Search Results - "Kus, Gokhan"

Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2 by Kus, Gokhan, Kabadere, Selda, Uyar, Ruhi, Kutlu, Hatice Mehtap

“…Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis…”
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Protective Effects of Lumbricus Extract on the Antioxidant System and Liver in an Experimentally Created Liver Ischemia Reperfusion Injury Model in Rats by Semih Oz, Yildiz, Fatma, Senturk, Hakan, Ustuner, Mehmet Cengiz, Donmez, Dilek Burukoglu, Kus, Gokhan, Ozbayer, Cansu, Kabay, Sahin, Cetin, Kismet Civi, Ozden, Hilmi

“…In this experimental study, we investigated the effects of Lumbricus extract on biochemical and histological markers of liver IR injury model in rats. A total…”
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Erythropoietin Protects the Kidney by Regulating the Effect of TNF-α in L-NAME-Induced Hypertensive Rats by Ozkurt, Mete, Uzuner, Kubilay, Erkasap, Nilufer, Kus, Gokhan, Ozyurt, Rumeysa, Uysal, Onur, Akyazi, Ibrahim, Kutlay, Ozden

“…Background/Aims: Hypertension is the leading cause of death worldwide. Chronic high blood pressure induces inflammation. Tumor necrosis factor (TNF)-α plays a…”
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The investigation of ceranib-2 on apoptosis and drug interaction with carboplatin in human non small cell lung cancer cells in vitro by Yildiz-Ozer, Merve, Oztopcu-Vatan, Pinar, Kus, Gokhan

“…Ceramide is found to be involved in inhibition of cell division and induction of apoptosis in certain tumour cells. Ceranib-2 is an agent that increases…”
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actions of leptin on survival and hydrogen peroxide toxicity in primary mixed glial cells of rat by Kabadere, Selda, Gokhan Kus, Ruhi Uyar, Pinar Oztopcu-Vatan, Nilufer Erkasap, Hulyam Kurt, Hasan Gunes

“…Studies indicate that leptin is involved in not only energy expenditure and food intake, but also in protection against apoptosis, in inflammation and in…”
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Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies by Sever, Belgin, Altıntop, Mehlika Dilek, Kuş, Gökhan, Özkurt, Mete, Özdemir, Ahmet, Kaplancıklı, Zafer Asım

“…In the current work, new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives (1–8) were synthesized via the ring closure reaction of 2-bromoacetophenone…”
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Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells by Vejselova, Djanan, Kutlu, Hatice Mehtap, Kuş, Gökhan

“…Acid ceramidases are enzymes with a vital role in metabolizing ceramide to sphingosine-1-phosphate that is an antiproliferative metabolite in the ceramide…”
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Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis by Kabadere, Selda, Kus, Gokhan, Uyar, Ruhi, Oztopcu-Vatan, Pinar

“…Abstract Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce…”
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Modulation of Corpus Striatal Neurochemistry by Astrocytes and Vasoactive Intestinal Peptide (VIP) in Parkinsonian Rats by Yelkenli, İbrahim Halil, Ulupinar, Emel, Korkmaz, Orhan Tansel, Şener, Erol, Kuş, Gökhan, Filiz, Zeynep, Tunçel, Neşe

“…The neurotoxin 6-hydroxydopamine (6-OHDA) is widely used in animal models of Parkinson’s disease. In various neurodegenerative diseases, astrocytes play…”
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Thrombelastographic evaluation of the influence of 2-RBC apheresis on donor’s coagulation system by Akay, Olga Meltem, Karagulle, Mustafa, Kus, Gokhan, Mutlu, Fezan Sahın, Gunduz, Eren

“…Abstract Rotation thrombelastogram (ROTEM®/TEG®) assays allow rapid global assessment of hemostatic function using whole blood. Since published data about the…”
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The effect of R547, a cyclin-dependent kinase inhibitor, on hepatocellular carcinoma cell death by Hacioğlu, Betül, Kuş, Gökhan, Kutlu, Hatice Mehtap, Kabadere, Selda

