Search Results - "Kurz, Emma"

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL by Aykut, Berk, Pushalkar, Smruti, Chen, Ruonan, Li, Qianhao, Abengozar, Raquel, Kim, Jacqueline I., Shadaloey, Sorin A., Wu, Dongling, Preiss, Pamela, Verma, Narendra, Guo, Yuqi, Saxena, Anjana, Vardhan, Mridula, Diskin, Brian, Wang, Wei, Leinwand, Joshua, Kurz, Emma, Kochen Rossi, Juan A., Hundeyin, Mautin, Zambrinis, Constantinos, Li, Xin, Saxena, Deepak, Miller, George

“…Bacterial dysbiosis accompanies carcinogenesis in malignancies such as colon and liver cancer, and has recently been implicated in the pathogenesis of…”
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The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression by Pushalkar, Smruti, Hundeyin, Mautin, Daley, Donnele, Zambirinis, Constantinos P, Kurz, Emma, Mishra, Ankita, Mohan, Navyatha, Aykut, Berk, Usyk, Mykhaylo, Torres, Luisana E, Werba, Gregor, Zhang, Kevin, Guo, Yuqi, Li, Qianhao, Akkad, Neha, Lall, Sarah, Wadowski, Benjamin, Gutierrez, Johana, Kochen Rossi, Juan Andres, Herzog, Jeremy W, Diskin, Brian, Torres-Hernandez, Alejandro, Leinwand, Josh, Wang, Wei, Taunk, Pardeep S, Savadkar, Shivraj, Janal, Malvin, Saxena, Anjana, Li, Xin, Cohen, Deirdre, Sartor, R Balfour, Saxena, Deepak, Miller, George

“…We found that the cancerous pancreas harbors a markedly more abundant microbiome compared with normal pancreas in both mice and humans, and select bacteria are…”
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EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion by Marzio, Antonio, Kurz, Emma, Sahni, Jennifer M., Di Feo, Giuseppe, Puccini, Joseph, Jiang, Shaowen, Hirsch, Carolina Alcantara, Arbini, Arnaldo A., Wu, Warren L., Pass, Harvey I., Bar-Sagi, Dafna, Papagiannakopoulos, Thales, Pagano, Michele

“…Non-small cell lung cancers (NSCLCs) harboring KEAP1 mutations are often resistant to immunotherapy. Here, we show that KEAP1 targets EMSY for…”
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Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy by Siolas, Despina, Vucic, Emily, Kurz, Emma, Hajdu, Cristina, Bar-Sagi, Dafna

“…Tumor genotype can influence the immune microenvironment, which plays a critical role in cancer development and therapy resistance. However, the immune effects…”
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Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer by Kurz, Emma, Hirsch, Carolina Alcantara, Dalton, Tanner, Shadaloey, Sorin Alberto, Khodadadi-Jamayran, Alireza, Miller, George, Pareek, Sumedha, Rajaei, Hajar, Mohindroo, Chirayu, Baydogan, Seyda, Ngo-Huang, An, Parker, Nathan, Katz, Matthew H.G., Petzel, Maria, Vucic, Emily, McAllister, Florencia, Schadler, Keri, Winograd, Rafael, Bar-Sagi, Dafna

“…Aerobic exercise is associated with decreased cancer incidence and cancer-associated mortality. However, little is known about the effects of exercise on…”
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PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer by Diskin, Brian, Adam, Salma, Cassini, Marcelo F., Sanchez, Gustavo, Liria, Miguel, Aykut, Berk, Buttar, Chandan, Li, Eric, Sundberg, Belen, Salas, Ruben D., Chen, Ruonan, Wang, Junjie, Kim, Mirhee, Farooq, Mohammad Saad, Nguy, Susanna, Fedele, Carmine, Tang, Kwan Ho, Chen, Ting, Wang, Wei, Hundeyin, Mautin, Rossi, Juan A. Kochen, Kurz, Emma, Haq, Muhammad Israr Ul, Karlen, Jason, Kruger, Emma, Sekendiz, Zennur, Wu, Dongling, Shadaloey, Sorin A. A., Baptiste, Gillian, Werba, Gregor, Selvaraj, Shanmugapriya, Loomis, Cynthia, Wong, Kwok-Kin, Leinwand, Joshua, Miller, George

