhibitor of PI3K-δ and PI3K-γ, is in phase III trials for the treatment of chronic lymphocytic leukemia (CLL) and indolent…”
Get full text

Cisplatin benefit is predicted by immunohistochemical analysis of DNA repair proteins in squamous cell carcinoma but not adenocarcinoma: theranostic modeling by NSCLC constituent histological subclasses by Pierceall, W.E., Olaussen, K.A., Rousseau, V., Brambilla, E., Sprott, K.M., Andre, F., Pignon, J.-P., Le Chevalier, T., Pirker, R., Jiang, C., Filipits, M., Chen, Y., Kutok, J.L., Weaver, D.T., Ward, B.E., Soria, J.-C.

“…Most non-small-cell lung cancer (NSCLC) patients receive cisplatin-based chemotherapy though clinical response is restricted to a subset of patients. DNA…”
Get full text

A Tyrosine Kinase Created by Fusion of the PDGFRA and FIP1L1 Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome by Cools, Jan, DeAngelo, Daniel J, Gotlib, Jason, Stover, Elizabeth H, Legare, Robert D, Cortes, Jorges, Kutok, Jeffrey, Clark, Jennifer, Galinsky, Ilene, Griffin, James D, Cross, Nicholas C.P, Tefferi, Ayalew, Malone, James, Alam, Rafeul, Schrier, Stanley L, Schmid, Janet, Rose, Michal, Vandenberghe, Peter, Verhoef, Gregor, Boogaerts, Marc, Wlodarska, Iwona, Kantarjian, Hagop, Marynen, Peter, Coutre, Steven E, Stone, Richard, Gilliland, D. Gary

“…A fusion between the PDGFRA and FIP1L1 genes was found in some cases of the hypereosinophilic syndrome, a fatal disorder in which eosinophils invade and…”
Get full text

Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling by Tournilhac, O., Santos, D. D., Xu, L., Kutok, J., Tai, Y.-T., Le Gouill, S., Catley, L., Hunter, Z., Branagan, A. R., Boyce, J. A., Munshi, N., Anderson, K. C., Treon, S. P.

“…Bone marrow (BM) mast cells (MC) are commonly found in association with lymphoplasmacytic cells (LPC) in patients with Waldenström's macroglobulinemia (WM)…”
Get full text

Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia by Krajinovic, M, Elbared, J, Drouin, S, Bertout, L, Rezgui, A, Ansari, M, Raboisson, M-J, Lipshultz, S E, Silverman, L B, Sallan, S E, Neuberg, D S, Kutok, J L, Laverdière, C, Sinnett, D, Andelfinger, G

Get full text

B cell receptor signal strength determines B cell fate by Casola, Stefano, Rajewsky, Klaus, Otipoby, Kevin L, Alimzhanov, Marat, Humme, Sibille, Uyttersprot, Nathalie, Kutok, Jeffery L, Carroll, Michael C

“…B cell receptor (BCR)-mediated antigen recognition is thought to regulate B cell differentiation. BCR signal strength may also influence B cell fate decisions…”
Get full text

BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma by Patton, E.Elizabeth, Widlund, Hans R., Kutok, Jeffery L., Kopani, Kamden R., Amatruda, James F., Murphey, Ryan D., Berghmans, Stephane, Mayhall, Elizabeth A., Traver, David, Fletcher, Christopher D.M., Aster, Jon C., Granter, Scott R., Look, A.Thomas, Lee, Charles, Fisher, David E., Zon, Leonard I.

“…Melanoma is the most lethal form of skin cancer, and the incidence and mortality rates are rapidly rising. Epidemiologically, high numbers of nevi (moles) are…”
Get full text

401 Impact of Saridegib (IPI-926) On Smoothened Ciliary Localization and Hedgehog Pathway Activity by Peluso, M, Faia, K, Campbell, V, DiNitto, J, Harari, J, Proctor, J, Pink, M, McGovern, K, Kutok, J, Read, M

Get full text

Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation by Frantsve, Julie, Schwaller, Juerg, Sternberg, David W., Kutok, Jeffery, Gilliland, D. Gary

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation by Araki, Toshiyuki, Mohi, M Golam, Ismat, Fraz A, Bronson, Roderick T, Williams, Ifor R, Kutok, Jeffery L, Yang, Wentian, Pao, Lily I, Gilliland, D Gary, Epstein, Jonathan A, Neel, Benjamin G

“…Noonan syndrome is a common human autosomal dominant birth defect, characterized by short stature, facial abnormalities, heart defects and possibly increased…”
Get full text

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning by Shipp, Margaret A, Golub, Todd R, Ross, Ken N, Tamayo, Pablo, Weng, Andrew P, Kutok, Jeffery L, Aguiar, Ricardo C.T, Gaasenbeek, Michelle, Angelo, Michael, Reich, Michael, Pinkus, Geraldine S, Ray, Tane S, Koval, Margaret A, Last, Kim W, Norton, Andrew, Lister, T. Andrew, Mesirov, Jill, Neuberg, Donna S, Lander, Eric S, Aster, Jon C

“…Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is curable in less than 50% of patients. Prognostic models based on…”
Get full text

Myc-Induced T Cell Leukemia in Transgenic Zebrafish by Langenau, David M., Traver, David, Ferrando, Adolfo A., Kutok, Jeffery L., Aster, Jon C., Kanki, John P., Lin, Shuo, Prochownik, Ed, Trede, Nikolaus S., Zon, Leonard I., Look, A. Thomas

“…The zebrafish is an attractive model organism for studying cancer development because of its genetic accessibility. Here we describe the induction of clonally…”
Get full text

In vivo Tracking of T Cell Development, Ablation, and Engraftment in Transgenic Zebrafish by Langenau, David M., Ferrando, Adolfo A., Traver, David, Kutok, Jeffery L., Hezel, John-Paul D., Kanki, John P., Zon, Leonard I., Look, A. Thomas, Trede, Nikolaus S., Alt, Frederick W.

“…Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase (lck) promoter were used to analyze critical aspects of the immune…”
Get full text

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination by Manis, John P, Morales, Julio C, Xia, Zhenfang, Kutok, Jeffery L, Alt, Frederick W, Carpenter, Phillip B

“…The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine…”
Get full text

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 ( PTPN11) mutations by Mohi, M. Golam, Williams, Ifor R., Dearolf, Charles R., Chan, Gordon, Kutok, Jeffery L., Cohen, Sarah, Morgan, Kelly, Boulton, Christina, Shigematsu, Hirokazu, Keilhack, Heike, Akashi, Koichi, Gilliland, D. Gary, Neel, Benjamin G.

“…The SH2-containing tyrosine phosphatase Shp2 ( PTPN11) is required for growth factor and cytokine signaling. Germline Shp2 mutations cause Noonan Syndrome…”
Get full text

Bad-Deficient Mice Develop Diffuse Large B Cell Lymphoma by Ranger, Ann M., Zha, Jiping, Harada, Hisashi, Datta, Sandeep Robert, Danial, Nika N., Gilmore, Andrew P., Kutok, Jeffery L., Le Beau, Michelle M., Greenberg, Michael E., Korsmeyer, Stanley J.

“…The proapoptotic activity of the "BH3-only" molecule BAD can be differentially regulated by survival factor signaling. Bad-deficient mice lacking both BAD long…”
Get full text