Search Results - "Kusakabe, Tetsuya"

The Roadmap to Approval under Japan’s Two-Track Regulatory System: Comparing Six Regenerative Medical Products by Matsushita, Shunsuke, Tachibana, Keisuke, Kusakabe, Tetsuya, Hirayama, Ryuichi, Tsutsumi, Yasuo, Kondoh, Masuo

“…The Japanese conditional and time-limited (CTL) approval framework, a tiered system for regenerative medical products, was initiated in 2014. Here, we compare…”
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New Japanese Regulatory Frameworks for Post-Marketing Management of Pharmaceutical Products by Takamura, Kento, Tachibana, Keisuke, Kusakabe, Tetsuya, Nakai, Kiyohito, Tsutsumi, Yasuo, Kondoh, Masuo

“…Dossiers on approved pharmaceutical products must be kept updated and current during the products’ life cycles. The coalition, merger and acquisition along…”
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Effects of a revised rate- and state-dependent friction law on aftershock triggering model by Kame, Nobuki, Fujita, Satoshi, Nakatani, Masao, Kusakabe, Tetsuya

“…Seismicity may be considered as a sequence of earthquake nucleation events controlled by regional loading history. On the basis of this concept, Dieterich…”
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Overview of the Premarketing and Postmarketing Requirements for Drugs Granted Japanese Conditional Marketing Approval by Matsushita, Shunsuke, Tachibana, Keisuke, Kusakabe, Tetsuya, Hirayama, Ryuichi, Tsutsumi, Yasuo, Kondoh, Masuo

“…For drugs that are intended to fill unmet medical needs, such as the treatment of rare diseases or a subtype of cancer, it can take a long time to conduct…”
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A Concept for a Japanese Regulatory Framework for Emerging Medical Devices with Frequently Modified Behavior by Ota, Nagomi, Tachibana, Keisuke, Kusakabe, Tetsuya, Sanada, Shoji, Kondoh, Masuo

“…Recent progress in the Internet of Things and artificial intelligence has made it possible to utilize the vast quantity of personal health records, clinical…”
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Feasibility of acoustic monitoring of strength drop precursory to earthquake occurrence by Kame, Nobuki, Nagata, Kohei, Nakatani, Masao, Kusakabe, Tetsuya

“…Rate- and state-dependent friction law (RSF), proposed on the basis of laboratory experiments, has been extensively applied to modeling of earthquake…”
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Seismic moment and volume change of a spherical source by Kumagai, Hiroyuki, Maeda, Yuta, Ichihara, Mie, Kame, Nobuki, Kusakabe, Tetsuya

“…A spherical source, one of the simplest seismic sources, has been represented in various ways in the literature. These representations include a spherical…”
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Regulatory perspectives of Japan by Kusakabe, Tetsuya

“…In this article, the 2013 regenerative medicine laws and regulations in Japan are addressed. The Regenerative Medicine Promotion Law was promulgated in May…”
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Derivation of 2-D XBIEM kernels and their application to a rupture crossing a bimaterial interface by Kusakabe, Tetsuya, Kame, Nobuki

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A Different Case of Penumbra: A Japanese Framework for Safe and Expedited Access to High-risk Medical Devices by Yamamoto, Haruko, Kusakabe, Tetsuya, Takahashi, Mimei

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A doxycycline-inducible CYP3A4-Caco-2 cell line as a model for evaluating safety of aflatoxin B1 in the human intestine by Bai, Lin, Tachibana, Keisuke, Murata, Michika, Inoue, Tetsunori, Mizuguchi, Hiroyuki, Maeda, Shinichiro, Ikemura, Kenji, Okuda, Masahiro, Kusakabe, Tetsuya, Kondoh, Masuo

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Earthquake cycle simulation with a revised rate- and state-dependent friction law by Kame, Nobuki, Fujita, Satoshi, Nakatani, Masao, Kusakabe, Tetsuya

“…Rate- and state-dependent friction law (RSF) has been recently revised by Nagata et al. (2012); the value of direct effect parameter has been revised to be…”
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On volume-source representations based on the representation theorem by Ichihara, Mie, Kusakabe, Tetsuya, Kame, Nobuki, Kumagai, Hiroyuki

“…We discuss different ways to characterize a moment tensor associated with an actual volume change of ΔV C , which has been represented in terms of either the…”
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Earthquake Nucleation on Faults with a Revised Rate- and State-Dependent Friction Law by Kame, Nobuki, Fujita, Satoshi, Nakatani, Masao, Kusakabe, Tetsuya

“…Recently N agata et al . (J Geophys Res 117:B02314, 2012 ) have proposed a new version of rate- and state-dependent friction law (RSF) that seems to have…”
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Sequence Preference for Strand Cleavage of Gapped Duplexes by Dynemicin A: Possible Mechanism of Sequence-Dependent Double-Stranded Breaks by Kusakabe, Tetsuya, Uesugi, Motonari, Sugiura, Yukio

“…A double-stranded DNA cleavage mechanism by a novel enediyne type antitumor antibiotic, dynemicin A, has been investigated through sequence-dependent strand…”
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Conformation-selective DNA strand breaks by dynemicin: A molecular wedge into flexible regions of DNA by Kusakabe, Tetsuya, Maekawa, Kojiro, Ichikawa, Atsushi, Uesugi, Motonari, Sugiura, Yukio

“…We present evidence that the enediyne antitumor antibiotic dynemicin recognizes and cleaves conformationally flexible regions of DNA. This is based on specific…”
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Synthesis and DNA binding properties of amide bond-modified analogues related to distamycin by Yamamoto, Yasuo, Kimachi, Tetsutaro, Kanaoka, Yoshitomo, Kato, Satoshi, Bessho, Kiyoshi, Matsumoto, Takuyuki, Kusakabe, Tetsuya, Sugiura, Yukio

“…Novel nitro analogues of distamycin which have trans olefin or α-diketo moiety instead of amide bond were synthesized. Their DNA binding properties studied by…”
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A new synthetic analogue of the bracken ultimate carcinogen: Elevation of stability and alteration of DNA alkylation site selectivity by Kigoshi, Hideo, Kitamura, Yuusi, Fujita, Tatsuya, Ohashi, Hidekazu, Atsumi, Toshiyuki, Takagi, Junko, Mutou, Tsuyoshi, Yamada, Kiyoyuki, Kusakabe, Tetsuya, Sasaki, Daisuke, Sugiura, Yukio

“…The benzodienone 4 as a stable analogue of the bracken ultimate carcinogen ( 2) has been designed and synthesized. In the reaction with DNA the compound 4 was…”
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DNA binding and cleavage of a novel antitumor antibiotic dynemicin A: detection of binding and cleavage sites by exonuclease III digestion and alkali-induced cutting reactions by Arakawa, T, Kusakabe, T, Kuwahara, J, Otsuka, M, Sugiura, Y

“…We found here that dynemicin A effectively breaks DNA strands under alkaline pH condition. Binding of dynemicin A to double-stranded DNA clearly interrupts the…”
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Hydrophobic DNA binding of esperamicin requires conformational distortion of the host DNA by Uesugi, Motonari, Kusakabe, Tetsuya, Sugiura, Yukio

“…Evidence is presented that the sequence-specific DNA binding of esperamicin is accompanied by structural distortion of the host DNA that depends on hydrophobic…”
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