Search Results - "Kuszak, Jer R."

Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome by Moncaster, Juliet A, Pineda, Roberto, Moir, Robert D, Lu, Suqian, Burton, Mark A, Ghosh, Joy G, Ericsson, Maria, Soscia, Stephanie J, Mocofanescu, Anca, Folkerth, Rebecca D, Robb, Richard M, Kuszak, Jer R, Clark, John I, Tanzi, Rudolph E, Hunter, David G, Goldstein, Lee E

“…Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication…”
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Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice by Lassen, Natalie, Bateman, J Bronwyn, Estey, Tia, Kuszak, Jer R, Nees, David W, Piatigorsky, Joram, Duester, Gregg, Day, Brian J, Huang, Jie, Hines, Lisa M, Vasiliou, Vasilis

“…ALDH3A1 (aldehyde dehydrogenase 3A1) is abundant in the mouse cornea but undetectable in the lens, and ALDH1A1 is present at lower (catalytic) levels in the…”
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Development of lens sutures by Kuszak, Jer R, Zoltoski, Rebecca K, Tiedemann, Clifford E

“…Cylindrical map projections (CMPs) have been used for centuries as an effective means of plotting the features of a 3D spheroidal surfaces (e.g. the earth) on…”
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Age-related cataracts in α3Cx46-knockout mice are dependent on a calpain 3 isoform by YAJUN TANG, XIANGYANG LIU, ZOLTOSKI, Rebecca K, NOVAK, Layne A, HERRERA, R. Antonio, RICHARD, Isabelle, KUSZAK, Jer R, KUMAR, Nalin M

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Analysis of nuclear fiber cell compaction in transparent and cataractous diabetic human lenses by scanning electron microscopy by Freel, Christopher D, al-Ghoul, Kristin J, Kuszak, Jer R, Costello, M Joseph

“…Compaction of human ocular lens fiber cells as a function of both aging and cataractogenesis has been demonstrated previously using scanning electron…”
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Computer modeling of secondary fiber development and growth: I. Nonprimate lenses by Kuszak, Jer R, Mazurkiewicz, Mike, Zoltoski, Rebecca

“…The purpose of this study was to use qualitative and quantitative structural data from nonprimate lenses with branched (Y and line) sutures to generate…”
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The Effect of Photochemical Stress Upon the Lenses of Normal and Glutathione Peroxidase-1 Knockout Mice by SPECTOR, ABRAHAM, KUSZAK, JER R, MA, WANCHAO, WANG, REN-RONG, HO, YE-SHIH, YANG, YINQING

“…This communication investigates the effect of oxidative stress upon the lenses of young normal and glutathione peroxidase-1 (GSHPx-1) Knockout mice. Both…”
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Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract by Sandilands, Aileen, Prescott, Alan R, Wegener, Alfred, Zoltoski, Rebecca K, Hutcheson, Aileen M, Masaki, Shigeo, Kuszak, Jer R, Quinlan, Roy A

“…In this report, the phenotype associated with the first targeted knockout of the lens specific intermediate filament gene CP49 is described. Several surprising…”
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Structural Evidence of Human Nuclear Fiber Compaction as a Function of Ageing and Cataractogenesis by Al-Ghoul, Kristin J., Nordgren, Rachel K., Kuszak, Adam J., Freel, Christopher D., Costello, M.Joseph, Kuszak, Jer R.

“…This study was conducted to quantify structural change associated with human nuclear fiber compaction as a function of ageing and nuclear cataract formation…”
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Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome by Moncaster, Juliet A, Pineda, Roberto, Moir, Robert D, Lu, Suqian, Burton, Mark A, Ghosh, Joy G, Ericsson, Maria, Soscia, Stephanie J, Mocofanescu, Anca, Folkerth, Rebecca D, Robb, Richard, Kuszak, Jer R, Clark, John I, Tanzi, Rudolph E, Hunter, David G, Goldstein, Lee E

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Multiple and Additive Functions of ALDH3A1 and ALDH1A1 by Lassen, Natalie, Bateman, J. Bronwyn, Estey, Tia, Kuszak, Jer R., Nees, David W., Piatigorsky, Joram, Duester, Gregg, Day, Brian J., Huang, Jie, Hines, Lisa M., Vasiliou, Vasilis

