Search Results - "Kushida, Hirotaka"

Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook by Kushida, Hirotaka, Matsumoto, Takashi, Ikarashi, Yasushi

“…Uncaria Hook (UH) is a dry stem with hook of Ucaria plant and is contained in Traditional Japanese and Chinese medicine such as yokukansan,…”
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Comprehensive metabolome analysis for the pharmacological action of inchinkoto, a hepatoprotective herbal medicine by Yamashita, Hiromasa, Ohbuchi, Katsuya, Nagino, Masato, Ebata, Tomoki, Tsuchiya, Kazuaki, Kushida, Hirotaka, Yokoyama, Yukihiro

“…Introduction The precise pharmacological action of inchinkoto (ICKT, Yin-Chen-Hao-Tang in Chinese), a hepatoprotective herbal medicine, on total metabolic…”
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Differential annotation of converted metabolites (DAC-Met): Exploration of Maoto (Ma-huang-tang)-derived metabolites in plasma using high-resolution mass spectrometry by Ohbuchi, Katsuya, Sakurai, Nozomu, Kitagawa, Hiroyuki, Sato, Masaru, Suzuki, Hideyuki, Kushida, Hirotaka, Nishi, Akinori, Yamamoto, Masahiro, Hanazaki, Kazuhiro, Arita, Masanori

“…Introduction Traditional herbal medicine (THM) contains a vast number of natural compounds with varying degrees of pharmacological activity. To elucidate the…”
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In Vivo Pharmacokinetic Analysis Utilizing Non-Targeted and Targeted Mass Spectrometry and In Vitro Assay against Transient Receptor Potential Channels of Maobushisaishinto and Its Constituent Asiasari Radix by Matsumoto, Takashi, Takiyama, Mikina, Sanechika, Shou, Nakayama, Akiko, Aoki, Katsuyuki, Ohbuchi, Katsuya, Kushida, Hirotaka, Kanno, Hitomi, Nishi, Akinori, Watanabe, Junko

“…The Japanese traditional medicine maobushisaishinto (MBST) has been prescribed for treating upper respiratory tract infections, such as a common cold. However,…”
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Ginsenosides, ingredients of the root of Panax ginseng, are not substrates but inhibitors of sodium-glucose transporter 1 by Gao, Shengli, Kushida, Hirotaka, Makino, Toshiaki

“…Recent pharmacokinetic studies have revealed that ginsenosides, the major ingredients of ginseng (the roots of Panax ginseng ), are present in the plasma…”
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Phenotyping analysis of the Japanese Kampo medicine maoto in healthy human subjects using wide-targeted plasma metabolomics by Kitagawa, Hiroyuki, Ohbuchi, Katsuya, Munekage, Masaya, Fujisawa, Kazune, Kawanishi, Yasuhiro, Namikawa, Tsutomu, Kushida, Hirotaka, Matsumoto, Takashi, Shimobori, Chika, Nishi, Akinori, Sadakane, Chiharu, Watanabe, Junko, Yamamoto, Masahiro, Hanazaki, Kazuhiro

“…•Traditional herbal medicines consist of a vast number of compounds and are assumed to exert their activity by affecting various sites in the body.•Plasma…”
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Distribution Analysis via Mass Spectrometry Imaging of Ephedrine in the Lungs of Rats Orally Administered the Japanese Kampo Medicine Maoto by Matsumoto, Takashi, Kushida, Hirotaka, Matsushita, Shoko, Oyama, Yoshiyuki, Suda, Takafumi, Watanabe, Junko, Kase, Yoshio, Setou, Mitsutoshi

“…Maoto, a traditional Japanese Kampo medicine, has been used to treat various respiratory diseases, including respiratory infections and influenza. Ephedrine…”
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Specific binding and characteristics of geissoschizine methyl ether, an indole alkaloid of Uncaria Hook, in the rat brain by Mizoguchi, Kazushige, Kushida, Hirotaka, Kanno, Hitomi, Igarashi, Yasushi, Nishimura, Hiroaki, Ikarashi, Yasushi, Kase, Yoshio

“…Geissoschizine methyl ether (GM) is an indole alkaloid that is a component of Uncaria Hook, and has been identified as the active component responsible for the…”
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LimeMap: a comprehensive map of lipid mediator metabolic pathways by Nishi, Akinori, Ohbuchi, Katsuya, Kaifuchi, Noriko, Shimobori, Chika, Kushida, Hirotaka, Yamamoto, Masahiro, Kita, Yoshihiro, Tokuoka, Suzumi M., Yachie, Ayako, Matsuoka, Yukiko, Kitano, Hiroaki

“…Lipid mediators are major factors in multiple biological functions and are strongly associated with disease. Recent lipidomics approaches have made it possible…”
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The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan by Imamura, Sachiko, Tabuchi, Masahiro, Kushida, Hirotaka, Nishi, Akinori, Kanno, Hitomi, Yamaguchi, Takuji, Sekiguchi, Kyoji, Ikarashi, Yasushi, Kase, Yoshio

“…Geissoschizine methyl ether (GM) in Uncaria hook, a galenical constituent of yokukansan is thought to be one of active components in the psychotropic effect of…”
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Metabolic profiling of the Uncaria hook alkaloid geissoschizine methyl ether in rat and human liver microsomes using high-performance liquid chromatography with tandem mass spectrometry by Kushida, Hirotaka, Matsumoto, Takashi, Igarashi, Yasushi, Nishimura, Hiroaki, Watanabe, Junko, Maemura, Kazuya, Kase, Yoshio

