Search Results - "Kutil, Zsofia"

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity by Zessin, Matthes, Kutil, Zsófia, Meleshin, Marat, Nováková, Zora, Ghazy, Ehab, Kalbas, Diana, Marek, Martin, Romier, Christophe, Sippl, Wolfgang, Bařinka, Cyril, Schutkowski, Mike

“…We developed a one-step direct assay for the determination of histone deacylase (HDAC) activity by substituting the carbonyl oxygen of the acyl moiety with…”
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Structure-based molecular modeling in SAR analysis and lead optimization by Temml, Veronika, Kutil, Zsofia

“…[Display omitted] In silico methods like molecular docking and pharmacophore modeling are established strategies in lead identification. Their successful…”
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A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging by Zhang, Jingming, Rakhimbekova, Anastasia, Duan, Xiaojiang, Yin, Qingqing, Foss, Catherine A., Fan, Yan, Xu, Yangyang, Li, Xuesong, Cai, Xuekang, Kutil, Zsofia, Wang, Pengyuan, Yang, Zhi, Zhang, Ning, Pomper, Martin G., Wang, Yiguang, Bařinka, Cyril, Yang, Xing

“…Surgery is an efficient way to treat localized prostate cancer (PCa), however, it is challenging to demarcate rapidly and accurately the tumor boundary…”
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Predicting Effects of Site-Directed Mutagenesis on Enzyme Kinetics by QM/MM and QM Calculations: A Case of Glutamate Carboxypeptidase II by Bím, Daniel, Navrátil, Michal, Gutten, Ondrej, Konvalinka, Jan, Kutil, Zsófia, Culka, Martin, Navrátil, Václav, Alexandrova, Anastassia N, Bařinka, Cyril, Rulíšek, Lubomír

“…Quantum and molecular mechanics (QM/MM) and QM-only (cluster model) modeling techniques represent the two workhorses in mechanistic understanding of enzyme…”
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Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome by Kozikowski, Alan P, Shen, Sida, Pardo, Marta, Tavares, Maurício T, Szarics, Dora, Benoy, Veronick, Zimprich, Chad A, Kutil, Zsófia, Zhang, Guiping, Bařinka, Cyril, Robers, Matthew B, Van Den Bosch, Ludo, Eubanks, James H, Jope, Richard S

“…Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there are no effective treatments or cures. Herein, we report on a…”
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Characterization of the class IIa histone deacetylases substrate specificity by Kutil, Zsofia, Meleshin, Marat, Baranova, Petra, Havlinova, Barbora, Schutkowski, Mike, Barinka, Cyril

“…Class IIa histone deacetylases (HDACs) play critical roles in vertebrate development and physiology, yet direct evidence of their intrinsic deacetylase…”
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Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors by Kutil, Zsófia, Mikešová, Jana, Zessin, Matthes, Meleshin, Marat, Nováková, Zora, Alquicer, Glenda, Kozikowski, Alan, Sippl, Wolfgang, Bařinka, Cyril, Schutkowski, Mike

“…Histone deacetylase 11 (HDAC11) preferentially removes fatty acid residues from lysine side chains in a peptide or protein environment. Here, we report the…”
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The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries by Kutil, Zsofia, Skultetyova, Lubica, Rauh, David, Meleshin, Marat, Snajdr, Ivan, Novakova, Zora, Mikesova, Jana, Pavlicek, Jiri, Hadzima, Martin, Baranova, Petra, Havlinova, Barbora, Majer, Pavel, Schutkowski, Mike, Barinka, Cyril

“…ABSTRACT Histone deacetylase 6 (HDAC6) is a multidomain cytosolic hydrolase acting mostly on nonhistone protein substrates. Investigations of the substrate…”
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Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells by Ptacek, Jakub, Snajdr, Ivan, Schimer, Jiri, Kutil, Zsofia, Mikesova, Jana, Baranova, Petra, Havlinova, Barbora, Tueckmantel, Werner, Majer, Pavel, Kozikowski, Alan, Barinka, Cyril

“…Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family of enzymes due to its complex domain organization and cytosolic localization. Experimental…”
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Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene by Novakova, Zora, Milosevic, Mirko, Kutil, Zsofia, Ondrakova, Marketa, Havlinova, Barbora, Kasparek, Petr, Sandoval-Acuña, Cristian, Korandova, Zuzana, Truksa, Jaroslav, Vrbacky, Marek, Rohlena, Jakub, Barinka, Cyril

