Search Results - "Kushch, A. A."

Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells by Vinogradskaya, G. R., Ivanov, A. V., Kushch, A. A

“…Human cytomegalovirus (HCMV) DNA and proteins are often detected in malignant tumors, warranting studies of the role that HCMV plays in carcinogenesis and…”
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The role of herpesviruses in development of diseases of the urogenital tract and infertility in women by Kushch, A. A., Kisteneva, L. B., Klimova, R. R., Cheshik, S. G.

“…This review presents the data on the spreading of all known human herpesviruses (НHVs) in female urogenital tract. According to the WHO almost 500 million…”
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Multi-objective optimization to evaluate tradeoffs among forest ecosystem services following fire hazard reduction in the Deschutes National Forest, USA by Schroder, Svetlana A. (Kushch), Tóth, Sándor F., Deal, Robert L., Ettl, Gregory J.

“…Forest owners worldwide are increasingly interested in managing forests to provide a broad suite of ecosystem services, balancing multiple objectives and…”
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Complete and Prolonged Inhibition of Herpes Simplex Virus Type 1 Infection In Vitro by CRISPR/Cas9 and CRISPR/CasX Systems by Karpov, Dmitry S, Demidova, Natalia A, Kulagin, Kirill A, Shuvalova, Anastasija I, Kovalev, Maxim A, Simonov, Ruslan A, Karpov, Vadim L, Snezhkina, Anastasiya V, Kudryavtseva, Anna V, Klimova, Regina R, Kushch, Alla A

“…Almost all people become infected with herpes viruses, including herpes simplex virus type 1 (HSV-1), during their lifetime. Typically, these viruses persist…”
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Daidzein-directed methionine γ-lyase in enzyme prodrug therapy against breast cancer by Morozova, E., Abo Qoura, L., Anufrieva, N., Koval, V., Lesnova, E., Kushch, A., Kulikova, V., Revtovich, S., Pokrovsky, V.S., Demidkina, T.

“…Thiosulfinates in situ formed by “pharmacological pair” C115H methionine γ-lyase/S-(allyl/alkyl)-l-cysteine sulfoxides possess cytotoxic activity against…”
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Preventive Vaccination with Mesenchymal Stem Cells Protects Mice from Lethal Infection Caused by Herpes Simplex Virus 1 by Klimova, R. R., Demidova, N. A., Masalova, O. V., Kushch, A. A.

“…Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect almost all organs and tissues, cause genital herpes—the most common sexually transmitted…”
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Mesenchymal Stem Cells Can Both Enhance and Inhibit the Cellular Response to DNA Immunization by Genes of Nonstructural Proteins of the Hepatitis C Virus by Masalova, Olga V, Lesnova, Ekaterina I, Klimova, Regina R, Ivanov, Alexander V, Kushch, Alla A

“…Despite extensive research, there is still no vaccine against the hepatitis C virus (HCV). The aim of this study was to investigate whether MSCs can exhibit…”
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Conjugates of methionine γ-lyase with polysialic acid: Two approaches to antitumor therapy by Morozova, E., Anufrieva, N., Koval, V., Lesnova, E., Kushch, A., Timofeeva, V., Solovieva, A., Kulikova, V., Revtovich, S., Demidkina, T.

“…The methionine dependence is a well known phenomenon in metabolism of cancer cells. Methionine γ-lyase (EC 4.4.1.11, MGL) catalyzes the γ-elimination reaction…”
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Effect of Panavir on Herpes simplex Virus Types 1 and 2 Proteins Synthesis in Cell Culture by R. R. Klimova, A. A. Kushch, N. E. Fedorova, A. A. Litvin

“…The effect of Panavir on the synthesis of ultraearly (α), early (β) and late (γ) proteins of Herpes simplex virus types 1 and 2 in the culture of Vero cells…”
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The adjuvant effect of polymuramil, a NOD1 and NOD2 agonist, differs when immunizing mice of different inbred lines with nonstructural hepatitis C virus (Flaviviridae: Hepacivirus)proteins and is synergistically enhanced in combination with pyrogenalum, a TLR4 agonist by Lesnova, Ekaterina I., Masalova, Olga V., Permyakova, Kristina Yu, Demidova, Natalia A., Valuev-Elliston, Vladimir T., Ivanov, Alexandr V., Kushch, Alla A.

“…Introduction. Hepatitis C is a liver disease with high chronicity, the cause of cirrhosis and hepatocarcinoma. The main obstacle to controlling hepatitis C is…”
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Difluoromethylornithine (DFMO), an Inhibitor of Polyamine Biosynthesis, and Antioxidant N -Acetylcysteine Potentiate Immune Response in Mice to the Recombinant Hepatitis C Virus NS5B Protein by Lesnova, Ekaterina I, Masalova, Olga V, Permyakova, Kristina Yu, Kozlov, Vyacheslav V, Nikolaeva, Tatyana N, Pronin, Alexander V, Valuev-Elliston, Vladimir T, Ivanov, Alexander V, Kushch, Alla A

“…Hepatitis C virus (HCV) is one of the main triggers of chronic liver disease. Despite tremendous progress in the HCV field, there is still no vaccine against…”
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Cytotoxicity and antiviral activity of tellurium derivatives in cells infected with herpes simplex virus and cytomegalovirus in vitro by Adieva, A. A., Klimova, R. R., Abakarov, G. M., Bekshokov, K. S., Fedorova, N. E., Omarova, D. K., Kushch, A. A., Dzhamalova, S. A., Khalimbekova, A. M., Guseynova, A. R.

