Search Results - "Kusch, Angelika"

Intrinsic Deregulation of Vascular Smooth Muscle and Myofibroblast Differentiation in Mesenchymal Stromal Cells from Patients with Systemic Sclerosis by Hegner, Björn, Schaub, Theres, Catar, Rusan, Kusch, Angelika, Wagner, Philine, Essin, Kirill, Lange, Claudia, Riemekasten, Gabriela, Dragun, Duska

“…Obliterative vasculopathy and fibrosis are hallmarks of systemic sclerosis (SSc), a severe systemic autoimmune disease. Bone marrow-derived mesenchymal stromal…”
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Autoantibodies Targeting AT1- and ETA-Receptors Link Endothelial Proliferation and Coagulation via Ets-1 Transcription Factor by Catar, Rusan, Herse-Naether, Melanie, Zhu, Nan, Wagner, Philine, Wischnewski, Oskar, Kusch, Angelika, Kamhieh-Milz, Julian, Eisenreich, Andreas, Rauch, Ursula, Hegner, Björn, Heidecke, Harald, Kill, Angela, Riemekasten, Gabriela, Kleinau, Gunnar, Scheerer, Patrick, Dragun, Duska, Philippe, Aurelie

“…Scleroderma renal crisis (SRC) is an acute life-threatening manifestation of systemic sclerosis (SSc) caused by obliterative vasculopathy and thrombotic…”
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Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin by Al-Diab, Ola, Sünkel, Christin, Blanc, Eric, Catar, Rusan Ali, Ashraf, Muhammad Imtiaz, Zhao, Hongfan, Wang, Pinchao, Rinschen, Markus M, Fritsche-Guenther, Raphaela, Grahammer, Florian, Bachmann, Sebastian, Beule, Dieter, Kirwan, Jennifer A, Rajewsky, Nikolaus, Huber, Tobias B, Gürgen, Dennis, Kusch, Angelika

“…Sex differences exist in the prevalence and progression of major glomerular diseases. Podocytes are the essential cell-type in the kidney which maintain the…”
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Sex-Specific mTOR Signaling Determines Sexual Dimorphism in Myocardial Adaptation in Normotensive DOCA-Salt Model by Gürgen, Dennis, Kusch, Angelika, Klewitz, Robin, Hoff, Uwe, Catar, Rusan, Hegner, Björn, Kintscher, Ulrich, Luft, Friedrich C, Dragun, Duska

“…The deoxycorticosterone acetate (DOCA)-salt mouse model exhibits adverse cardiac remodeling in male mice and cardiac protection in female mice, even when blood…”
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17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling by Kusch, Angelika, Schmidt, Maria, Gürgen, Dennis, Postpieszala, Daniel, Catar, Rusan, Hegner, Björn, Davidson, Merci M, Mahmoodzadeh, Shokoufeh, Dragun, Duska

“…Adaptive cardiac remodeling is characterized by enhanced signaling of mTORC2 downstream kinase Akt. In females, 17ß-estradiol (E2), as well as Akt contribute…”
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mTOR Regulates Vascular Smooth Muscle Cell Differentiation From Human Bone Marrow–Derived Mesenchymal Progenitors by Hegner, Björn, Lange, Maria, Kusch, Angelika, Essin, Kirill, Sezer, Orhan, Schulze-Lohoff, Eckhard, Luft, Friedrich C, Gollasch, Maik, Dragun, Duska

“…OBJECTIVE—Vascular smooth muscle cells (VSMCs) and circulating mesenchymal progenitor cells (MSCs) with a VSMC phenotype contribute to neointima formation and…”
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The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13 by Gräler, Markus H., Grosse, Robert, Kusch, Angelika, Kremmer, Elisabeth, Gudermann, Thomas, Lipp, Martin

“…Sphingosine 1‐phosphate (S1P) receptors represent a novel subfamily of G‐protein‐coupled receptors binding S1P specifically and with high affinity. Although…”
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Stat1 nuclear translocation by nucleolin upon monocyte differentiation by Jerke, Uwe, Tkachuk, Sergey, Kiyan, Julia, Stepanova, Victoria, Kusch, Angelika, Hinz, Michael, Dietz, Rainer, Haller, Hermann, Fuhrman, Bianca, Dumler, Inna

“…Members of the signal transducer and activator of transcription (Stat) family of transcription factors traverse the nuclear membrane through a specialized…”
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The tight junction protein ZO-2 mediates proliferation of vascular smooth muscle cells via regulation of Stat1 by Kusch, Angelika, Tkachuk, Sergey, Tkachuk, Natalia, Patecki, Margret, Park, Joon-Keun, Dietz, Rainer, Haller, Hermann, Dumler, Inna

“…Aims Recent evidence suggests that the zonula occludens protein 2 (ZO-2) might have additional cellular functions, beyond regulation of paracellular…”
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Urokinase Stimulates Human Vascular Smooth Muscle Cell Migration via a Phosphatidylinositol 3-Kinase-Tyk2 Interaction by Kusch, Angelika, Tkachuk, Sergey, Haller, Hermann, Dietz, Rainer, Gulba, Dietrich C., Lipp, Martin, Dumler, Inna