“…Programmed cell death protein 1 (PD-1) ligation delimits immunogenic responses in T cells. However, the consequences of programmed cell death 1 ligand 1…”
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Innate αβ T-Cells Mediate Anti-Tumor Immunity by Orchestrating Immunogenic Macrophage Programming by Mishra, Ankita, Hundeyin, Mautin, Kurz, Emma, Miller, George

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Exploration of Mechanisms that Govern Tumorigenesis and Anti-tumor Immunity in Pancreatic Cancer by Kurz, Emma

“…This thesis work will approach the topic of pancreatic ductal adenocarcinoma (PDA) intractability in two distinct parts. The first chapter (Chapter 1; Pages…”
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Abstract LT005: Tumor-intrinsic gain of function p53R172H mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment that promotes resistance to immunotherapy by Siolas, Despina, Vucic, Emily, Kurz, Emma, Hajdu, Cristina, Bar-Sagi, Dafna

“…Abstract KRASG12D mutations in tumor cells can modify the immune microenvironment of pancreatic ductal adenocarcinoma (PDAC), though the effects of secondary…”
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RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer by Wang, Wei, Marinis, Jill M., Beal, Allison M., Savadkar, Shivraj, Wu, Yue, Khan, Mohammed, Taunk, Pardeep S., Wu, Nan, Su, Wenyu, Wu, Jingjing, Ahsan, Aarif, Kurz, Emma, Chen, Ting, Yaboh, Inedouye, Li, Fei, Gutierrez, Johana, Diskin, Brian, Hundeyin, Mautin, Reilly, Michael, Lich, John D., Harris, Philip A., Mahajan, Mukesh K., Thorpe, James H., Nassau, Pamela, Mosley, Julie E., Leinwand, Joshua, Kochen Rossi, Juan A., Mishra, Ankita, Aykut, Berk, Glacken, Michael, Ochi, Atsuo, Verma, Narendra, Kim, Jacqueline I., Vasudevaraja, Varshini, Adeegbe, Dennis, Almonte, Christina, Bagdatlioglu, Ece, Cohen, Deirdre J., Wong, Kwok-Kin, Bertin, John, Miller, George

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance and immunotherapeutic resistance. We discovered upregulation of…”
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Abstract PR-005: Tumor intrinsic p53 mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment promoting resistance to immunotherapy by Siolas, Despina, Vucic, Emily, Kurz, Emma, Hajdu, Cristina, Bar-Sagi, Dafna

“…Abstract Intratumoral genetic alterations can cause remodeling of local immune cell populations through distinct cellular mechanisms. After oncogenic KRAS,…”
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Systems‐Based Analysis of the Pancreatic Cancer‐Specific Glycome Reveals ST6GAL1 as a Driver of Human and Murine Disease by Chen, Shuhui, Kurz, Emma, Vucic, Emily, Baptiste, Gillian, Loomis, Cynthia, Hajdu, Cristina, Agarwal, Praveen, Bar Sagi, Dafna, Mahal, Lara

“…Pancreatic ductal adenocarcinoma (PDA) is the 3rd leading cause of cancer‐death in the U.S.. Glycans, such as CA‐19‐9, are biomarkers of PDA, but their roles…”
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Integrated Systems Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveals a Tumor-Promoting Role for ST6GAL1 by Kurz, Emma, Chen, Shuhui, Vucic, Emily, Baptiste, Gillian, Loomis, Cynthia, Agrawal, Praveen, Hajdu, Cristina, Bar-Sagi, Dafna, Mahal, Lara K.

