The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats

The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats

Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites. Hepatogomax enteral formula was developed, which contains brain-chain amino acids (BC...

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Bibliographic Details
Published in:Journal of nutrition and metabolism Vol. 2023; pp. 1 - 9
Main Authors: Purnomo, Hery D., Kusuma, Refani A., Sianturi, Elfrida, Haroen, Ryan F., Solichin, Muchamad R., Nissa, Choirun, Pramono, Adriyan, Mahati, Endang, Noer, Etika R.
Format: Journal Article
Language:English
Published: New York Hindawi 14-09-2023
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Amino acids
Cytokines
Disease susceptibility
Fatty acids
Fatty liver
Fibrosis
Food science
Histochemistry
Histopathology
Immune response
Inflammation
Interleukin 6
Liver cirrhosis
Liver diseases
Metabolism
Metabolites
Microbiota
Nutrition
Proteins
Steatosis
Testing laboratories
Thioacetamide
Triglycerides
Tumor necrosis factor
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Indonesia
Yogyakarta Indonesia
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Summary:Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites. Hepatogomax enteral formula was developed, which contains brain-chain amino acids (BCAAs) and middle-chain triglycerides (MCTs), which could repair liver tissue damage, improve the inflammatory status, and modulate SCFA in liver damage. The study aimed to determine the effect of hepatogomax on liver tissue repair, inflammation (TNF-α and IL-6), and SCFA levels in thioacetamide (TAA)-induced rats. The induction of TAA causes liver steatosis, increasing TNF-α and IL-6, and decreasing SCFA levels. Hepatogomax at a dose of 14.6 g/200 gBW significantly reduces TNF-α and IL-6 levels and increases SCFA levels (p < 0.05). The number of steatosis between groups P2 and P3 was lower as compared to a group of negative control [K2] (p < 0.05). Hepatogomax, in a dose-dependent manner, may repair liver tissue and improve inflammatory response and SCFA levels in TAA-induced rats.
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Academic Editor: Karen L. Sweazea
ISSN:2090-0724
2090-0732
DOI:10.1155/2023/2313503