Search Results - "Kustermann, S."

A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects by Kustermann, S., Boess, F., Buness, A., Schmitz, M., Watzele, M., Weiser, T., Singer, T., Suter, L., Roth, A.

“…► A novel impedance based real-time cytotoxicity assay has been established. ► An analysis algorithm for impedance data has been developed. ► Cytotoxic and…”
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Characterizing Adversity of Lysosomal Accumulation in Nonclinical Toxicity Studies: Results from the 5th ESTP International Expert Workshop by Lenz, B., Braendli-Baiocco, A., Engelhardt, J., Fant, P., Fischer, H., Francke, S., Fukuda, R., Gröters, S., Harada, T., Harleman, H., Kaufmann, W., Kustermann, S., Nolte, T., Palazzi, X., Pohlmeyer-Esch, G., Popp, A., Romeike, A., Schulte, A., Lima, B. Silva, Tomlinson, L., Willard, J., Wood, C. E., Yoshida, M.

“…Lysosomes have a central role in cellular catabolism, trafficking, and processing of foreign particles. Accumulation of endogenous and exogenous materials in…”
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Minimizing DILI risk in drug discovery — A screening tool for drug candidates by Schadt, S., Simon, S., Kustermann, S., Boess, F., McGinnis, C., Brink, A., Lieven, R., Fowler, S., Youdim, K., Ullah, M., Marschmann, M., Zihlmann, C., Siegrist, Y.M., Cascais, A.C., Di Lenarda, E., Durr, E., Schaub, N., Ang, X., Starke, V., Singer, T., Alvarez-Sanchez, R., Roth, A.B., Schuler, F., Funk, C.

“…Drug-induced liver injury (DILI) is a leading cause of acute hepatic failure and a major reason for market withdrawal of drugs. Idiosyncratic DILI is…”
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Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse by Sancho-Pelluz, J, Alavi, M V, Sahaboglu, A, Kustermann, S, Farinelli, P, Azadi, S, van Veen, T, Romero, F J, Paquet-Durand, F, Ekström, P

“…Inherited retinal degenerations, collectively termed retinitis pigmentosa (RP), constitute one of the leading causes of blindness in the developed world. RP is…”
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S-24-04 Novel in vitro models to address toxicity in the eye and brain by Dernick, K., Lange, S., Hoeber, J., Loskil, P., Kustermann, S.

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Hereditary ataxias and paraplegias in Valle d'Aosta, Italy: a study of prevalence and disability by Leone, M, Bottacchi, E, D'Alessandro, G, Kustermann, S

“…a study was conducted in the Valle d'Aosta Region, Italy, (115270 inhabitants) to determine the prevalence of hereditary ataxias (HA) and hereditary spastic…”
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Human iPSC-derived retinal organoid model for in vitro toxicity screening by Chichagova, V., Dorgau, B., de Santis, C., Georgiou, M., Carter, M, Hilgen, G., Collin, J., Queen, R., Chung, G., Ajeian, J., Moya-Molina, M, Kustermann, S., Pognan, F., Hewitt, P., Schmitt, M, Sernagor, E., Armstrong, L., Lako, M.

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Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration by Sancho-Pelluz, Javier, Arango-Gonzalez, Blanca, Kustermann, Stefan, Romero, Francisco Javier, van Veen, Theo, Zrenner, Eberhart, Ekström, Per, Paquet-Durand, François

“…Photoreceptor cell death is the major hallmark of a group of human inherited retinal degenerations commonly referred to as retinitis pigmentosa (RP). Although…”
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Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data by Krebs, Alice, Waldmann, Tanja, Wilks, Martin F, Van Vugt-Lussenburg, Barbara M A, Van der Burg, Bart, Terron, Andrea, Steger-Hartmann, Thomas, Ruegg, Joelle, Rovida, Costanza, Pedersen, Emma, Pallocca, Giorgia, Luijten, Mirjam, Leite, Sofia B, Kustermann, Stefan, Kamp, Hennicke, Hoeng, Julia, Hewitt, Philip, Herzler, Matthias, Hengstler, Jan G, Heinonen, Tuula, Hartung, Thomas, Hardy, Barry, Gantner, Florian, Fritsche, Ellen, Fant, Kristina, Ezendam, Janine, Exner, Thomas, Dunkern, Torsten, Dietrich, Daniel R, Coecke, Sandra, Busquet, Francois, Braeuning, Albert, Bondarenko, Olesja, Bennekou, Susanne H, Beilmann, Mario, Leist, Marcel

“…Only few cell-based test methods are described by Organisation for Economic Co-operation and Development (OECD) test guidelines or other regulatory references…”
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Importance of adaption-time to galactose-medium for accurate in vitro assessment of mitochondrial toxicity by Dernick, K., Boess, F., Singer, T., Schuler, F., Roth, A., Kustermann, S.

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P079 Perfused intestinal tubules for real-time assessment of drug-induced barrier disruption by Trietsch, S, Naumowska, E, Kurek, D, Setyawati, M, Vormann, M, Wilschut, K, Lanz, H, Nicolas, A, Ping Ng, C, Joore, J, Kustermann, S, Roth, A, Hankemeier, T, Moisan, A, Vulto, P

“…Abstract Background In vitro epithelial barrier models that are more representative of in vivo tissues are urgently needed. Methods Here we present…”
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Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data by Krebs, Alice, Waldmann, Tanja, Wilks, Martin F, Van Vugt-Lussenburg, Barbara M A, Van der Burg, Bart, Terron, Andrea, Steger-Hartmann, Thomas, Ruegg, Joelle, Rovida, Costanza, Pedersen, Emma, Pallocca, Giorgia, Luijten, Mirjam, Leite, Sofia B, Kustermann, Stefan, Kamp, Hennicke, Hoeng, Julia, Hewitt, Philip, Herzler, Matthias, Hengstler, Jan G, Heinonen, Tuula, Hartung, Thomas, Hardy, Barry, Gantner, Florian, Fritsche, Ellen, Fant, Kristina, Ezendam, Janine, Exner, Thomas, Dunkern, Torsten, Dietrich, Daniel R, Coecke, Sandra, Busquet, Francois, Braeuning, Albert, Bondarenko, Olesja, Bennekou, Susanne H, Beilmann, Mario, Leist, Marcel

“…In this manuscript, which appeared in ALTEX (2019), 36(4), 682- 699, doi:10.14573/altex.1909271 , the affiliation of Hennicke Kamp should be Experimental…”
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Hostility during admission interview as a short-term predictor of aggression in acute psychiatric male inpatients by TROISI, Alfonso, KUSTERMANN, Stefano, DI GENIO, Massimo, SIRACUSANO, Alberto

“…A critical step for improving the prediction of on-ward violence is the identification of variables that are not only consistently associated with an increased…”
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