“…Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. Glycans, such as carbohydrate antigen 19-9, are…”
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γδ T Cells Promote Steatohepatitis by Orchestrating Innate and Adaptive Immune Programming by Torres‐Hernandez, Alejandro, Wang, Wei, Nikiforov, Yuri, Tejada, Karla, Torres, Luisana, Kalabin, Aleksandr, Adam, Salma, Wu, Jingjing, Lu, Lu, Chen, Ruonan, Lemmer, Aaron, Camargo, Jimmy, Hundeyin, Mautin, Diskin, Brian, Aykut, Berk, Kurz, Emma, Kochen Rossi, Juan A., Khan, Mohammed, Liria, Miguel, Sanchez, Gustavo, Wu, Nan, Su, Wenyu, Adams, Steven, Haq, Muhammad Israr Ul, Farooq, Mohammad Saad, Vasudevaraja, Varshini, Leinwand, Joshua, Miller, George

“…Background and Aims The recruitment and activation of inflammatory cells in the liver delineates the transition from hepatic steatosis to steatohepatitis (SH)…”
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Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis by Moro, Loredana, Simoneschi, Daniele, Kurz, Emma, Arbini, Arnaldo A., Jang, Shaowen, Guaragnella, Nicoletta, Giannattasio, Sergio, Wang, Wei, Chen, Yu-An, Pires, Geoffrey, Dang, Andrew, Hernandez, Elizabeth, Kapur, Payal, Mishra, Ankita, Tsirigos, Aristotelis, Miller, George, Hsieh, Jer-Tsong, Pagano, Michele

“…Epigenetic plasticity is a pivotal factor that drives metastasis. Here, we show that the promoter of the gene that encodes the ubiquitin ligase subunit FBXL7…”
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Breast Density in a Contemporary Cohort of Women With Ductal Carcinoma In Situ (DCIS) by Gooch, Jessica C., Chun, Jennifer, Kaplowitz, Elianna, Kurz, Emma, Guth, Amber, Lee, Jiyon, Schnabel, Freya

“…Background Mammographic breast density (MBD) is an independent risk factor for breast cancer. Information regarding the relationship of MBD and breast cancer…”
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Targeting SYK signaling in myeloid cells protects against liver fibrosis and hepatocarcinogenesis by Torres-Hernandez, Alejandro, Wang, Wei, Nikiforov, Yuri, Tejada, Karla, Torres, Luisana, Kalabin, Aleksandr, Wu, Yue, Haq, Muhammad Israr Ul, Khan, Mohammed Y., Zhao, Zhen, Su, Wenyu, Camargo, Jimmy, Hundeyin, Mautin, Diskin, Brian, Adam, Salma, Rossi, Juan A. Kochen, Kurz, Emma, Aykut, Berk, Shadaloey, Sorin A. A., Leinwand, Joshua, Miller, George

“…Liver fibrosis and fibrosis-associated hepatocarcinogenesis are driven by chronic inflammation and are leading causes of morbidity and death worldwide. SYK…”
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RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer by Wang, Wei, Marinis, Jill M., Beal, Allison M., Savadkar, Shivraj, Wu, Yue, Khan, Mohammed, Taunk, Pardeep S., Wu, Nan, Su, Wenyu, Wu, Jingjing, Ahsan, Aarif, Kurz, Emma, Chen, Ting, Yaboh, Inedouye, Li, Fei, Gutierrez, Johana, Diskin, Brian, Hundeyin, Mautin, Reilly, Michael, Lich, John D., Harris, Philip A., Mahajan, Mukesh K., Thorpe, James H., Nassau, Pamela, Mosley, Julie E., Leinwand, Joshua, Kochen Rossi, Juan A., Mishra, Ankita, Aykut, Berk, Glacken, Michael, Ochi, Atsuo, Verma, Narendra, Kim, Jacqueline I., Vasudevaraja, Varshini, Adeegbe, Dennis, Almonte, Christina, Bagdatlioglu, Ece, Cohen, Deirdre J., Wong, Kwok-Kin, Bertin, John, Miller, George

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Abstract 6142: Gain-of-function p53R172H mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment promoting resistance to immunotherapy by Siolas, Despina, Vucic, Emily, Kurz, Emma, Hajdu, Cristina, Bar-Sagi, Dafna

“…Abstract The immune microenvironment plays a critical role in cancer development, progression and resistance to therapy. Specific tumor genotypes can…”
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Non-BRCA hereditary gene mutations and breast cancer phenotype: An ISC-RAM Consortia study by Arun, Banu, Schnabel, Freya Ruth, Chun, Jennifer, Heeke, Arielle Lutterman, Smith, Julia Anne, Roses, Daniel F., Kurz, Emma, Landry, Kara, Gutierrez Barrera, Angelica, Wood, Marie, Isaacs, Claudine

“…Abstract only…”
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