Search Results - "Kushner, P. J"

A robust empirical seasonal prediction of winter NAO and surface climate by Wang, L., Ting, M., Kushner, P. J.

“…A key determinant of winter weather and climate in Europe and North America is the North Atlantic Oscillation (NAO), the dominant mode of atmospheric…”
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Characterization of Northern Hemisphere Snow Water Equivalent Datasets, 1981–2010 by Mudryk, L. R., Derksen, C., Kushner, P. J., Brown, R.

“…Five, daily, gridded, Northern Hemisphere snow water equivalent (SWE) datasets are analyzed over the 1981–2010 period in order to quantify the spatial and…”
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Snow cover response to temperature in observational and climate model ensembles by Mudryk, L. R., Kushner, P. J., Derksen, C., Thackeray, C.

“…The relationship between land surface temperature and snow cover extent trends is examined in three distinct types of ensembles over the 1981–2010 period: an…”
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Remarkable separability of circulation response to Arctic sea ice loss and greenhouse gas forcing by McCusker, K. E., Kushner, P. J., Fyfe, J. C., Sigmond, M., Kharin, V. V., Bitz, C. M.

“…Arctic sea ice loss may influence midlatitude climate by changing large‐scale circulation. The extent to which climate change can be understood as greenhouse…”
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Constraining Reanalysis Snowfall Over the Arctic Ocean Using CloudSat Observations by Cabaj, A., Kushner, P. J., Fletcher, C. G., Howell, S., Petty, A. A.

“…In the absence of widespread snowfall observations over the Arctic Ocean, reanalysis products provide a wide range of estimates of time‐evolving snowfall rates…”
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THE COMMUNITY EARTH SYSTEM MODEL: A Framework for Collaborative Research by Hurrell, James W., Holland, M. M., Gent, P. R., Ghan, S., Kay, Jennifer E., Kushner, P. J., Lamarque, J.-F., Large, W. G., Lawrence, D., Lindsay, K., Lipscomb, W. H., Long, M. C., Mahowald, N., Marsh, D. R., Neale, R. B., Rasch, P., Vavrus, S., Vertenstein, M., Bader, D., Collins, W. D., Hack, J. J., Kiehl, J., Marshall, S.

“…The Community Earth System Model (CESM) is a flexible and extensible community tool used to investigate a diverse set of Earth system interactions across…”
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Interpreting observed northern hemisphere snow trends with large ensembles of climate simulations by Mudryk, L. R, Kushner, P. J, Derksen, C

“…Simulated variability and trends in Northern Hemisphere seasonal snow cover are analyzed in large ensembles of climate integrations of the National Center for…”
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Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity by Fanning, S. W., Hodges-Gallagher, L., Myles, D. C., Sun, R., Fowler, C. E., Plant, I. N., Green, B. D., Harmon, C. L., Greene, G. L., Kushner, P. J.

“…Complex tissue-specific and cell-specific signaling by the estrogen receptor (ER) frequently leads to the development of resistance to endocrine therapy for…”
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Modeling and understanding persistence of climate variability by Vyushin, D. I., Kushner, P. J., Zwiers, Francis

“…In this study, two parsimonious statistical representations of climate variability on interannual to multidecadal timescales are compared: the short‐memory…”
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Isentropic constraints by midlatitude surface warming on the Arctic midtroposphere by Laliberté, F., Kushner, P. J.

“…In simulations of 21st century climate, it is argued that changes in midlatitude near‐surface moisture and temperature could explain the autumn midtropospheric…”
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High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis by McClain, D A, Abraham, D, Rogers, J, Brady, R, Gault, P, Ajioka, R, Kushner, J P

“…The prevalence and mechanisms of diabetes in hereditary haemochromatosis are not known. We therefore measured glucose tolerance, insulin secretory capacity and…”
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Impact of sudden Arctic sea-ice loss on stratospheric polar ozone recovery by Scinocca, J. F., Reader, M. C., Plummer, D. A., Sigmond, M., Kushner, P. J., Shepherd, T. G., Ravishankara, A. R.

“…We investigate the sensitivity of Northern Hemisphere polar ozone recovery to a scenario in which there is rapid loss of Arctic summer sea ice in the first…”
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Southern Hemisphere Atmospheric Circulation Response to Global Warming by Kushner, Paul J., Held, Isaac M., Delworth, Thomas L.

“…The response of the Southern Hemisphere (SH), extratropical, atmospheric general circulation to transient, anthropogenic, greenhouse warming is investigated in…”
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Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis by ABRAHAM, D, ROGERS, J, GAULT, P, KUSHNER, J. P, MCCLAIN, D. A

“…We recently demonstrated that humans with hereditary haemochromatosis have decreased insulin secretory capacity with a compensatory increase in insulin…”
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Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor by Cavaillès, V., Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Kushner, P. J., Parker, M. G.

“…A conserved region in the hormone‐dependent activation domain AF2 of nuclear receptors plays an important role in transcriptional activation. We have…”
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Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites by Paech, Kolja, Webb, Paul, George G. J. M. Kuiper, Nilsson, Stefan, Gustafsson, Jan-Åke, Kushner, Peter J., Scanlan, Thomas S.

“…The transactivation properties of the two estrogen receptors, ERα and ERβ, were examined with different ligands in the context of an estrogen response element…”
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Review of simulations of climate variability and change with the GFDL R30 coupled climate model by DELWORTH, T. L, STOUFFER, R. J, DIXON, K. W, SPELMAN, M. J, KNUTSON, T. R, BROCCOLI, A. J, KUSHNER, P. J, WETHERALD, R. T

“…A review is presented of the development and simulation characteristics of the most recent version of a global coupled model for climate variability and change…”
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Summertime climate response to mountain pine beetle disturbance in British Columbia by Maness, H., Kushner, P. J., Fung, I.

“…The present mountain pine beetle infestation in forests in British Columbia ranks among the largest ecological disturbances recorded in Canada so far. These…”
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Regional variability of a projected sea ice‐free Arctic during the summer months by Laliberté, F., Howell, S. E. L., Kushner, P. J.

“…Climate projections of sea ice retreat under anthropogenic climate change at the regional scale and in summer months other than September have largely not been…”
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Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors by Feng, Weijun, Ralff C. J. Ribeiro, Wagner, Richard L., Nguyen, Hoa, Apriletti, James W., Fletterick, Robert J., Baxter, John D., Kushner, Peter J., West, Brian L.

“…The ligand-binding domain of nuclear receptors contains a transcriptional activation function (AF-2) that mediates hormone-dependent binding of coactivator…”
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