Search Results - "Kushawaha, Pramod K"
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Leishmania donovani triose phosphate isomerase: a potential vaccine target against visceral leishmaniasis
Published in PloS one (24-09-2012)“…Visceral leishmaniasis (VL) is one of the most important parasitic diseases with approximately 350 million people at risk. Due to the non availability of an…”
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A novel recombinant Leishmania donovani p45, a partial coding region of methionine aminopeptidase, generates protective immunity by inducing a Th1 stimulatory response against experimental visceral leishmaniasis
Published in International journal for parasitology (01-05-2012)“…[Display omitted] ► Visceral leishmaniasis (VL) is a fatal disease of the disadvantaged on the Indian subcontinent. ► There is no vaccine to date and current…”
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Leishmania donovani secretory protein nucleoside diphosphate kinase b localizes in its nucleus and prevents ATP mediated cytolysis of macrophages
Published in Microbial pathogenesis (01-05-2022)“…Leishmania donovani pathogenicity is closely linked to its ability to live and replicate in the hostile environment of macrophages. All protozoan parasites,…”
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Elongation factor-2, a Th1 stimulatory protein of Leishmania donovani, generates strong IFN-γ and IL-12 response in cured Leishmania-infected patients/hamsters and protects hamsters against Leishmania challenge
Published in The Journal of immunology (1950) (15-12-2011)“…In visceral leishmaniasis, Th1 types of immune responses correlate with recovery from and resistance to disease, and resolution of infection results in…”
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Chandipura Virus Utilizes the Prosurvival Function of RelA NF-κB for Its Propagation
Published in Journal of virology (15-07-2019)“…Chandipura virus (CHPV), a cytoplasmic RNA virus, has been implicated in several outbreaks of acute encephalitis in India. Despite the relevance of CHPV to…”
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Treatment of Leishmania donovani-infected hamsters with miltefosine: analysis of cytokine mRNA expression by real-time PCR, lymphoproliferation, nitrite production and antibody responses
Published in Journal of antimicrobial chemotherapy (01-02-2012)“…Miltefosine, an orally effective antileishmanial drug, works directly on the parasite by impairing membrane synthesis and subsequent apoptosis of the parasite…”
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Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design
Published in Journal of antimicrobial chemotherapy (01-11-2008)“…Objectives The aim of this study was to resolve the putative pathway responsible for death induced by peganine hydrochloride dihydrate isolated from Peganum…”
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Comparative Analysis of Cellular Immune Responses in Treated Leishmania Patients and Hamsters against Recombinant Th1 Stimulatory Proteins of Leishmania donovani
Published in Frontiers in microbiology (22-03-2016)“…Our prior studies demonstrated that cellular response of T helper 1 (Th1) type was generated by a soluble antigenic fraction (ranging from 89.9 to 97.1 kDa) of…”
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Th1 stimulatory proteins of Leishmania donovani: comparative cellular and protective responses of rTriose phosphate isomerase, rProtein disulfide isomerase and rElongation factor-2 in combination with rHSP70 against visceral leishmaniasis
Published in PloS one (30-09-2014)“…In visceral leishmaniasis, the recovery from the disease is always associated with the generation of Th1-type of cellular responses. Based on this, we have…”
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