Search Results - "Kusmierek, Jaroslaw T"

1,N 6 -α-hydroxypropanoadenine, the acrolein adduct to adenine, is a substrate for AlkB dioxygenase by Dylewska, Małgorzata, Kuśmierek, Jarosław T, Pilżys, Tomasz, Poznański, Jarosław, Maciejewska, Agnieszka M

“…1,N -α-hydroxypropanoadenine (HPA) is an exocyclic DNA adduct of acrolein - an environmental pollutant and endocellular oxidative stress product. AlkB…”
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Contribution of hMTH1 to the Maintenance of 8-Oxoguanine Levels in Lung DNA of Non–Small-Cell Lung Cancer Patients by Speina, Elżbieta, Arczewska, Katarzyna D., Gackowski, Daniel, Zielińska, Maja, Siomek, Agnieszka, Kowalewski, Janusz, Oliński, Ryszard, Tudek, Barbara, Kuśmierek, Jarosław T.

“…Background: The level of 8-oxoguanine (8-oxoG), a general marker of oxidative DNA damage, in DNA is the result of both an equilibrium between the rates of its…”
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The role of AlkB protein in repair of 1,N6-ethenoadenine in Escherichia coli cells by MACIEJEWSKA, Agnieszka M, SOKOLOWSKA, Beata, NOWICKI, Adam, KUSMIEREK, Jarostaw T

“…Etheno (ε) DNA adducts, including 1,N(6)-ethenoadenine (εA), are formed by various bifunctional agents of exogenous and endogenous origin. The AT→TA…”
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Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal by Maddukuri, Leena, Speina, Elzbieta, Christiansen, Mette, Dudzińska, Dominika, Zaim, Jolanta, Obtułowicz, Tomasz, Kabaczyk, Sylwia, Komisarski, Marek, Bukowy, Zuzanna, Szczegielniak, Jadwiga, Wójcik, Andrzej, Kuśmierek, Jaroslaw T, Stevnsner, Tinna, Bohr, Vilhelm A, Tudek, Barbara

“…Cockayne syndrome complementation group B (CSB) protein is engaged in transcription-coupled repair (TCR) of UV induced DNA damage and its deficiency leads to…”
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AlkB dioxygenase preferentially repairs protonated substrates: specificity against exocyclic adducts and molecular mechanism of action by Maciejewska, Agnieszka M, Poznanski, Jaroslaw, Kaczmarska, Zuzanna, Krowisz, Beata, Nieminuszczy, Jadwiga, Polkowska-Nowakowska, Agnieszka, Grzesiuk, Elzbieta, Kusmierek, Jaroslaw T

“…Efficient repair by Escherichia coli AlkB dioxygenase of exocyclic DNA adducts 3,N(4)-ethenocytosine, 1,N(6)-ethenoadenine, 3,N(4)-α-hydroxyethanocytosine, and…”
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Synthesis and properties of N2,3-ethenoguanosine and N2,3-ethenoguanosine 5'-diphosphate by Kusmierek, Jaroslaw T, Jensen, David E, Spengler, Sylvia J, Stolarski, Ryszard, Singer, B

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Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability by Arczewska, Katarzyna D., Baumeier, Christian, Kassahun, Henok, SenGupta, Tanima, Bjørås, Magnar, Kuśmierek, Jarosław T., Nilsen, Hilde

“…MutT enzymes prevent DNA damage by hydrolysis of 8-oxodGTP, an oxidized substrate for DNA synthesis and antimutagenic, anticarcinogenic, and…”
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Preparation of O'-alkyl derivatives of cytosine and uracil nucleosides by Kusmierek, Jaroslaw T, Giziewicz, Jerzy, Shugar, David

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Practical highly enantioselective synthesis of (R)- and (S)-(E)-4-hydroxynon-2-enal by Komisarski, Marek, Kaczmarska, Zuzanna, Kuśmierek, Jarosław T

“…Oxidative stress enhances lipid peroxidation (LPO) implicated in cancer promotion and progression. (E)-4-Hydroxynon-2-enal 1 (trans-4-hydroxy-2-nonenal, HNE)…”
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Bacterial DNA repair genes and their eukaryotic homologues: 2. Role of bacterial mutator gene homologues in human disease. Overview of nucleotide pool sanitization and mismatch repair systems by Arczewska, Katarzyna D, Kuśmierek, Jarosław T

