Search Results - "Kushal, Swati"

In vivo anticancer activity of rhomboidal Pt(II) metallacycles by Grishagin, Ivan V., Pollock, J. Bryant, Kushal, Swati, Cook, Timothy R., Stang, Peter J., Olenyuk, Bogdan Z.

“…Significance The design of new antitumor agents and the search for delivery vehicles for existing drugs are two problems in cancer therapy that are often…”
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Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling by Kushal, Swati, Lao, Brooke Bullock, Henchey, Laura K., Dubey, Ramin, Mesallati, Hanah, Traaseth, Nathaniel J., Olenyuk, Bogdan Z., Arora, Paramjit S.

“…Selective blockade of gene expression by designed small molecules is a fundamental challenge at the interface of chemistry, biology, and medicine…”
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Suppression of Tumor Growth by Designed Dimeric Epidithiodiketopiperazine Targeting Hypoxia-Inducible Transcription Factor Complex by Dubey, Ramin, Levin, Michael D, Szabo, Lajos Z, Laszlo, Csaba F, Kushal, Swati, Singh, Jason B, Oh, Philip, Schnitzer, Jan E, Olenyuk, Bogdan Z

“…Hypoxia is a hallmark of solid tumors, is associated with local invasion, metastatic spread, resistance to chemo- and radiotherapy, and is an independent,…”
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Streamlining the Detection of FLT3 Internal Tandem Duplication (FLT3-ITD) Using the Cepheid Genexpert® Automated System by Sirajuddin, Paul, Gregory, Austin, Kushal, Swati, Day, Gwo-Jen

“…Objectives: The development of targeted therapies for Acute Myeloid leukemia (AML) demands fast and reliable diagnostic tests. Specifically, FMS-like tyrosine…”
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Development of a Fast and Quantitative FLT3-TKD Mutation Prototype Using Lab in a Cartridge™ Technology by Kushal, Swati, Calayag, Kyle, Das, Suvarthi, Saatian, Behnaz, Xie, Guanyi, Bates, Michael, Day, Gwo-Jen

“…Introduction Acute myeloid leukemia (AML) is a heterogenous hematologic malignancy characterized by the rapid proliferation of abnormal myeloid cells in the…”
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Monoamine Oxidase A Inhibitor–Near-Infrared Dye Conjugate Reduces Prostate Tumor Growth by Wu, Jason Boyang, Lin, Tzu-Ping, Gallagher, John D, Kushal, Swati, Chung, Leland W. K, Zhau, Haiyen E, Olenyuk, Bogdan Z, Shih, Jean C

“…Development of anti-cancer agents with high tumor-targeting specificity and efficacy is critical for modern multidisciplinary cancer research. Monoamine…”
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Inhibition of Hypoxia Inducible Factor 1Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix by Henchey, Laura K, Kushal, Swati, Dubey, Ramin, Chapman, Ross N, Olenyuk, Bogdan Z, Arora, Paramjit S

“…Designed ligands that inhibit hypoxia-inducible gene expression could offer new tools for genomic research and, potentially, drug discovery efforts for the…”
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Monoamine oxidase A (MAO A) inhibitors decrease glioma progression by Kushal, Swati, Wang, Weijun, Vaikari, Vijaya Pooja, Kota, Rajesh, Chen, Kevin, Yeh, Tzu-Shao, Jhaveri, Niyati, Groshen, Susan L, Olenyuk, Bogdan Z, Chen, Thomas C, Hofman, Florence M, Shih, Jean C

“…Glioblastoma (GBM) is an aggressive brain tumor which is currently treated with temozolomide (TMZ). Tumors usually become resistant to TMZ and recur; no…”
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Tumor Targeting, Trifunctional Dendritic Wedge by Dubey, Ramin, Kushal, Swati, Mollard, Alexis, Vojtovich, Lesya, Oh, Philip, Levin, Michael D, Schnitzer, Jan E, Zharov, Ilya, Olenyuk, Bogdan Z

“…We report in vitro and in vivo evaluation of a newly designed trifunctional theranostic agent for targeting solid tumors. This agent combines a dendritic wedge…”
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Direct Inhibition of Hypoxia-Inducible Transcription Factor Complex with Designed Dimeric Epidithiodiketopiperazine by Block, Katherine M, Wang, Hui, Szabó, Lajos Z, Polaske, Nathan W, Henchey, Laura K, Dubey, Ramin, Kushal, Swati, László, Csaba F, Makhoul, Joshua, Song, Zuohe, Meuillet, Emmanuelle J, Olenyuk, Bogdan Z

“…Selective blockade of hypoxia-inducible gene expression by designed small molecules would prove valuable in suppressing tumor angiogenesis, metastasis and…”
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Abstract 289: Hydrogen bond surrogate (HBS) helices as orthosteric regulator of hypoxia inducible transcription by Kushal, Swati, Bullock, Brooke, Henchey, Laura, Arora, Paramjit, Olenyuk, Bogdan

“…Abstract Hypoxia-Inducible Factor (HIF-1) is a heterodimeric transcriptional activator which plays a critical role in tumorigenesis and therefore is an…”
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Synthetic Small Molecules and Protein Secondary Structure Mimetics as Modulators of Hypoxia-Inducible Transcription and Integrin Receptors Function by Kushal, Swati

“…Transcription factors are the key regulators of cancer gene expression and play a critical role in every aspect of tumorigenesis. Despite their relevance in…”
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Correction to Inhibition of Hypoxia Inducible Factor 1–Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix by Henchey, Laura K, Kushal, Swati, Dubey, Ramin, Chapman, Ross N, Olenyuk, Bogdan Z, Arora, Paramjit S

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Inhibition of hypoxia-inducible transcription factor complex with designed epipolythiodiketopiperazine by Kushal, Swati, Wang, Hui, László, Csaba F., Szábo, Lajos Z., Olenyuk, Bogdan Z.

“…Designed small molecule inhibitors of hypoxia‐inducible gene expression have potential to become new research tools for molecular biology, genetics and serve…”
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