Search Results - "Kuschak, T"

c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene by KUSCHAK, T. I, KUSCHAK, B. C, TAYLOR, C. L, WRIGHT, J. A, WIENER, F, MAI, S

“…The mechanisms through which the oncoprotein c-Myc initiates locus-specific gene amplification are not understood. When analysing the initiation mechanism of…”
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Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II by Hasinoff, Brian B., Kuschak, Theodore I., Creighton, Andrew M., Fattman, Cheryl L., Allan, William P., Thampatty, Padmakumari, Yalowich, Jack C.

“…A Chinese hamster ovary (CHO) cell line highly resistant to the non-cleavable complex-forming topoisomerase II inhibitor dexrazoxane (ICRF-187, Zinecard ®) was…”
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Isolation of extrachromosomal elements by histone immunoprecipitation by Kuschak, T I, Kuschak, B C, Smith, G M, Wright, J A, Mai, S

“…Here, we describe a gentle and effective method for the rapid and reproducible isolation of histone-bound extrachromosomal DNA molecules called…”
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A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane) by Hasinoff, Brian B., Kuschak, Theodore I., Yalowich, Jack C., Creighton, Andrew M.

“…A series of twelve structurally related bisdioxopiperazines that included ICRF-187 (dexrazoxane), ICRF-159 (razoxane), ICRF-193, and ICRF-154 were examined…”
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c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene by Kuschak, TI, Kuschak, B C, Taylor, CL, Wright, JA, Wiener, F, Mai, S

“…The mechanisms through which the oncoprotein c-Myc initiates locus-specific gene amplification are not understood. When analysing the initiation mechanism of…”
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Metabolism of the cardioprotective agents dexrazoxane (ICRF-187) and levrazoxane (ICRF-186) by the isolated hepatocyte by Hasinoff, B B, Venkataram, S, Singh, M, Kuschak, T I

“…1. The metabolism of dexrazoxane (ICRF-187) and its optical isomer levrazoxane (ICRF-186) by the isolated rat hepatocyte was studied by hplc. 2…”
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Myc-induced cyclin D2 genomic instability in murine B cell neoplasms by Mushinski, J F, Hanley-Hyde, J, Rainey, G J, Kuschak, T I, Taylor, C, Fluri, M, Stevens, L M, Henderson, D W, Mai, S

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Deregulated Expression of c-Myc in a Translocation-Negative Plasmacytoma on Extrachromosomal Elements That Carry IgH and Myc Genes by Wiener, Francis, Kuschak, Theodore I., Ohno, Shinsuke, Mai, Sabine

“…The induced expression of c-Myc in plasmacytomas in BALB/c mice is regularly associated with nonrandom chromosomal translocations that juxtapose the c-myc gene…”
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Chromosomal and Extrachromosomal Instability of the cyclin D2 Gene is Induced by Myc Overexpression by Mai, Sabine, Hanley-Hyde, Joan, Rainey, G. Jonah, Kuschak, Theodore I., Paul, James T., Littlewood, Trevor D., Mischak, Harald, Stevens, Lisa M., Henderson, Darren W., Mushinski, J. Frederic

“…We examined the expression of cyclins D1, D2, D3, and E in mouse B-lymphocytic tumors. Cyclin D2 mRNA was consistently elevated in plasmacytomas, which…”
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The ribonucleotide reductase R2 gene is a non-transcribed target of c-Myc-induced genomic instability by Kuschak, Theodore I., Taylor, Cheryl, McMillan-Ward, Eileen, Israels, Sara, Henderson, Darren W., Mushinski, J.Frederic, Wright, Jim A., Mai, Sabine

“…The c-Myc oncoprotein is highly expressed in malignant cells of many cell types, but the mechanism by which it contributes to the transformation process is not…”
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The one-ring open hydrolysis intermediates of the cardioprotective agent dexrazoxane (ICRF-187) do not inhibit the growth of Chinese hamster ovary cells or the catalytic activity of DNA topoisomerase II by Hasinoff, B B, Kuschak, T I, Fattman, C L, Yalowich, J C

“…Dexrazoxane (ICRF-187), which is clinically used to reduce doxorubicin-induced cardiotoxicity, has growth inhibitory properties through its ability to inhibit…”
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Household transmission of SARS, 2003 by Wilson-Clark, Samantha D, Deeks, Shelley L, Gournis, Effie, Hay, Karen, Bondy, Susan, Kennedy, Erin, Johnson, Ian, Rea, Elizabeth, Kuschak, Theodore, Green, Diane, Abbas, Zahid, Guarda, Brenda