“…ALDH3A1 (aldehyde dehydrogenase 3A1) is abundant in the mouse cornea but undetectable in the lens, and ALDH1A1 is present at lower (catalytic) levels in the…”
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The effect of aging on glutathione peroxidase-1 knockout mice-resistance of the lens to oxidative stress by SPECTOR, Abraham, KUSZAK, Jer R, MA, Wanchao, WANG, Ren-Rong

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Morphology and organization of posterior fiber ends during migration by Al-Ghoul, Kristin J, Kuszak, Jer R, Lu, Jeffrey Y, Owens, Michael J

“…To characterize structural parameters of the basal membrane complex (BMC) and to determine the arrangement and organization of posterior fiber ends during…”
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Lens structure in MIP‐deficient mice by Al‐Ghoul, Kristin J., Kirk, Tyler, Kuszak, Adam J., Zoltoski, Rebecca K., Shiels, Alan, Kuszak, Jer R.

“…In this study we used correlative light, scanning, and transmission (freeze‐etch) electron microscopy to characterize lens structure in normal mice and compare…”
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A brief photochemically induced oxidative insult causes irreversible lens damage and cataract I. Transparency and epithelial cell layer by Spector, Abraham, Wang, Guo-Ming, Wang, Ren-Rong, Li, Wan-Cheng, Kuszak, Jer R.

“…Short-term photochemical insult of cultured rat lenses caused by the generation of H 2O 2, O 2 .− and OH . was found to lead to rapid irreversible damage to…”
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The Effect of Aging on Glutathione Peroxidase-I Knockout Mice—Resistance of the Lens to Oxidative Stress by Spector, Abraham, Kuszak, Jer R, Ma, Wanchao, Wang, Ren-Rong

“…Populations of control, C, and glutathione peroxidase-1 (GPx-1) knockout mice, K, were studied over a period of 2 years. No significant difference was observed…”
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Alzheimer's Disease Amyloid-[beta] Links Lens and Brain Pathology in Down Syndrome by Moncaster, Juliet A, Pineda, Roberto, Moir, Robert D, Lu, Suqian, Burton, Mark A, Ghosh, Joy G, Ericsson, Maria, Soscia, Stephanie J, Mocofanescu, Anca, Folkerth, Rebecca D, Robb, Richard M, Kuszak, Jer R, Clark, John I, Tanzi, Rudolph E, Hunter, David G, Goldstein, Lee E

“…Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication…”
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Multiple and Additive Functions of ALDH3A1 and ALDH1A1: CATARACT PHENOTYPE AND OCULAR OXIDATIVE DAMAGE IN Aldh3a1(−/−)/Aldh1a1(−/−) KNOCK-OUT MICES by Lassen, Natalie, Bateman, J. Bronwyn, Estey, Tia, Kuszak, Jer R., Nees, David W., Piatigorsky, Joram, Duester, Gregg, Day, Brian J., Huang, Jie, Hines, Lisa M., Vasiliou, Vasilis

“…ALDH3A1 (aldehyde dehydrogenase 3A1) is abundant in the mouse cornea but undetectable in the lens, and ALDH1A1 is present at lower (catalytic) levels in the…”
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Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform by Tang, Yajun, Liu, Xiangyang, Zoltoski, Rebecca K, Novak, Layne A, Herrera, R Antonio, Richard, Isabelle, Kuszak, Jer R, Kumar, Nalin M

“…Previous studies have demonstrated that in 129alpha3Cx46-/- mice, age-related nuclear cataract is formed. In the present study, a more in vivo-relevant model…”
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P4‐010: Alzheimer's Disease Amyloid‐β Links Lens and Brain Pathology in Down Syndrome by Moncaster, Juliet A., Pineda, Roberto, Moir, Robert D., Lu, Suqian, Burton, Mark A., Ghosh, Joy G., Ericsson, Maria, Soscia, Stephanie J., Mocofanescu, Anca, Folkerth, Rebecca D., Robb, Richard, Kuszak, Jer R., Clark, John I., Tanzi, Rudolph E., Hunter, David G., Goldstein, Lee E.

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