“…Since the discovery of the first E. coli mutator gene, mutT, most of the mutations inducing elevated spontaneous mutation rates could be clearly attributed to…”
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The role of AlkB protein in repair of 1,N super(6)-ethenoadenine in Escherichia coli cells by Maciejewska, Agnieszka M, Sokolowska, Beata, Nowicki, Adam, Kusmierek, Jaroslaw T

“…Etheno ( epsilon ) DNA adducts, including 1,N super(6)-ethenoadenine ( epsilon A), are formed by various bifunctional agents of exogenous and endogenous…”
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Activity of Escherichia coli DNA-glycosylases on DNA damaged by methylating and ethylating agents and influence of 3-substituted adenine derivatives by Tudek, Barbara, VanZeeland, Albert A, Kusmierek, Jaroslaw T, Laval, Jacques

“…Methylating and ethylating agents are used in the chemical industry and produced during tobacco smoking. They generate DNA base damage whose role in cancer…”
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5'-O-methyl derivatives of 1-.beta.-D-arabinofuranosylcytosine and 1-.beta.-D-arabinofuranosyluracil by Giziewicz, Jerzy, Kusmierek, Jaroslaw T, Shugar, David

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Long-chain adducts of trans-4-hydroxy-2-nonenal to DNA bases cause recombination, base substitutions and frameshift mutations in M13 phage by Kowalczyk, Pawel, Cieśla, Jarosław M, Komisarski, Marek, Kuśmierek, Jarosław T, Tudek, Barbara

“…Oxidative stress enhances lipid peroxidation (LPO) implicated in the promotion and progression of carcinogenesis. One of the major LPO products is…”
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Neighbouring bases in template influence base-pairing of isoguanine by Maciejewska, Agnieszka M, Lichota, Katarzyna D, Kuśmierek, Jarosław T

“…Assuming that the efficiency of the incorporation of 5-methyl-2'-deoxyisocytosine-5' triphosphate (dMiCTP) and dTTP opposite isoguanine (iG) is a measure of…”
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Mismatch dependent uracil/thymine-DNA glycosylases excise exocyclic hydroxyethano and hydroxypropano cytosine adducts by Borys-Brzywczy, Ewa, Arczewska, Katarzyna D, Saparbaev, Murat, Hardeland, Ulrike, Schär, Primo, Kuśmierek, Jarosław T

“…Exocyclic adducts of DNA bases, such as etheno- and hydroxyalkano- ones, are generated by a variety of bifunctional agents, including endogenously formed…”
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The Pyrimidine Ring-opened Derivative of 1,N 6-Ethenoadenine Is Excised from DNA by theEscherichia coli Fpg and Nth Proteins by Speina, Elz˙bieta, Cieśla, Jarosław M., Wójcik, Jacek, Bajek, Monika, Kuśmierek, Jarosław T., Tudek, Barbara

“…It was previously shown that 1, N 6 -ethenoadenine (εA) in DNA rearranges into a pyrimidine ring-opened derivative of 20-fold higher mutagenic potency in…”
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Chloroacetaldehyde-induced mutagenesis in Escherichia coli: the role of AlkB protein in repair of 3,N(4)-ethenocytosine and 3,N(4)-alpha-hydroxyethanocytosine by Maciejewska, Agnieszka M, Ruszel, Karol P, Nieminuszczy, Jadwiga, Lewicka, Joanna, Sokołowska, Beata, Grzesiuk, Elzbieta, Kuśmierek, Jarosław T

“…Etheno (epsilon) adducts are formed in reaction of DNA bases with various environmental carcinogens and endogenously created products of lipid peroxidation…”
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Chloroacetaldehyde-induced mutagenesis in Escherichia coli: specificity of mutations and modulation by induction of the adaptive response to alkylating agents by Mroczkowska, M M, Kolasa, I K, Kusmierek, J T

“…The mutational specificity of chloroacetaldehyde (CAA), one of the metabolites of the human carcinogen vinyl chloride (VC), has been determined through the…”
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Synthesis, conformation, and spectroscopy of nucleoside analogues concerning their antiviral activity by Kuśmierek, Jarosław T, Stolarski, Ryszard

“…Chemically modified analogues of nucleosides and nucleotides, have been thoroughly investigated since the discovery of DNA double helix by Watson and Crick in…”
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