“…Geissoschizine methyl ether (GM) is an indole alkaloid found in Uncaria hook, which is a galenical constituent of yokukansan, a traditional Japanese medicine…”
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Effects of shakuyakukanzoto and its absorbed components on twitch contractions induced by physiological Ca2+ release in rat skeletal muscle by Kaifuchi, Noriko, Omiya, Yuji, Kushida, Hirotaka, Fukutake, Miwako, Nishimura, Hiroaki, Kase, Yoshio

“…Shakuyakukanzoto (SKT) is a kampo medicine composed of equal proportions of Glycyrrhizae radix ( G . radix) and Paeoniae radix ( P . radix). A double-blind…”
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Publisher Correction: LimeMap: a comprehensive map of lipid mediator metabolic pathways by Nishi, Akinori, Ohbuchi, Katsuya, Kaifuchi, Noriko, Shimobori, Chika, Kushida, Hirotaka, Yamamoto, Masahiro, Kita, Yoshihiro, Tokuoka, Suzumi M., Yachie, Ayako, Matsuoka, Yukiko, Kitano, Hiroaki

“…A Correction to this paper has been published: https://doi.org/10.1038/s41540-021-00174-w…”
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Data on metabolic profiling of healthy human subjects’ plasma before and after administration of the Japanese Kampo medicine maoto by Kitagawa, Hiroyuki, Ohbuchi, Katsuya, Munekage, Masaya, Fujisawa, Kazune, Kawanishi, Yasuhiro, Namikawa, Tsutomu, Kushida, Hirotaka, Matsumoto, Takashi, Shimobori, Chika, Nishi, Akinori, Sadakane, Chiharu, Watanabe, Junko, Yamamoto, Masahiro, Hanazaki, Kazuhiro

“…This data article contains the data on metabolic profiling of healthy human subjects’ plasma before and after administration of the Japanese Kampo medicine…”
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Deconstructing the traditional Japanese medicine “Kampo”: compounds, metabolites and pharmacological profile of maoto, a remedy for flu-like symptoms by Nishi, Akinori, Ohbuchi, Katsuya, Kushida, Hirotaka, Matsumoto, Takashi, Lee, Keiko, Kuroki, Haruo, Nabeshima, Shigeki, Shimobori, Chika, Komokata, Nagisa, Kanno, Hitomi, Tsuchiya, Naoko, Zushi, Makoto, Hattori, Tomohisa, Yamamoto, Masahiro, Kase, Yoshio, Matsuoka, Yukiko, Kitano, Hiroaki

“…Pharmacological activities of the traditional Japanese herbal medicine (Kampo) are putatively mediated by complex interactions between multiple herbal…”
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The Influence of the Sennosides on Absorption of Glycyrrhetic Acid in Rats by Mizuhara, Yasuharu, Takizawa, Yukiho, Ishihara, Kazuhisa, Asano, Takayuki, Kushida, Hirotaka, Morota, Takashi, Kase, Yoshio, Takeda, Shuichi, Aburada, Masaki, Nomura, Masaaki, Yokogawa, Koichi

“…In the course of our clinical studies of Kampo medicine (traditional Japanese medicines), we observed the pharmacokinetic interactions between two herbs. When…”
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Gender differences in plasma pharmacokinetics and hepatic metabolism of geissoschizine methyl ether from Uncaria hook in rats by Kushida, Hirotaka, Matsumoto, Takashi, Ikarashi, Yasushi, Nishimura, Hiroaki, Yamamoto, Masahiro

“…Geissoschizine methyl ether (GM), an indole alkaloid from Uncaria hook, is an active ingredient in the traditional Japanese Kampo medicine yokukansan, which is…”
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Interaction of Drugs and Chinese Herbs: Pharmacokinetic Changes of Tolbutamide and Diazepam Caused by Extract of Angelica dahurica by ISHIHARA, KAZUHISA, KUSHIDA, HIROTAKA, YUZURIHARA, MITSUTOSHI, WAKUI, YOKO, YANAGISAWA, TOSHIHIKO, KAMEI, HIDEO, OHMORI, SHIGERU, KITADA, MITSUKAZU

“…The inhibitory effects of Angelica dahurica root extract on rat liver microsomal cytochrome P450 and drug‐drug interactions were studied. The 2α‐ and…”
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Metabolism of Ipecac Alkaloids Cephaeline and Emetine by Human Hepatic Microsomal Cytochrome P450s, and Their Inhibitory Effects on P450 Enzyme Activities by ASANO, Takayuki, KUSHIDA, Hirotaka, SADAKANE, Chiharu, ISHIHARA, Kazuhisa, WAKUI, Yoko, YANAGISAWA, Toshihiko, KIMURA, Masayuki, KAMEI, Hideo, YOSHIDA, Takemi

“…In this study, we identified the metabolites and the CYP forms that are specifically involved in emetine O-demethylation in human liver microsomes, and cleared…”
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Sa1562 NON-ALCOHOLIC STEATOHEPATITIS-ASSOCIATED ALTERATION OF INFLAMMATORY LIPID MEDIATORS, PRIMARY METABOLITES AND MICROBIOME IN A STAM MOUSE MODEL, AND THERAPEUTIC POTENTIAL OF A JAPANESE TRADITIONAL MEDICINE, DAISAIKOTO by Nishi, Akinori, Kaifuchi, Noriko, Ishizawa, Shiori, Nahata, Miwa, Yamada, Chihiro, Ohbuchi, Katsuya, Kushida, Hirotaka, Iizuka, Seiichi, Nishiyama, Mitsue, Fujitsuka, Naoki, Kaneko, Atsushi, Yamamoto, Masahiro, Taketomi, Akinobu, Kono, Toru

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