Search Results - "Kurtz, Myra B."

Sphingoid Base 1-phosphate Phosphatase: A Key Regulator of Sphingolipid Metabolism and Stress Response by Mandala, Suzanne M., Thornton, Rosemary, Tu, Zhenxing, Kurtz, Myra B., Nickels, Joseph, Broach, James, Menzeleev, Ramil, Spiegel, Sarah

“…The sphingolipid metabolites ceramide and sphingosine-1-phosphate are second messengers with opposing roles in mammalian cell growth arrest and survival; their…”
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Inactivation of Kex2p Diminishes the Virulence of Candida albicans by Newport, George, Kuo, Alan, Flattery, Amy, Gill, Charles, Blake, Julie J., Kurtz, Myra B., Abruzzo, George K., Agabian, Nina

“…Deletion of the kexin gene (KEX2) inCandida albicans has a pleiotropic effect on phenotype and virulence due partly to a defect in the expression of two major…”
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Novel Staphylococcus aureus Vaccine: Iron Surface Determinant B Induces Rapid Antibody Responses in Rhesus Macaques and Specific Increased Survival in a Murine S. aureus Sepsis Model by Kuklin, Nelly A, Clark, Desmond J, Secore, Susan, Cook, James, Cope, Leslie D, McNeely, Tessie, Noble, Liliane, Brown, Martha J, Zorman, Julie K, Wang, Xin Min, Pancari, Gregory, Fan, Hongxia, Isett, Kevin, Burgess, Bruce, Bryan, Janine, Brownlow, Michelle, George, Hugh, Meinz, Maria, Liddell, Mary E, Kelly, Rosemarie, Schultz, Loren, Montgomery, Donna, Onishi, Janet, Losada, Maria, Martin, Melissa, Ebert, Timothy, Tan, Charles Y, Schofield, Timothy L, Nagy, Eszter, Meineke, Andreas, Joyce, Joseph G, Kurtz, Myra B, Caulfield, Michael J, Jansen, Kathrin U, McClements, William, Anderson, Annaliesa S

“…Staphylococcus aureus is a major cause of nosocomial infections worldwide, and the rate of resistance to clinically relevant antibiotics, such as methicillin,…”
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Cell-based assays to detect inhibitors of fungal mRNA capping enzymes and characterization of sinefungin as a cap methyltransferase inhibitor by Chrebet, Gary L, Wisniewski, Douglas, Perkins, Ann L, Deng, Qiaolin, Kurtz, Myra B, Marcy, Alice, Parent, Stephen A

“…The m7GpppN cap at the 5' end of eukaryotic mRNAs is important for transcript stability and translation. Three enzymatic activities that generate the mRNA cap…”
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Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives by Bouffard, F. Aileen, Zambias, Robert A, Dropinski, James F, Balkovec, James M, Hammond, Milton L, Abruzzo, George K, Bartizal, Kenneth F, Marrinan, Jean A, Kurtz, Myra B

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Viridiofungins, novel inhibitors of sphingolipid synthesis by Mandala, S M, Thornton, R A, Frommer, B R, Dreikorn, S, Kurtz, M B

“…Viridiofungins are broad spectrum antifungal agents that inhibit the squalene synthase in vitro, but do not specifically inhibit fungal ergosterol synthesis in…”
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The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. Producing organism, fermentation, isolation, and biological activity by Mandala, S M, Thornton, R A, Frommer, B R, Curotto, J E, Rozdilsky, W, Kurtz, M B, Giacobbe, R A, Bills, G F, Cabello, M A, Martín, I

“…Potent antifungal activity was detected in fermentation extracts of Sporormiella australis and two related components were isolated from solid fermentations…”
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Molecular Cloning and Characterization of a Lipid Phosphohydrolase That Degrades Sphingosine-1-Phosphate and Induces Cell Death by Mandala, Suzanne M., Thornton, Rosemary, Galve-Roperh, Ismael, Poulton, Samantha, Peterson, Courtney, Olivera, Ana, Bergstrom, James, Kurtz, Myra B., Spiegel, Sarah

“…Sphingosine and sphingosine-1-phosphate (SPP) are interconvertible sphingolipid metabolites with opposing effects on cell growth and apoptosis. Based on…”
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Inhibition of fungal sphingolipid biosynthesis by rustmicin, galbonolide B and their new 21-hydroxy analogs by Harris, G H, Shafiee, A, Cabello, M A, Curotto, J E, Genilloud, O, Göklen, K E, Kurtz, M B, Rosenbach, M, Salmon, P M, Thornton, R A, Zink, D L, Mandala, S M

“…The mode of action of the known antifungal macrolides rustmicin (1) and galbonolide B (2) has been determined to be the inhibition of sphingolipid…”
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The Discovery of Enfumafungin, a Novel Antifungal Compound Produced by an Endophytic Hormonema Species Biological Activity and Taxonomy of the Producing Organisms by Peláez, Fernando, Cabello, Angeles, Platas, Gonzalo, Díez, María T., del Val, Antonio González, Basilio, Angela, Martán, Isabel, Vicente, Francisca, Bills, Gerald F., Giacobbe, Robert A, Schwartz, Robert E., Onishi, Janet C., Meinz, Maria S., Abruzzo, George K., Flattery, Amy M., Kong, Li, Kurtz, Myra B.

