Role for phagocytosis in the prevention of neoplastic transformation in Drosophila
Immunity is considered to be involved in the prevention of cancer. Although both humoral and cellular immune reactions may participate, underlying mechanisms have yet to be clarified. The present study was conducted to clarify this issue using a Drosophila model, in which neoplastic transformation w...
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| Published in: | Genes to cells : devoted to molecular & cellular mechanisms Vol. 25; no. 10; pp. 675 - 684 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Tokyo
Wiley Subscription Services, Inc
01-10-2020
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Immunity is considered to be involved in the prevention of cancer. Although both humoral and cellular immune reactions may participate, underlying mechanisms have yet to be clarified. The present study was conducted to clarify this issue using a Drosophila model, in which neoplastic transformation was induced through the simultaneous inhibition of cell‐cycle checkpoints and apoptosis. We first determined the location of hemocytes, blood cells of Drosophila playing a role of immune cells, in neoplasia‐induced and normal larvae, but there was no significant difference between the two groups. When gene expression pattern in larval hemocytes was determined, the expression of immunity‐related genes including those necessary for phagocytosis was reduced in the neoplasia model. We then asked the involvement of phagocytosis in the prevention of neoplasia examining animals where the expression of engulfment receptors instead of apoptosis was retarded. We found that the inhibition of engulfment receptor expression augmented the occurrence of neoplasia induced by a defect in cell‐cycle checkpoints. This suggested a role for phagocytosis in the prevention of neoplastic transformation in Drosophila.
Simultaneous inhibition of cell‐cycle checkpoints and apoptosis induces neoplastic transformation in Drosophila. Inhibition of engulfment receptor expression instead of apoptosis induces neoplasia. Phagocytosis plays a role in the prevention of neoplasia in Drosophila. |
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| Bibliography: | Funding information Communicated by: Shigeo Hayashi This work was supported by the KAKENHI grant from the Japan Society for the Promotion of Science [grant numbers 18K19395 to Yo.N.; 25440044 and 16K07726 to K.N.; 18H05099, 19H04956, and 19K06674 to T.Y.], and research grants from the Hokkoku Cancer Foundation (to Yo.N.), the Takeda Science Foundation (to T.Y.), and Hirosaki University Grant for Exploratory Research by Young Scientists and Newly‐appointed Scientists (to K.N.) ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1356-9597 1365-2443 |
| DOI: | 10.1111/gtc.12804 |