Search Results - "Kute, Timothy"

Yin Yang 1 Plays an Essential Role in Breast Cancer and Negatively Regulates p27 by Wan, Meimei, Huang, Weiwei, Kute, Timothy E, Miller, Lance D, Zhang, Qiang, Hatcher, Heather, Wang, Jingxuan, Stovall, Daniel B, Russell, Gregory B, Cao, Paul D, Deng, Zhiyong, Wang, Wei, Zhang, Qingyuan, Lei, Ming, Torti, Suzy V, Akman, Steven A, Sui, Guangchao

“…Yin Yang 1 (YY1) is highly expressed in various types of cancers and regulates tumorigenesis through multiple pathways. In the present study, we evaluated YY1…”
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Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation by Zhang, Qiang, Wan, Meimei, Shi, Jinming, Horita, David A, Miller, Lance D, Kute, Timothy E, Kridel, Steven J, Kulik, George, Sui, Guangchao

“…Yin Yang 1 (YY1) regulates both gene expression and protein modifications, and has shown a proliferative role in cancers. In this study, we demonstrate that…”
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Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux by Morrow, Charles S, Peklak-Scott, Christina, Bishwokarma, Bimjhana, Kute, Timothy E, Smitherman, Pamela K, Townsend, Alan J

“…Based upon several previous reports, no consistent relationship between multidrug resistance protein 1 (MRP1, ABCC1) expression and cellular sensitivity to…”
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Breast tumor cells isolated from in vitro resistance to trastuzumab remain sensitive to trastuzumab anti-tumor effects in vivo and to ADCC killing by Kute, Timothy E, Savage, Lori, Stehle, John R. Jr, Kim-Shapiro, Jung W, Blanks, Michael J, Wood, James, Vaughn, James P

“…An understanding of model systems of trastuzumab (Herceptin) resistance is of great importance since the humanized monoclonal antibody is now used as first…”
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Inhibition of DNA Synthesis by a Platinum–Acridine Hybrid Agent Leads to Potent Cell Kill in Nonsmall Cell Lung Cancer by Smyre, Christopher L, Saluta, Gilda, Kute, Timothy E, Kucera, Gregory L, Bierbach, Ulrich

“…The platinum–acridine anticancer agent [PtCl(en)(LH)](NO3)2 (1) [en = ethane-1,2-diamine, LH = N-(2-(acridin-9-ylamino)ethyl)-N-methylpropionimidamide,…”
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Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells by Kute, Timothy, Stehle, Jr, John R., Ornelles, David, Walker, Natalie, Delbono, Osvaldo, Vaughn, James P.

“…Use of the antibody trastuzumab to kill HER2+ breast cancer cells is an attractive therapy because of its specificity and minimal adverse effects. However, a…”
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SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer by Clausen, Kathryn A., Blish, Kimberly R., Birse, Charles E., Triplette, Matthew A., Kute, Timothy E., Russell, Gregory B., D’Agostino, Ralph B., Miller, Lance D., Torti, Frank M., Torti, Suzy V.

“…Sclerostin domain containing 1 (SOSTDC1) protein regulates processes from development to cancer by modulating activity of bone morphogenetic protein (BMP) and…”
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Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity by Smitherman, Pamela K, Townsend, Alan J, Kute, Timothy E, Morrow, Charles S

“…Our previous studies have shown that the glutathione S-transferases (GSTs) can operate in synergy with the efflux transporter multidrug resistance protein 1…”
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Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation by Turner, JoLyn, Koumenis, Constantinos, Kute, Timothy E., Planalp, Roy P., Brechbiel, Martin W., Beardsley, Dillon, Cody, Brooke, Brown, Kevin D., Torti, Frank M., Torti, Suzy V.

“…Iron is critical for cell growth and proliferation. Iron chelators are being explored for a number of clinical applications, including the treatment of…”
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erbB-2, p53, and Efficacy of Adjuvant Therapy in Lymph Node-Positive Breast Cancer by Thor, Ann D., Berry, Donald A., Budman, Daniel R., Muss, Hyman B., Kute, Timothy, Henderson, I. Craig, Barcos, Maurice, Cirrincione, Constance, Edgerton, Susan, Allred, Craig, Norton, Larry, Liu, Edison T.