“…Aim. To carry out a comparative analysis of the cytotoxic and antiviral properties of synthesized tellurium derivatives in model cellular systems of infections…”
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Obtaining and Characterization of the Monoclonal Antibodies Against G-Protein of the Respiratory Syncytial Virus by Demidova, N. A., Klimova, R. R., Kushch, A. A., Lesnova, E. I., Masalova, O. V., Dorofeeva, A. D., Nikonova, A. A., Fedorova, N. E., Zverev, V. V.

“…The aim of this study was to obtain hybridomas producing monoclonal antibodies (Mabs) to the G-protein of the respiratory syncytial virus (RSV), and to…”
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Detection rates and high concentration of herpesvirus (Orthoherpesviridae) DNA in autopsy materials from patients with COVID-19 fatal outcome by Yurlov, Kirill I., Yakushina, Sofia A., Fedorova, Natalya E., Kisteneva, Lidiia B., Kelly, Elena I., Kanibolotsky, Alexander A., Ivkin, Yevgeniy N., Antipiat, Natalia A., Turin, Igor N., Larichev, Victor F., Demidova, Natalia A., Lesnova, Ekaterina I., Klimova, Regina R., Masalova, Olga V., Kushch, Alla A.

“…Introduction. SARS-CoV-2 infection causes immune disorders that create conditions for the reactivation of human herpesviruses (HHVs). However, the estimates of…”
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Cytomegalovirus infection and male infertility: case report by Kovalyk, V. Р., Malinovskaya, V. V., Shuvalov, A. N., Kurilo, L. F., Yurlov, К. I., Gomberg, М A., Kushch, A. A.

“…Objectives. To present a case report of male infertility associated with cytomegalovirus infection and the outcome of antiviral treatment. Clinical…”
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Human Mesenchymal Stem Cells Modified with the NS5A Gene of Hepatitis C Virus Induce a Cellular Immune Response Exceeding the Response to DNA Immunization with This Gene by Masalova, Olga V, Lesnova, Ekaterina I, Kalsin, Vladimir A, Klimova, Regina R, Fedorova, Natalya E, Kozlov, Vyacheslav V, Demidova, Natalya A, Yurlov, Kirill I, Konoplyannikov, Mikhail A, Nikolaeva, Tatyana N, Pronin, Alexander V, Baklaushev, Vladimir P, Kushch, Alla A

“…Hepatitis C virus (HCV) is one of the basic culprits behind chronic liver disease, which may result in cirrhosis and hepatocarcinoma. In spite of the extensive…”
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MESENCHYMAL STEM CELLS ENHANCE IMMUNE RESPONSE AND PROTECTMICE AGAINST LETHAL HERPES VIRAL INFECTION by Klimova, R. R., Momotyuk, E. D., Demidova, N. A., Yarigina, E. I., Kushch, A. A.

“…The objective of this study was to evaluate immunoregulatory and protective potential of mesenchymal stem cells (MSC) in a mouse model of lethal HSV1…”
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vesicular stomatitis pseudovirus expressing the surface glycoproteins of influenza A virus by Cheresiz, S. V, Kononova, A. A, Razumova, Yu. V, Dubich, T. S, Chepurnov, A. A, Kushch, A. A, Davey, R, Pokrovsky, A. G

“…Pseudotyped viruses bearing the glycoprotein(s) of a donor virus over the nucleocapsid core of a surrogate virus are widely used as safe substitutes for…”
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Modulation of Cell Death Pathways by Hepatitis C Virus Proteins in Huh7.5 Hepatoma Cells by Masalova, Olga V, Lesnova, Ekaterina I, Solyev, Pavel N, Zakirova, Natalia F, Prassolov, Vladimir S, Kochetkov, Sergey N, Ivanov, Alexander V, Kushch, Alla A

“…The hepatitis C virus (HCV) causes chronic liver disease leading to fibrosis, cirrhosis, and hepatocellular carcinoma. HCV infection triggers various types of…”
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Human Herpesviruses Increase the Severity of Hepatitis by Yurlov, Kirill I., Masalova, Olga V., Kisteneva, Lidiia B., Khlopova, Irina N., Samokhvalov, Evgeny I., Malinovskaya, Valentina V., Parfyonov, Vladimir V., Shuvalov, Alexander N., Kushch, Alla A.

“…Acute and chronic liver diseases are a major global public health problem; nevertheless, the etiology of 12–30% of cases remains obscure. The purpose of this…”
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