“…In the 2003 outbreak in Toronto (in Ontario, Canada) of severe acute respiratory syndrome (SARS), about 20% of cases resulted from household transmission. The…”
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Update: Novel Influenza A (H1N1) Virus Infection — Mexico, March–May, 2009 by Cordova, J.A, Hernandez, M, Lopez-Gatell, H, Bojorquez, I, Palacios, E, Rodriguez, G, de la Rosa, B, Ocampo, R, Alpuche, C, Flores, R, Hernandez, J.E, Tustin, J, Watkins, K, Stuart, T.L, Kuschak, T, Stroher, U, Soule, G, Balcewich, B, Azziz-Baumgartner, E, Lafond, K, Mott, J, Mahoney, F, Uyeki, T, McCarron, M, Mounts, A, Widdowson, M.A, Xu, X, Shu, B, Lindstrom, S, Klimov, A, Katz, J, Winchell, J, Etienne, K, Waterman, S, McAuliffe, J, Dowell, S, Chavez, P.R

“…On April 12, 2009, Mexico responded to a request for verification by the World Health Organization (WHO) of an outbreak of acute respiratory illness in the…”
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c-Myc initiates illegitimate replication of the ribonucleotide reductase R2gene by Kuschak, T I, Kuschak, B C, Taylor, C L, Wright, J A, Wiener, F, Mai, S

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A cis-trans interaction at the 3'-untranslated region of ribonucleotide reductase mRNA is regulated by TGF-beta 1, TGF-beta 2, and TGF-beta 3 by Amara, F M, Smith, G M, Kuschak, T I, Takeuchi, T L, Wright, J A

“…The R2 component of ribonucleotide reductase is rate-limiting for DNA synthesis in proliferating cells, and recently, it has been shown that aberrant…”
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Transforming growth factor-beta1 stimulates multiple protein interactions at a unique cis-element in the 3'-untranslated region of the hyaluronan receptor RHAMM mRNA by Amara, F M, Entwistle, J, Kuschak, T I, Turley, E A, Wright, J A

“…The receptor for hyaluronan mediated motility (RHAMM) gene expression is markedly elevated in fibrosarcomas exposed to transforming growth factor-beta1…”
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A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitor effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane) by HASINOFF, B. B, KUSCHAK, T. I, YALOWICH, J. C, CREIGHTON, A. M

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Defects in base excision repair combined with elevated intracellular dCTP levels dramatically reduce mutation induction in yeast by ethyl methanesulfonate and N-methyl-N′-nitro-N-nitrosoguanidine by Kunz, Bernard A., Henson, Elizabeth S., Karthikeyan, Ramachandran, Kuschak, Theodore, McQueen, Shelley A., Scott, Catherine A., Xiao, Wei

“…Previously, we determined that elimination of deoxycytidylate (dCMP) deaminase (DCD1) in the yeast Saccharomyces cerevisiae increases the intracellular…”
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Update: Novel Influenza A (H1N1) Virus Infection - Mexico, March-May, 2009 by Cordova, J A, Hernandez, M, Lopez-Gatell, H, Bojorquez, I, Palacios, E, Rodriguez, G, de la Rosa, B, Ocampo, R, Alpuche, C, Flores, R, Hernandez, J E, Tustin, J, Watkins, K, Stuart, T L, Kuschak, T, Ströher, U, Soule, G, Balcewich, B, Azziz-Baumgartner, E, Lafond, K, Mott, J, Mahoney, F, Uyeki, T, McCarron, M, Mounts, A, Widdowson, M A, Xu, X, Shu, B, Lindstrom, S, Klimov, A, Katz, J, Winchell, J, Penaranda, S, Dybdahl-Sissoko, N, Ching, K, Warner, A, Etienne, K, Waterman, S, McAuliffe, J, Dowell, S, Chavez, P R

“…On Apr 12, 2009, Mexico responded to a request for verification by the World Health Organization of an outbreak of acute respiratory illness in the small…”
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Transforming growth factor- beta sub(1) stimulates multiple protein interactions at a unique cis-element in the 3'-untranslated region of the hyaluronan receptor RHAMM mRNA by Amara, F M, Entwistle, J, Kuschak, TI, Turley, E A, Wright, JA

“…The receptor for hyaluronan mediated motility (RHAMM) gene expression is markedly elevated in fibrosarcomas exposed to transforming growth factor- beta sub(1)…”
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