“…Hepatocellular carcinoma (HCC) is the third main cause of cancer-related death. Cyclin-dependent kinases (CDKs) and their cyclin partners regulate the cell…”
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The role of hemostatic mechanisms in the development of thrombosis in Behcet's disease: an analysis by modified rotation thromboelastogram (ROTEM) by Yaşar Bilge, N. Şule, Akay, O. Meltem, Kaşifoğlu, Timuçin, Kuş, Gökhan, Korkmaz, Cengiz

“…Behcet's disease (BD) is a multisystemic disorder characterised by recurrent oral and genital ulcers. Vasculitis and thrombotic events are the most important…”
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Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells by Kuş, Gökhan, Özkurt, Mete, Öztopcu Vatan, Pınar, Erkasap, Nilüfer, Uyar, Ruhi, Kabadere, Selda

“…Inhibiting ceramidase activity in cancer cells has been identified as a promising target for cancer therapy in recent studies. uhTs, we examined the possible…”
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Apium graveolens Extract Inhibits Cell Proliferation and Expression of Vascular Endothelial Growth Factor and Induces Apoptosis in the Human Prostatic Carcinoma Cell Line LNCaP by Köken, Tülay, Koca, Buğra, Özkurt, Mete, Erkasap, Nilüfer, Kuş, Gökhan, Karalar, Mustafa

“…Apium graveolens has been shown to inhibit the growth of a variety of cancer tissues. In this study, we investigated the anticancer effect of A. graveolens on…”
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Cytotoxic and apoptotic effects of ceranib-2 offering potential for a new antineoplastic agent in the treatment of cancer cells by VEJSELOVA, Djanan, KUTLU, Hatice Mehtap, KUŞ, Gökhan, KABADERE, Selda, UYAR, Ruhi

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The Evaluation of Hydroxyethyl Starch (6% HES 130/0.4) Solution's Potential Preventive Effects on Coagulation Status in Women with Gynecologic Malignancies Using Rotation Thromboelastography by Akay, Meltem Olga, Bilir, Ayten, Oge, Tufan, Kuş, Gökhan, Mutlu, Fezan Sahin

“…The aim of this study was to determine the effects of in vitro hemodilution with 6% hydroxyethyl starch (HES) 130/0.4 solution on the coagulation status of…”
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A 5-Fluorouracil Derivative: Carmofur as a New Potent Agent for Inhibition of Human Prostate and Breast Cancer Cell Lines by Kutlu, Hatice Mehtap, Sezer, Canan Vejselova, Kuş, Gökhan, Çömlekçi, Emre, İzgördü, Hüseyin

“…Breast and prostate cancers are frequent cancers worldwide. Their morbidity and mortality require to be diminished by developing new approaches and new potent…”
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Cytotoxic and apoptotic functions of licofelone on rat glioma cells by Kus, Gokhan, Oztopcu-Vatan, Pinar, Uyar, Ruhi, Kabadere, Selda

“…Gliomas are the largest group of central nervous system tumors and despite of clinical treatments death rate is very high. Inhibition of both cyclooxygenase…”
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The Evaluation of Hydroxyethyl Starch (6% HES 130/0.4) Solution's Potential Preventive Effects on Coagulation Status in Women with Gynecologic Malignancies Using Rotation Thromboelastography/Jinekolojik Maligniteli Kadinlarda Hidroksietil Nisasta (%6 HES 130/0.4) Solüsyonunun Potansiyel Koruyucu Etkilerinin Rotasyonel Trombelastografi Kullanilarak Degerlendirilmesi by Akay, Meltem Olga, Bilir, Ayten, Öge, Tufan, Kus, Gökhan, Mutlu, Fezan Sahin

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Investigation of proapoptotic and anticancer effects mediated by intracellular ceramide changing dependent on ARN14974=BOC treatment in human non-small cell lung cancer by Kuş, Gökhan, Sezer, Canan Vejselova, Yaylaci, Ömer Koray, Çömlekçi, Emre, Kutlu, Hatice Mehtap

“…Sphingolipids are structural molecules of cellular membranes, that regulate biological processes such growth, proliferation, migration, metastasis by…”
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