“…Janus kinases Jak1 and Tyk2 play an important role in urokinase-type plasminogen activator (uPA)-dependent signaling. We have recently demonstrated that both…”
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Non-HLA antibodies targeting angiotensin II Type 1 receptor and endothelin-1 Type A receptors induce endothelial injury via β2-arrestin link to mTOR pathway by Catar, Rusan Ali, Wischnewski, Oskar, Chen, Lei, Heidecke, Harald, Rutz, Claudia, Schülein, Ralf, Dragun, Duska, Philippe, Aurélie, Kusch, Angelika

“…Functional non-HLA antibodies (antibodies to non-human leukocyte antigens) targeting the G protein-coupled receptors angiotensin II type 1 receptor (AT1R) and…”
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Molecular and Cellular Mechanisms of Lipocalin-2-Mediated Renopro-tection in Kidney Transplantation: TH-OR55 by Pfefferkorn, Anna M., Zhao, Liang, Xu, Minze, Kusch, Angelika, Fritsche, Raphaela, Erdogan, Cem, Schwelberger, Hubert G., Aigner, Felix, Patzak, Andreas, Sauer, Igor M., Ashraf, Muhammad Imtiaz

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Sex differences in exercise-induced physiological myocardial hypertrophy are modulated by oestrogen receptor beta by Dworatzek, Elke, Mahmoodzadeh, Shokoufeh, Schubert, Carola, Westphal, Christina, Leber, Joachim, Kusch, Angelika, Kararigas, Georgios, Fliegner, Daniela, Moulin, Maryline, Ventura-Clapier, Renée, Gustafsson, Jan-Ake, Davidson, Mercy M, Dragun, Duska, Regitz-Zagrosek, Vera

“…Oestrogen receptor alpha (ERα) and beta (ERβ) are involved in the regulation of pathological myocardial hypertrophy (MH). We hypothesize that both ER are also…”
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Non-HLA-antibodies targeting Angiotensin type 1 receptor and antibody mediated rejection by Dragun, Duska, Catar, Rusan, Kusch, Angelika, Heidecke, Harald, Philippe, Aurélie

“…Abstract Antibody-mediated mechanisms directed against non-HLA related targets may exert negative impact on allograft function and survival. Angiotensin type 1…”
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Sex-specific dimorphism in cellular stress response upon mTOR inhibition revealed by podocyte specific RNA sequencing by Guergen, Dennis, Kusch, Angelika, Stottmeister, Christin, Al-Diab, Ola, Grahammer, Florian, Huber, Tobias B, Rajewski, Nikolaus, Dragun, Duska

“…Why some kidney transplant patients treated with mTOR inhibitors develop proteinuria and majority of recipients of other solid organs improve their kidney…”
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Linking proteolysis to lipids by Kusch, Angelika

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Real-time monitoring of hypertrophy in HL-1 cardiomyocytes by impedance measurements reveals different modes of growth by Bloch, Laura, Ndongson-Dongmo, Bernadin, Kusch, Angelika, Dragun, Duska, Heller, Regine, Huber, Otmar

“…Hypertrophic growth is a response of the heart to increased mechanical load or physiological stress. Thereby, cardiomyocytes grow in length and/or width to…”
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17β-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling by Kusch, Angelika, Schmidt, Maria, Gürgen, Dennis, Postpieszala, Daniel, Rusan Catar, Hegner, Björn, Davidson, Merci M, Mahmoodzadeh, Shokoufeh, Dragun, Duska

“…Adaptive cardiac remodeling is characterized by enhanced signaling of mTORC2 downstream kinase Akt. In females, 17β-estradiol (E2), as well as Akt contribute…”
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Abstract 442: Cardiomyocyte Specific mTORC1 Deletion Precipitates Interstitial Fibrosis, Heart Failure And Loss Of Female Cardio Protection by Guergen, Dennis, Kusch, Angelika, Kauz, Nelli, Catar, Rusan A, Brink, Marijke, Dragun, Duska

“…Abstract only Mechanistic target of rapamycin (mTOR) kinase operates in two functionally and structurally distinct multiprotein complexes mTORC1 and mTORC2…”
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Abstract 270: mTORC1 is Essential for Cardiomyocyte Homeostasis and Female Sex Related Cardioprotection by Guergen, Dennis B, Beiner, Nelli, Catar, Rusan, Mielke, Thorsten, Busch, Hauke, Boerries, Melanie, Dengjel, Joern, Brink, Marijke, Grahammer, Florian, Huber, Tobias B, Kusch, Angelika, Dragun, Duska

“…Abstract only Mechanistic target of rapamycin (mTOR) kinase operates in two functionally and structurally distinct protein complexes mTORC1 and mTORC2. Raptor…”
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