“…In humans, disruptions in the heme biosynthetic pathway are associated with various types of porphyrias, including variegate porphyria that results from the…”
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Characterization of glutamate carboxypeptidase 2 orthologs in trematodes by Jedlickova, Lucie, Peterkova, Kristyna, Boateng, Enoch Mensah, Ulrychova, Lenka, Vacek, Vojtech, Kutil, Zsofia, Jiang, Zhenze, Novakova, Zora, Snajdr, Ivan, Kim, Juan, O'Donoghue, Anthony J, Barinka, Cyril, Dvorak, Jan

“…Glutamate carboxypeptidase 2 (GCP2) belongs to the M28B metalloprotease subfamily encompassing a variety of zinc-dependent exopeptidases that can be found in…”
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Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity by Landa, Premysl, Schuster, Daniela, Dvorakova, Marcela, Pribylova, Marie, Maghradze, David, Temml, Veronika, Kutil, Zsofia, Vanek, Tomas

“…Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the…”
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Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea by Zia-ul-Haq, M, Khan, Barkat Ali, Landa, Premysl, Kutil, Zsófia, Ahmed, Sagheer, Qayum, Mughal, Ahmad, Shakeel

“…Inflammation is the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body. This study was aimed to…”
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Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model by Shen, Sida, Picci, Cristina, Ustinova, Kseniya, Benoy, Veronick, Kutil, Zsófia, Zhang, Guiping, Tavares, Maurício T, Pavlíček, Jiří, Zimprich, Chad A, Robers, Matthew B, Van Den Bosch, Ludo, Bařinka, Cyril, Langley, Brett, Kozikowski, Alan P

“…Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6…”
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Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis by Hanáková, Zuzana, Hošek, Jan, Kutil, Zsófia, Temml, Veronika, Landa, Přemysl, Vaněk, Tomáš, Schuster, Daniela, Dall’Acqua, Stefano, Cvačka, Josef, Polanský, Ondřej, Šmejkal, Karel

“…Geranyl flavones have been studied as compounds that potentially can be developed as anti-inflammatory agents. A series of natural geranylated flavanones was…”
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Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6) by Motlová, Lucia, Šnajdr, Ivan, Kutil, Zsófia, Andris, Erik, Ptáček, Jakub, Novotná, Adéla, Nováková, Zora, Havlínová, Barbora, Tueckmantel, Werner, Dráberová, Helena, Majer, Pavel, Schutkowski, Mike, Kozikowski, Alan, Rulíšek, Lubomír, Bařinka, Cyril

“…Histone deacetylase (HDAC) inhibitors used in the clinic typically contain a hydroxamate zinc-binding group (ZBG). However, more recent work has shown that the…”
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Tunnel vision in the drinking water research field – Time for non-targeted analysis implementation? by Kutil, Zsofia, Novotna, Katerina, Cermakova, Lenka, Pivokonsky, Martin

“…A plethora of compounds can reach our drinking water and possibly affect human health. Still, mostly notorious pollutants like pesticides and disinfection…”
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Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models by Tavares, Maurício T, Shen, Sida, Knox, Tessa, Hadley, Melissa, Kutil, Zsófia, Bařinka, Cyril, Villagra, Alejandro, Kozikowski, Alan P

“…Only a handful of therapies offer significant improvement in the overall survival in cases of melanoma, a cancer whose incidence has continued to rise in the…”
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Histone Deacetylase 11 Is a Fatty-Acid Deacylase by Kutil, Zsofia, Novakova, Zora, Meleshin, Marat, Mikesova, Jana, Schutkowski, Mike, Barinka, Cyril

“…Histone deacetylase 11 (HDAC11) is a sole member of the class IV HDAC subfamily with negligible intrinsic deacetylation activity. Here, we report in vitro…”
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Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro by Hošek, Jan, Bartos, Milan, Chudík, Stanislav, Dall’Acqua, Stefano, Innocenti, Gabbriella, Kartal, Murat, Kokoška, Ladislav, Kollár, Peter, Kutil, Zsófia, Landa, Přemysl, Marek, Radek, Závalová, Veronika, Žemlička, Milan, Šmejkal, Karel

“…Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed…”
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