Search Results - "Kurtz, Donald M."

Particle Swarm Fitting of Spin Hamiltonians: Magnetic Circular Dichroism of Reduced and NO-Bound Flavodiiron Protein by Transue, Wesley J., Snyder, Rae Ana, Caranto, Jonathan D., Kurtz, Donald M., Solomon, Edward I.

“…A particle swarm optimization (PSO) algorithm is described for the fitting of ground-state spin Hamiltonian parameters from variable-temperature/variable-field…”
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The Nitric Oxide Reductase Mechanism of a Flavo-Diiron Protein: Identification of Active-Site Intermediates and Products by Caranto, Jonathan D, Weitz, Andrew, Hendrich, Michael P, Kurtz, Donald M

“…The unique active site of flavo-diiron proteins (FDPs) consists of a nonheme diiron-carboxylate site proximal to a flavin mononucleotide (FMN) cofactor. FDPs…”
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Trojan Horse for Light-Triggered Bifurcated Production of Singlet Oxygen and Fenton-Reactive Iron within Cancer Cells by Cioloboc, Daniela, Kennedy, Christopher, Boice, Emily N, Clark, Emily R, Kurtz, Donald M

“…Traditional photodynamic therapy for cancer relies on dye-photosensitized generation of singlet oxygen. However, therapeutically effective singlet oxygen…”
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Structure of a Zinc Porphyrin-Substituted Bacterioferritin and Photophysical Properties of Iron Reduction by Benavides, Brenda S, Valandro, Silvano, Cioloboc, Daniela, Taylor, Alexander B, Schanze, Kirk S, Kurtz, Donald M

“…The iron storage protein bacterioferritin (Bfr) binds up to 12 hemes b at specific sites in its protein shell. The heme b can be substituted with the…”
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Targeted cancer cell delivery of arsenate as a reductively activated prodrug by Cioloboc, Daniela, Kurtz, Donald M.

“…Nanoformulations, prodrugs, and targeted therapies are among the most intensively investigated approaches to new cancer therapeutics. Human ferritin has been…”
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Active Site Metal Occupancy and Cyclic Di-GMP Phosphodiesterase Activity of Thermotoga maritima HD-GYP by Miner, Kyle D, Kurtz, Donald M

“…HD-GYPs make up a subclass of the metal-dependent HD phosphohydrolase superfamily and catalyze conversion of cyclic di­(3′,5′)-guanosine monophosphate…”
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A Diferrous-Dinitrosyl Intermediate in the N2O‑Generating Pathway of a Deflavinated Flavo-Diiron Protein by Caranto, Jonathan D, Weitz, Andrew, Giri, Nitai, Hendrich, Michael P, Kurtz, Donald M

“…Flavo-diiron proteins (FDPs) function as anaerobic nitric oxide scavengers in some microorganisms, catalyzing reduction of nitric to nitrous oxide. The FDP…”
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Photosensitized H2 generation from "one-pot" and "two-pot" assemblies of a zinc-porphyrin/platinum nanoparticle/protein scaffold by Clark, Emily R, Kurtz, Jr, Donald M

“…We report photosensitized H2 generation using a protein scaffold that nucleates formation of platinum nanoparticles (Pt NPs) and contains "built-in"…”
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Structural, Photophysical, and Photochemical Characterization of Zinc Protoporphyrin IX in a Dimeric Variant of an Iron Storage Protein: Insights into the Mechanism of Photosensitized H2 Generation by Benavides, Brenda S, Acharya, Rajendra, Clark, Emily R, Basak, Priyanka, Maroney, Michael J, Nocek, Judith M, Schanze, Kirk S, Kurtz, Donald M

“…Some of us have previously reported the preparation of a dimeric form of the iron storage protein, bacterioferritin (Bfr), in which the native heme b is…”
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Spectroscopy and DFT Calculations of a Flavo-diiron Enzyme Implicate New Diiron Site Structures by Weitz, Andrew C, Giri, Nitai, Caranto, Jonathan D, Kurtz, Donald M, Bominaar, Emile L, Hendrich, Michael P

“…Flavo-diiron proteins (FDPs) are non-heme iron containing enzymes that are widespread in anaerobic bacteria, archaea, and protozoa, serving as the terminal…”
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A Bacterial Hemerythrin Domain Regulates the Activity of a Vibrio cholerae Diguanylate Cyclase by Schaller, Ruth A, Ali, Syed Khalid, Klose, Karl E, Kurtz, Donald M