“…In a screening of natural products with antifungal activity derived from endophytic fungi, we detected a potent activity in a culture belonging to the…”
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Rustmicin, a Potent Antifungal Agent, Inhibits Sphingolipid Synthesis at Inositol Phosphoceramide Synthase by Mandala, Suzanne M., Thornton, Rosemary A., Milligan, James, Rosenbach, Mark, Garcia-Calvo, Margarita, Bull, Herbert G., Harris, Guy, Abruzzo, George K., Flattery, Amy M., Gill, Charles J., Bartizal, Kenneth, Dreikorn, Sarah, Kurtz, Myra B.

“…Rustmicin is a 14-membered macrolide previously identified as an inhibitor of plant pathogenic fungi by a mechanism that was not defined. We discovered that…”
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Khafrefungin, a Novel Inhibitor of Sphingolipid Synthesis by Mandala, Suzanne M., Thornton, Rosemary A., Rosenbach, Mark, Milligan, James, Garcia-Calvo, Margarita, Bull, Herbert G., Kurtz, Myra B.

“…In the course of screening for antifungal agents we have discovered a novel compound isolated from an endophytic fungus that inhibits fungal sphingolipid…”
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Purification of geranylgeranyltransferase I from Candida albicans and cloning of the CaRAM2 and CaCDC43 genes encoding its subunits by Mazur, Paul, Register, Elizabeth, Bonfiglio, Cynthia A, Yuan, Xiling, Kurtz, Myra B, Williamson, Joanne M, Kelly, Rosemarie

“…Department of Biochemistry, Merck Research Laboratories, RY80Y-200, PO Box 2000, Rahway, NJ 07065, USA ABSTRACT All previously characterized protein…”
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The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase by Douglas, C.M. (Merck Research Laboratories, Rahway, NJ.), Foor, F, Marrinan, J.A, Morin, N, Nielsen, J.B, Dahl, A.M, Mazur, P, Baginsky, W, Li, W, El-Sherbeini, M

“…In Saccharomyces cerevisiae, mutations in FKS1 confer hypersensitivity to the immunosuppressants FK506 and cyclosporin A, while mutations in ETG1 confer…”
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Arundifungin, a novel antifungal compound produced by fungi: biological activity and taxonomy of the producing organisms by Cabello, M A, Platas, G, Collado, J, Díez, M T, Martín, I, Vicente, F, Meinz, M, Onishi, J C, Douglas, C, Thompson, J, Kurtz, M B, Schwartz, R E, Bills, G F, Giacobbe, R A, Abruzzo, G K, Flattery, A M, Kong, L, Peláez, F

“…Echinocandins, the lipopeptide class of glucan synthase inhibitors, are an alternative to ergosterol-synthesis inhibitors to treat candidiasis and…”
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Inhibition of serine palmitoyl-transferase activity by lipoxamycin by Mandala, S M, Frommer, B R, Thornton, R A, Kurtz, M B, Young, N M, Cabello, M A, Genilloud, O, Liesch, J M, Smith, J L, Horn, W S

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Glucan synthase inhibitors as antifungal agents by Kurtz, Myra B., Rex, John H.

“…Fungal infections can range from superficial, noninvasive diseases of normal children and adults to life-threatening systemic diseases of immunocompromised…”
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Isolation of hem3 mutants from Candida albicans by sequential gene disruption by Kurtz, M B, Marrinan, J

“…Molecular methods for directed mutagenesis in Candida albicans have relied on a combination of gene disruption by transformation to inactivate one allele and…”
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Integrative Transformation of Candida albicans, Using a Cloned Candida ADE2 Gene by Kurtz, Myra B., Cortelyou, Mark W., Kirsch, Donald R.

“…Candida albicans is a diploid dimorphic yeast with no known sexual cycle. The development of a DNA transformation system would greatly improve the prospects…”
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One-step gene disruption by cotransformation to isolate double auxotrophs in Candida albicans by Kelly, R, Miller, S M, Kurtz, M B

“…The Candida albicans LEU2 gene was disrupted by substituting lambda DNA for a small deletion within the LEU2 gene. Cotransformation with a selectable URA3 ARS…”
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