“…Background: We have previously reported that high expression of the erbB-2 gene (also known as HER-2/neu and ERBB2) in breast cancer is associated with patient…”
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Development of Herceptin resistance in breast cancer cells by Kute, Timothy, Lack, Christopher M., Willingham, Mark, Bishwokama, Bimjhana, Williams, Holly, Barrett, Kathy, Mitchell, Tanita, Vaughn, James P.

“…Background Herceptin, a humanized antibody to HER‐2, is now utilized in the clinic for metastatic breast cancer treatment. The response rate for HER‐2+…”
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5-Oxo-ETE analogs and the proliferation of cancer cells by O'Flaherty, Joseph T., Rogers, LeAnn C., Paumi, Christian M., Hantgan, Roy R., Thomas, Lance R., Clay, Carl E., High, Kevin, Chen, Yong Q., Willingham, Mark C., Smitherman, Pamela K., Kute, Timothy E., Rao, Anuradha, Cramer, Scott D., Morrow, Charles S.

“…MDA-MB-231, MCF7, and SKOV3 cancer cells, but not HEK-293 cells, expressed mRNA for the leukocyte G protein-coupled 5-oxo-eicosatetraenoate (ETE) OXE receptor…”
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Genistein and vitamin D synergistically inhibit human prostatic epithelial cell growth by Rao, Anuradha, Woodruff, Ralph D, Wade, Wendy N, Kute, Timothy E, Cramer, Scott D

“…We performed studies to test synergism between the growth inhibitory effects of genistein and vitamin D compounds on prostatic epithelial cells. Isobolographic…”
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Measurement of PTEN expression using tissue microarrays to determine a race-specific prognostic marker in breast cancer by Winter, Jerald Luke, Stackhouse, Bodiford L, Russell, Gregory B, Kute, Timothy E

“…African American women with breast cancer have worse prognoses than non-African Americans and might benefit with a race-specific prognostic marker such as PTEN…”
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Expression of Microtubule-Associated Protein 2 in Benign and Malignant Melanocytes : Implications for Differentiation and Progression of Cutaneous Melanoma by Fang, Dong, Hallman, James, Sangha, Namrata, Kute, Timothy E, Hammarback, James A, White, Wain L, Setaluri, Vijayasaradhi

“…Cutaneous melanocytic neoplasms are known to acquire variable characteristics of neural crest differentiation. Melanocytic nevus cells in the dermis and…”
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Intrabody-based strategies for inhibition of vascular endothelial growth factor receptor-2: effects on apoptosis, cell growth, and angiogenesis by Wheeler, Yurong Yang, Kute, Timothy E, Willingham, Mark C, Chen, Si-Yi, Sane, David C

“…VEGF, an endothelial-specific mitogen, is an important tumor angiogenesis growth factor. The major receptor for VEGF on endothelial cells is KDR. We…”
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DNA strand breaks and cell cycle perturbation in Herceptin treated breast cancer cell lines by MAYFIELD, Scott, VAUGHN, James P, KUTE, Timothy E

“…Herceptin is a humanized antibody that binds to the product of the HER-2 oncogene. Clinical studies have indicated that treatment with Herceptin may slow…”
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Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells by Clay, Carl E., Namen, Andrew M., Atsumi, Gen-ichi, Willingham, Mark C., High, Kevin P., Kute, Timothy E., Trimboli, Anthony J., Fonteh, Alfred N., Dawson, Paul A., Chilton, Floyd H.

“…This study was undertaken to investigate the influence of the peroxisome proliferator-activated receptor γ (PPARγ) agonists on the proliferation, apoptosis and…”
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Polyploid Formation via Chromosome Duplication Induced by CTP:Phosphocholine Cytidylyltransferase Deficiency and Bcl-2 Overexpression: Identification of Two Novel Endogenous Factors by Shen, You-Jun, DeLong, Cynthia J, Terce, Francois, Kute, Timothy, Willingham, Mark C, Pettenati, Mark J, Cui, Zheng

“…Polyploidy is a profound phenotype found in tumors and its mechanism is unknown. We report here that when B-cell lymphoma gene-2 (Bcl-2) was overexpressed in a…”
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Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays by KUTE T. E, ZHI-MING SHAO, SUGG, N. K, LONG, R. T, RUSSELL, G. B, CASE, L. D

“…This is a retrospective study on 162 node-negative patients, with both biochemical and clinical factors being measured for determination of prognostic markers…”
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