Search Results - "Kuruganti, Srilalitha"

Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine by Harris, Bethany D, Kuruganti, Srilalitha, Deshpande, Ashlesha, Goepfert, Paul A, Chatham, W Winn, Walter, Mark R

“…Background/objective Type-I interferons contribute to pathogenesis in systemic lupus erythematosus, including nephritis. Interferons consist of a family of 16…”
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The Drosophila gypsy insulator supports transvection in the presence of the vestigial enhancer by Schoborg, Todd, Kuruganti, Srilalitha, Rickels, Ryan, Labrador, Mariano

“…Though operationally defined as cis-regulatory elements, enhancers can also communicate with promoters on a separate homolog in trans, a mechanism that has…”
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Kinetic analysis of cytokine‐mediated receptor assembly using engineered FC heterodimers by Deshpande, Ashlesha, Putcha, Balananda‐Dhurjati Kumar, Kuruganti, Srilalitha, Walter, Mark R.

“…A method for analyzing ligand–receptor binding kinetics is described, which is based on an engineered FC domain (FChk) that forms a covalent heterodimer. To…”
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Influence of cytokine auto antibodies on serum IFNα activity in SLE (P6287) by Kuruganti, Srilalitha, Deshpande, Ashlesha, Chatham, Winn, Walter, Mark

“…Abstract The type-I interferon (IFN-I) family consists of 12 IFN-α subtypes as well as IFN-β and IFN-ω. IFN-α subtypes are thought to play a pivotal role in…”
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Production and characterization of thirteen human type-I interferon-α subtypes by Kuruganti, Srilalitha, Accavitti-Loper, Mary Ann, Walter, Mark R.

“…•Methods to produce 13 human IFNα subtypes have been established.•A monoclonal antibody that neutralizes IFNα16 bioactivity has been produced.•An assay to…”
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Epstein-Barr Virus IL-10 Engages IL-10R1 by a Two-step Mechanism Leading to Altered Signaling Properties by Yoon, Sung Il, Jones, Brandi C., Logsdon, Naomi J., Harris, Bethany D., Kuruganti, Srilalitha, Walter, Mark R.

“…Human interleukin-10 (hIL-10) is a pleiotropic cytokine that is able to suppress or activate cellular immune responses to protect the host from invading…”
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Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes by Kuruganti, Srilalitha, Miersch, Shane, Deshpande, Ashlesha, Speir, Jeffrey A., Harris, Bethany D., Schriewer, Jill M., Buller, R. Mark L., Sidhu, Sachdev S., Walter, Mark R.

“…Exogenous cytokine therapy can induce systemic toxicity, which might be prevented by activating endogenously produced cytokines in local cell niches. Here we…”
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High expression of Cyp6g1, a cytochrome P450 gene, does not necessarily confer DDT resistance in Drosophila melanogaster by Kuruganti, Srilalitha, Lam, Vita, Zhou, Xuguo, Bennett, Gary, Pittendrigh, Barry R., Ganguly, Ranjan

“…Cytochrome P450 monooxygenases, a family of detoxifying enzymes, are thought to confer resistance to various insecticides including DDT. Daborn et al. [Daborn,…”
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Changes in chromatin structure correlate with transcriptional activity of nucleolar rDNA in polytene chromosomes by Plata, Maria Piedad, Kang, Hyuck Joon, Zhang, Shaofei, Kuruganti, Srilalitha, Hsu, Shih-Jui, Labrador, Mariano

“…Ribosomal DNA genes (rDNA) are found in tandem arrays of hundreds of repeated genes, but only a fraction of these genes are actively transcribed. The…”
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Studies on cytochrome P450 genes in Drosophila melanogaster: Relationship between over expression and DDT resistance, and xenobiotic induction by Kuruganti, Srilalitha

“…Cytochrome P450 monooxygenases (CYPs), are involved in the metabolism of a diverse group of endogenous and xenobiotic compounds. In insects, CYPs are involved…”
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Studies on cytochrome P450 genes in Drosophila melanogaster: Relationship between over expression and DDT resistance, and xenobiotic induction by Kuruganti, Srilalitha

“…Cytochrome P450 monooxygenases (CYPs), are involved in the metabolism of a diverse group of endogenous and xenobiotic compounds. In insects, CYPs are involved…”
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