Search Results - "Kurz, Ken D."

Engineering the Proteolytic Specificity of Activated Protein C Improves Its Pharmacological Properties by Berg, David T., Gerlitz, Bruce, Shang, Jing, Smith, Tommy, Santa, Paula, Richardson, Mark A., Kurz, Ken D., Grinnell, Brian W., Mace, Ken, Jones, Bryan E.

“…Human activated protein C (APC) is an antithrombotic, antiinflammatory serine protease that plays a central role in vascular homeostasis, and activated…”
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Evidence that Blood Pressure Reduction by Serotonin Antagonists is Related to Alpha Receptor Blockade in Spontaneously Hypertensive Rats by COHEN, MARLENE L, FULLER, RAY W, KURZ, KEN D

“…In vitro affinity for vascular 5HT and alpha receptors was determined for several compounds (spiperone, ketanserin, mianserin, trazodone, mepiprazole,…”
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Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation by Cohen, M L, Kurz, K D

“…Pinacidil is a potent antihypertensive agent in animals and humans. In conscious spontaneously hypertensive rats after oral administration, pinacidil was…”
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Antithrombotic efficacy in the guinea pig of a derivative of human protein C with enhanced activation by thrombin by KURZ, K. D, SMITH, T, WILSON, A, GERLITZ, B, RICHARDSON, M. A, GRINNELL, B. W

“…Conversion by alpha-thrombin of the zymogen human protein C (HPC) to activated protein C (aPC) is an important physiologic feedback control mechanism for the…”
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Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67 by Fuller, R W, Kurz, K D, Mason, N R, Cohen, M L

“…Xylamidine and BW501C67 (alpha-anilino-N-2-m-chlorophenoxypropylacetamidine), serotonin antagonists that have been reported not to cross the blood-brain…”
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Effect of meta-chlorophenylpiperazine (mCPP), a central serotonin agonist and vascular serotonin receptor antagonist, on blood pressure in SHR by Cohen, M L, Kurz, K D, Fuller, R W

“…mCPP (meta-chlorophenylpiperazine) has agonist activity at some central serotonin receptors and antagonist activity at peripheral vascular 5HT2 receptors, both…”
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