“…The first demonstrated example of a regulatory function for a bacterial hemerythrin (Bhr) domain is reported. Bhrs have a characteristic sequence motif…”
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Pathway for H2O2 and O2 detoxification in Clostridium acetobutylicum by Riebe, Oliver, Fischer, Ralf-Jorg, Wampler, David A, Kurtz, Donald M., Jr, Bahl, Hubert

“…1 Division of Microbiology, Institute of Biological Sciences, University of Rostock, Albert-Einstein-Str. 3, D-18051 Rostock, Germany 2 Department of…”
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Spectroscopy and DFT Calculations of Flavo–Diiron Nitric Oxide Reductase Identify Bridging Structures of NO-Coordinated Diiron Intermediates by Weitz, Andrew C, Giri, Nitai, Frederick, Rosanne E, Kurtz, Donald M, Bominaar, Emile L, Hendrich, Michael P

“…Flavo–diiron proteins (FDPs) are widespread in anaerobic bacteria, archaea, and protozoa, where they serve as the terminal components of dioxygen and nitric…”
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Crystal Structure, Exogenous Ligand Binding, and Redox Properties of an Engineered Diiron Active Site in a Bacterial Hemerythrin by Okamoto, Yasunori, Onoda, Akira, Sugimoto, Hiroshi, Takano, Yu, Hirota, Shun, Kurtz, Donald M, Shiro, Yoshitsugu, Hayashi, Takashi

“…A nonheme diiron active site in a 13 kDa hemerythrin-like domain of the bacterial chemotaxis protein DcrH-Hr contains an oxo bridge, two bridging carboxylate…”
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Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection by Mydel, Piotr, Takahashi, Yusuke, Yumoto, Hiromichi, Sztukowska, Maryta, Kubica, Malgorzata, Gibson, 3rd, Frank C, Kurtz, Jr, Donald M, Travis, Jim, Collins, L Vincent, Nguyen, Ky-Anh, Genco, Caroline Attardo, Potempa, Jan

“…The efficient clearance of microbes by neutrophils requires the concerted action of reactive oxygen species and microbicidal components within leukocyte…”
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Oxidative Protection of Hemoglobin and Hemerythrin by Cross-Linking with a Nonheme Iron Peroxidase: Potentially Improved Oxygen Carriers for Use in Blood Substitutes by Hathazi, Denisa, Mot, Augustin C, Vaida, Anetta, Scurtu, Florina, Lupan, Iulia, Fischer-Fodor, Eva, Damian, Grigore, Kurtz, Donald M, Silaghi-Dumitrescu, Radu

“…The nonheme peroxidase, rubrerythrin, shows the ability to reduce hydrogen peroxide to water without involving strongly oxidizing and free-radical-creating…”
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Vibrational Analysis of Mononitrosyl Complexes in Hemerythrin and Flavodiiron Proteins: Relevance to Detoxifying NO Reductase by Hayashi, Takahiro, Caranto, Jonathan D., Matsumura, Hirotoshi, Kurtz, Donald M., Moënne-Loccoz, Pierre

“…Flavodiiron proteins (FDPs) play important roles in the microbial nitrosative stress response in low-oxygen environments by reductively scavenging nitric oxide…”
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An HD-GYP Cyclic Di-Guanosine Monophosphate Phosphodiesterase with a Non-Heme Diiron–Carboxylate Active Site by Miner, Kyle D, Klose, Karl E, Kurtz, Donald M

“…The intracellular level of the ubiquitous bacterial secondary messenger, cyclic di-(3′,5′)-guanosine monophosphate (c-di-GMP), represents a balance between its…”
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Reductive dioxygen scavenging by flavo-diiron proteins of Clostridium acetobutylicum by Hillmann, Falk, Riebe, Oliver, Fischer, Ralf-Jörg, Mot, Augustin, Caranto, Jonathan D., Kurtz, Donald M., Bahl, Hubert

“…Two flavo-diiron proteins (FDPs), FprA1 and FprA2, are up-regulated when the strictly anaerobic solvent producer, Clostridium acetobutylicum, is exposed to…”
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CD/MCD/VTVH-MCD Studies of Escherichia coli Bacterioferritin Support a Binuclear Iron Cofactor Site by Kwak, Yeonju, Schwartz, Jennifer K, Huang, Victor W, Boice, Emily, Kurtz, Donald M, Solomon, Edward I

“…Ferritins and bacterioferritins (Bfrs) utilize a binuclear non-heme iron binding site to catalyze oxidation of Fe­(II), leading to formation of an iron mineral…”
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