Search Results - "Kurtovic, Sanela"

Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms by Jackson, Veronica, MD, Olsson, Therese, BMA, Kurtovic, Sanela, PhD, Folkersen, Lasse, MSc, Paloschi, Valentina, MSc, Wågsäter, Dick, PhD, Franco-Cereceda, Anders, MD, PhD, Eriksson, Per, PhD

“…Objective It is hypothesized that an altered turnover of extracellular matrix mediated by matrix metalloproteinases (MMPs) is present in thoracic aortic…”
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A Minimum Data Set for Sharing Biobank Samples, Information, and Data: MIABIS by Norlin, Loreana, Fransson, Martin N, Eriksson, Mikael, Merino-Martinez, Roxana, Anderberg, Maria, Kurtovic, Sanela, Litton, Jan-Eric

“…Numerous successful scientific results have emerged from projects using shared biobanked samples and data. In order to facilitate the discovery of…”
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Endogenous control genes in complex vascular tissue samples by Folkersen, Lasse, Kurtovic, Sanela, Razuvaev, Anton, Agardh, Hanna E, Gabrielsen, Anders, Paulsson-Berne, Gabrielle

“…Gene expression microarrays and real-time PCR are common methods used to measure mRNA levels. Each method has a fundamentally different approach of…”
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Functionally Diverging Molecular Quasi-Species Evolve by Crossing Two Enzymes by Emrén, Lars O., Kurtovic, Sanela, Runarsdottir, Arna, Larsson, Anna-Karin, Mannervik, Bengt

“…Molecular evolution is frequently portrayed by structural relationships, but delineation of separate functional species is more elusive. We have generated…”
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Identification of Emerging Quasi-Species in Directed Enzyme Evolution by Kurtovic, Sanela, Mannervik, Bengt

“…The bases of enzyme evolution are structural changes in protein scaffolds combined with recognition and propagation of novel variants with valuable functional…”
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Unraveling divergent gene expression profiles in bicuspid and tricuspid aortic valve patients with thoracic aortic dilatation: the ASAP study by Folkersen, Lasse, Wågsäter, Dick, Paloschi, Valentina, Jackson, Veronica, Petrini, Johan, Kurtovic, Sanela, Maleki, Shohreh, Eriksson, Maria J, Caidahl, Kenneth, Hamsten, Anders, Michel, Jean-Baptiste, Liska, Jan, Gabrielsen, Anders, Franco-Cereceda, Anders, Eriksson, Per

“…Thoracic aortic aneurysm (TAA) is a common complication in patients with a bicuspid aortic valve (BAV), the most frequent congenital heart disorder. For…”
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Colorimetric endpoint assay for enzyme-catalyzed iodide ion release for high-throughput screening in microtiter plates by Kurtovic, Sanela, Jansson, Ronnie, Mannervik, Bengt

“…Efforts are being made to engineer enzymes with enhanced activities against haloalkanes, a toxicologically important class of compounds widely used and…”
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Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase by Blikstad, Cecilia, Shokeer, Abeer, Kurtovic, Sanela, Mannervik, Bengt

“…Redesign of glutathione transferases (GSTs) has led to enzymes with remarkably enhanced catalytic properties. Exchange of substrate-binding residues in GST…”
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Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases by Kurtovic, Sanela, Shokeer, Abeer, Mannervik, Bengt

“…Six homologous Alpha class glutathione transferases of human, bovine, and rat origins were hybridized by means of DNA shuffling. The chimeric mutants were…”
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Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine by Kurtovic, Sanela, Grehn, Leif, Karlsson, Andreas, Hellman, Ulf, Mannervik, Bengt

“…Azathioprine is a prodrug that is widely used clinically as an immunosuppressive agent. The pharmacological action of azathioprine is associated with the…”
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Abstract 397: Analysis of Cell Phenotype in Relation to TGFβ Treatment of Aortic Smooth Muscle Cells and Myofibroblasts Isolated from Aortas and Valves of Thoracic Aortic Aneurysm Patients with a Tricuspid or a Bicuspid Valve by Paloschi, Valentina, Folkersen, Lasse, Kurtovic, Sanela, Wagsater, Dick, Franco Cereceda, Anders, Roy, Joy, Eriksson, Per

“…Abstract only Background Thoracic aortic aneurysm (TAA) is a pathological widening of the aorta, due to degeneration of extracellular matrix (ECM) and loss of…”
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Impaired Splicing of Fibronectin Is Associated With Thoracic Aortic Aneurysm Formation in Patients With Bicuspid Aortic Valve by Paloschi, Valentina, Kurtovic, Sanela, Folkersen, Lasse, Gomez, Delphine, Wågsäter, Dick, Roy, Joy, Petrini, Johan, Eriksson, Maria J, Caidahl, Kenneth, Hamsten, Anders, Liska, Jan, Michel, Jean-Baptiste, Franco-Cereceda, Anders, Eriksson, Per

“…OBJECTIVE—Thoracic aortic aneurysm is a common complication in patients with bicuspid aortic valve (BAV). Alternatively spliced extra domain A (EDA) of…”
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Diverging alternative splicing fingerprints in the transforming growth factor-β signaling pathway identified in thoracic aortic aneurysms by Kurtovic, Sanela, Paloschi, Valentina, Folkersen, Lasse, Gottfries, Johan, Franco-Cereceda, Anders, Eriksson, Per

“…Impaired regulation of the transforming growth factor-β (TGFβ) signaling pathway has been linked to thoracic aortic aneurysm (TAA). Previous work has indicated…”
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Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality by Mannervik, Bengt, Runarsdottir, Arna, Kurtovic, Sanela

“…A functional enzyme displays activity with at least one substrate and can be represented by a vector in substrate-activity space. Many enzymes, including GSTs…”
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Structural Determinants of Glutathione Transferases with Azathioprine Activity Identified by DNA Shuffling of Alpha Class Members by Kurtovic, Sanela, Modén, Olof, Shokeer, Abeer, Mannervik, Bengt

“…A library of alpha class glutathione transferases (GSTs), composed of chimeric enzymes derived from human (A1-1, A2-2 and A3-3), bovine (A1-1) and rat (A2-2…”
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Emergence of Novel Enzyme Quasi-Species Depends on the Substrate Matrix by Kurtovic, Sanela, Shokeer, Abeer, Mannervik, Bengt

“…Current research on enzyme evolution has shown that many enzymes are promiscuous and have activities with alternative substrates. Mutagenesis tends to relax…”
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Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library by Kurtovic, Sanela, Runarsdottir, Arna, Emrén, Lars O., Larsson, Anna-Karin, Mannervik, Bengt

“…A library of recombinant glutathione transferases (GSTs) generated by shuffling of DNA encoding human GST M1-1 and GST M2-2 was screened with eight alternative…”
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Identification of functionally diverging quasi‐species in molecular enzyme evolution by Kurtovic, Sanela, Emrén, Lars O., Runarsdottír, Arna, Larsson, Anna‐Karin, Mannervik, Bengt

“…New functional properties and altered structures of proteins arise in natural molecular evolution. The underlying mechanisms are mimicked in vitro by DNA…”
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Interactions of drugs and an oligonucleotide with charged membranes analyzed by immobilized liposome chromatography by Lundquist, Anna, Engvall, Caroline, Boija, Elisabet, Kurtovic, Sanela, Chattopadhyaya, Jyoti, Hägglund, Christine Lagerquist, Lundahl§, Per

“…We studied the effect of charged lipids or detergent on the retention of drugs and an oligonucleotide by immobilized liposome chromatography to characterize…”
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