Search Results - "Kushwaha, Susheela"

Immunization of Mastomys coucha with Brugia malayi recombinant trehalose-6-phosphate phosphatase results in significant protection against homologous challenge infection by Kushwaha, Susheela, Singh, Prashant Kumar, Rana, Ajay Kumar, Misra-Bhattacharya, Shailja

“…Development of a vaccine to prevent or reduce parasite development in lymphatic filariasis would be a complementary approach to existing chemotherapeutic…”
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In vitro silencing of Brugia malayi trehalose-6-phosphate phosphatase impairs embryogenesis and in vivo development of infective larvae in jirds by Kushwaha, Susheela, Singh, Prashant Kumar, Shahab, Mohd, Pathak, Manisha, Bhattacharya, Shailja Misra

“…The trehalose metabolic enzymes have been considered as potential targets for drug or vaccine in several organisms such as Mycobacterium, plant nematodes,…”
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Cloning, expression, purification and kinetics of trehalose-6-phosphate phosphatase of filarial parasite Brugia malayi by Kushwaha, Susheela, Singh, Prashant K., Rana, Ajay K., Misra-Bhattacharya, Shailja

“…Trehalose-6-phosphate phosphatase from B. malayi was cloned, expressed and purified. Its unusual phosphatase activity and absence in mammals demonstrated its…”
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In vitro gene silencing of independent phosphoglycerate mutase (iPGM) in the filarial parasite Brugia malayi by Singh, Prashant Kumar, Kushwaha, Susheela, Mohd, Shahab, Pathak, Manisha, Misra-Bhattacharya, Shailja

“…Background The phosphoglycerate mutase (PGM) enzyme catalyzes the interconversion of 2- and 3-phosphoglycerate in the glycolytic /gluconeogenic pathways that…”
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Adult Brugia malayi ∼ 34 kDa (BMT-5) antigen offers Th1 mediated significant protection against infective larval challenge in Mastomys coucha by Shakya, Shilpy, Kumar Singh, Prashant, Kushwaha, Susheela, Misra-Bhattacharya, Shailja

“…Abstract We earlier reported a sizeable protection conferred by ‘mitochondria rich’ (MT) fraction of adult B. malayi and the present study was planned to…”
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Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1/Th2 Type Immune Response and Inhibits Larval Development in the Host by Singh, Prashant K., Kushwaha, Susheela, Rana, Ajay K., Misra-Bhattacharya, Shailja

“…Lymphatic filariasis is a major debilitating disease, endemic in 72 countries putting more than 1.39 billion people at risk and 120 million are already…”
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Recombinant trehalose-6-phosphate phosphatase of Brugia malayi cross-reacts with human Wuchereria bancrofti immune sera and engenders a robust protective outcome in mice by Kushwaha, Susheela, Singh, Prashant Kumar, Gupta, Jyoti, Soni, Vishal Kumar, Misra-Bhattacharya, Shailja

“…Trehalose-6-phosphate phosphatase of Brugia malayi (Bm-TPP) represents an attractive vaccine candidate because it is present in all the major life stages of…”
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Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice by Kushwaha, Susheela, Roy, Saptarshi, Maity, Rita, Mallick, Asish, Soni, Vishal K, Singh, Prashant K, Chaurasiya, Narayan D, Sangwan, Rajender S, Misra-Bhattacharya, Shailja, Mandal, Chitra

“…Abstract Withania somnifera (Ashwagandha) is a plant with known ethnomedicinal properties and its use in Ayurvedic medicine in India is well documented. The…”
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Immunological evaluation of an rsmD-like rRNA methyltransferase from Wolbachia endosymbiont of Brugia malayi by Rana, Ajay Kumar, Kushwaha, Susheela, Singh, Prashant Kumar, Misra-Bhattacharya, Shailja

“…Highlights • Immunologic response of a drug target, rsmD-like rRNA methyltransferase from Wolbachia endosymbiont of Brugia malayi. • The recombinant protein…”
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Immunization with a multisubunit vaccine considerably reduces establishment of infective larvae in a rodent model of Brugia malayi by Shrivastava, Nidhi, Singh, Prashant Kumar, Nag, Jeetendra Kumar, Kushwaha, Susheela, Misra-Bhattacharya, Shailja

“…Abstract Although recombinant vaccines have several advantages over conventional vaccines, protection induced by single antigen vaccines is often inadequate…”
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Chemotypical variations inWithania somniferalead to differentially modulated immune response in BALB/c mice by Kushwaha, Susheela, Roy, Saptarshi, Maity, Rita, Mallick, Asish, Soni, Vishal K, Singh, Prashant K, Chaurasiya, Narayan D, Sangwan, Rajender S, Misra-Bhattacharya, Shailja, Mandal, Chitra

“…Withania somnifera(Ashwagandha) is a plant with known ethnomedicinal properties and its use in Ayurvedic medicine in India is well documented. The present…”
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Towards novel antifilarial drugs: challenges and recent developments by Singh, Prashant Kumar, Ajay, Arya, Kushwaha, Susheela, Tripathi, Rama Pati, Misra-Bhattacharya, Shailja

“…Filariasis is caused by thread-like nematode worms, classified according to their presence in the vertebrate host. The cutaneous group includes Onchocerca…”
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Withania somnifera chemotypes NMITLI 101R, NMITLI 118R, NMITLI 128R and Withaferin A protect Mastomys coucha from Brugia malayi infection by Kushwaha, Susheela, Soni, Vishal Kumar, Singh, Prashant Kumar, Bano, Nasreen, Kumar, Anil, Sangwan, Rajendra Singh, Bhattacharya, Shailja‐Misra

“…Withania somnifera is an Ayurvedic Indian medicinal plant whose immunomodulatory activities have been widely used as a home remedy for several ailments. We…”
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Immunization of Mastomys coucha with Brugia malayi Recombinant Trehalose-6-Phosphate Phosphatase Results in Significant Protection against Homologous Challenge Infection: e72585 by Kushwaha, Susheela, Singh, Prashant Kumar, Rana, Ajay Kumar, Misra-Bhattacharya, Shailja

“…Development of a vaccine to prevent or reduce parasite development in lymphatic filariasis would be a complementary approach to existing chemotherapeutic…”
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Adult Brugia malayi approximately 34 kDa (BMT-5) antigen offers Th1 mediated significant protection against infective larval challenge in Mastomys coucha by Shakya, Shilpy, Singh, Prashant Kumar, Kushwaha, Susheela, Misra-Bhattacharya, Shailja

“…We earlier reported a sizeable protection conferred by 'mitochondria rich' (MT) fraction of adult B. malayi and the present study was planned to locate the…”
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