Search Results - "Kushner, Jake A."

Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age by RANKIN, Matthew M, KUSHNER, Jake A

“…Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age Matthew M. Rankin and Jake A. Kushner From the Division of Endocrinology and Diabetes,…”
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miR-211 Is a Prosurvival MicroRNA that Regulates chop Expression in a PERK-Dependent Manner by Chitnis, Nilesh S., Pytel, Dariusz, Bobrovnikova-Marjon, Ekaterina, Pant, Dhruv, Zheng, Hui, Maas, Nancy L., Frederick, Brian, Kushner, Jake A., Chodosh, Lewis A., Koumenis, Constantinos, Fuchs, Serge Y., Diehl, J. Alan

“…MicroRNAs typically function at the level of posttranscriptional gene silencing within the cytoplasm; however, increasing evidence suggests that they may also…”
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Letter to the Editor Re: Scott S.N., et al. Nutrients 2019, 11(5), 1022 by Kushner, Jake A

“…I read with great interest the thoughtful review concerning the potential impact of carbohydrate restriction in type 1 diabetes on glycaemic parameters and…”
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The Diabetes Susceptibility Gene Clec16a Regulates Mitophagy by Soleimanpour, Scott A., Gupta, Aditi, Bakay, Marina, Ferrari, Alana M., Groff, David N., Fadista, João, Spruce, Lynn A., Kushner, Jake A., Groop, Leif, Seeholzer, Steven H., Kaufman, Brett A., Hakonarson, Hakon, Stoffers, Doris A.

“…Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown…”
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Stem Cells to Insulin Secreting Cells: Two Steps Forward and Now a Time to Pause? by Kushner, Jake A., MacDonald, Patrick E., Atkinson, Mark A.

“…Two groups recently reported the in vitro differentiation of human embryonic stem cells into insulin-secreting cells, achieving an elusive goal for…”
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Tamoxifen suppresses pancreatic β-cell proliferation in mice by Ahn, Surl-Hee, Granger, Anne, Rankin, Matthew M, Lam, Carol J, Cox, Aaron R, Kushner, Jake A

“…Tamoxifen is a mixed agonist/antagonist estrogen analogue that is frequently used to induce conditional gene deletion in mice using Cre-loxP mediated gene…”
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Type I interferons mediate pancreatic toxicities of PERK inhibition by Yu, Qiujing, Zhao, Bin, Gui, Jun, Katlinski, Kanstantsin V., Brice, Angela, Gao, Yan, Li, ChangHong, Kushner, Jake A., Koumenis, Constantinos, Diehl, J. Alan, Fuchs, Serge Y.

“…The great preclinical promise of the pancreatic endoplasmic reticulum kinase (PERK) inhibitors in neurodegenerative disorders and cancers is marred by…”
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PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis by Gao, Yan, Sartori, Daniel J., Li, Changhong, Yu, Qian-Chun, Kushner, Jake A., Simon, M. Celeste, Diehl, J. Alan

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Very Slow Turnover of β-Cells in Aged Adult Mice by TETA, Monica, LONG, Simon Y, WARTSCHOW, Lynn M, RANKIN, Matthew M, KUSHNER, Jake A

“…Very Slow Turnover of β-Cells in Aged Adult Mice Monica Teta 1 , Simon Y. Long 1 , Lynn M. Wartschow 2 , Matthew M. Rankin 1 and Jake A. Kushner 1 1 Division…”
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Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention by Michels, Aaron, Zhang, Li, Khadra, Anmar, Kushner, Jake A., Redondo, Maria J., Pietropaolo, Massimo

“…Type 1 diabetes mellitus (T1DM) is the archetypal example of a T cell‐mediated autoimmune disease characterized by selective destruction of pancreatic β cells…”
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Identifying and addressing gaps in reproductive health education for adolescent girls with type 1 diabetes by Kohn, Jaden R, Hilliard, Marisa E, Lyons, Sarah K, Fox, Karin A, Kushner, Jake A

“…Adolescent girls with diabetes are at risk for adverse pregnancy outcomes due to age, risk-taking behavior, poor glycemic control, and lack of knowledge. Our…”
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Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals by Pawlak, Dorota B, Kushner, Jake A, Ludwig, David S

“…Clinical studies suggest a role for dietary glycaemic index (GI) in bodyweight regulation and diabetes risk. However, partly because manipulation of GI can…”
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CLEC16A regulates splenocyte and NK cell function in part through MEK signaling by Pandey, Rahul, Bakay, Marina, Hain, Heather S, Strenkowski, Bryan, Elsaqa, Barakat Z B, Roizen, Jeffrey D, Kushner, Jake A, Orange, Jordan S, Hakonarson, Hakon

“…CLEC16A is implicated in multiple autoimmune diseases. We generated Clec16a inducible knockout (KO) mice to examine the functional link between CLEC16A…”
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Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy by Cox, Aaron R, Barrandon, Ornella, Cai, Erica P, Rios, Jacqueline S, Chavez, Julia, Bonnyman, Claire W, Lam, Carol J, Yi, Peng, Melton, Douglas A, Kushner, Jake A

“…The β-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice induced…”
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The role of aging upon β cell turnover by Kushner, Jake A

“…Preservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both…”
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Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth by Kushner, Jake A., Ciemerych, Maria A., Sicinska, Ewa, Wartschow, Lynn M., Teta, Monica, Long, Simon Y., Sicinski, Piotr, White, Morris F.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Ductal Origin Hypothesis of Pancreatic Regeneration under Attack by Kushner, Jake A., Weir, Gordon C., Bonner-Weir, Susan

“…Although pancreatic β cells are known to expand by self-renewal in postnatal life, contribution by ductal progenitors remains vigorously debated. In a recent…”
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Extreme Beta-Cell Deficiency in Pancreata of Dogs with Canine Diabetes by Shields, Emily J, Lam, Carol J, Cox, Aaron R, Rankin, Matthew M, Van Winkle, Thomas J, Hess, Rebecka S, Kushner, Jake A

“…The pathophysiology of canine diabetes remains poorly understood, in part due to enigmatic clinical features and the lack of detailed histopathology studies…”
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The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice by Pandey, Rahul, Bakay, Marina, Hain, Heather S, Strenkowski, Bryan, Yermakova, Anastasiya, Kushner, Jake A, Orange, Jordan S, Hakonarson, Hakon

“…locus polymorphisms have been associated with several autoimmune diseases. We overexpressed in YTS natural killer (NK) cells and observed reduced NK cell…”
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Effects of Autoimmunity and Immune Therapy on β-Cell Turnover in Type 1 Diabetes by SHERRY, Nicole A, KUSHNER, Jake A, GLANDT, Mariela, KITAMURA, Tadahiro, BRILLANTES, Anne-Marie B, HEROLD, Kevan C

“…Effects of Autoimmunity and Immune Therapy on β-Cell Turnover in Type 1 Diabetes Nicole A. Sherry 1 , Jake A. Kushner 2 , Mariela Glandt 3 , Tadahiro Kitamura…”
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