Search Results - "Kurth, J."

Davis–Beirut Reaction: Diverse Chemistries of Highly Reactive Nitroso Intermediates in Heterocycle Synthesis by Zhu, Jie S, Haddadin, Makhluf J, Kurth, Mark J

“…Conspectus Indazoles are an important class of nitrogen heterocycles because of their excellent performance in biologically relevant applications, such as in…”
Get full text

Self-monitoring of blood glucose in type 2 diabetes and long-term outcome: an epidemiological cohort study by Martin, S, Schneider, B, Heinemann, L, Lodwig, V, Kurth, H.-J, Kolb, H, Scherbaum, W. A

“…Aims/hypothesis The aim of this study was to obtain epidemiological data on self-monitoring of blood glucose (SMBG) in type 2 diabetes and to investigate the…”
Get full text

The effect of peri‐operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non‐cardiac surgical patients: a randomised, double‐blind placebo‐controlled trial by van Norden, J., Spies, C. D., Borchers, F., Mertens, M., Kurth, J., Heidgen, J., Pohrt, A., Mueller, A.

“…Summary Delirium occurs commonly following major non‐cardiac and cardiac surgery and is associated with: postoperative mortality; postoperative neurocognitive…”
Get full text

Microwave-Assisted Synthesis of 3‑Nitroindoles from N‑Aryl Enamines via Intramolecular Arene–Alkene Coupling by Nguyen, Huy H, Kurth, Mark J

“…A variety of N-aryl β-nitroenamines were effectively transformed into 3-nitroindoles in good yields and with complete regioselectivity via a rapid microwave…”
Get full text

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization by Cassidy-Stone, Ann, Chipuk, Jerry E., Ingerman, Elena, Song, Cheng, Yoo, Choong, Kuwana, Tomomi, Kurth, Mark J., Shaw, Jared T., Hinshaw, Jenny E., Green, Douglas R., Nunnari, Jodi

“…Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mitochondrial fusion proteins attenuate apoptosis by inhibiting release…”
Get full text

Analysis of Literacy Content in IEPs of Students With Complex Support Needs by Zagona, Alison L., Lansey, K. R., Kurth, J. A., Loyless, R., Stevens, Elizabeth A.

“…The Individualized Education Program (IEP) should include a summary of the student’s current skills and needs as well as annual goals that support their…”
Get full text

The Davis-Beirut Reaction: a novel entry into 2H-indazoles and indazolones. Recent biological activity of indazoles by Haddadin, Makhluf J, Conrad, Wayne E, Kurth, Mark J

“…A novel, easy method for the syntheses of richly diversified 2H-indazoles and indazolones, called the Davis-Beirut reaction, and other recent 2H-indazole…”
Get more information

External radiation exposure, excretion, and effective half-life in 177Lu-PSMA-targeted therapies by Kurth, J., Krause, B. J., Schwarzenböck, S. M., Stegger, L., Schäfers, M., Rahbar, K.

“…Background Prostate-specific membrane antigen (PSMA)-targeted therapy with 177 Lu-PSMA-617 is a therapeutic option for patients with metastatic…”
Get full text

Potent, Metabolically Stable Benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR Inhibitors for Polycystic Kidney Disease by Snyder, David S, Tradtrantip, Lukmanee, Yao, Chenjuan, Kurth, Mark J, Verkman, A. S

“…We previously reported the discovery of pyrimido-pyrrolo-quinoxalinedione (PPQ) inhibitors of the cystic fibrosis transmembrane conductance regulator (CFTR)…”
Get full text

Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies by Abdildinova, Aizhan, Kurth, Mark J, Gong, Young-Dae

“…Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful…”
Get full text

The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis by Shuai, Zongwen, Wang, Jinjun, Badamagunta, Madhu, Choi, Jinjung, Yang, Guoxiang, Zhang, Weici, Kenny, Thomas P., Guggenheim, Kathryn, Kurth, Mark J., Ansari, Aftab A., Voss, John, Coppel, Ross L., Invernizzi, Pietro, Leung, Patrick S.C., Gershwin, M. Eric

“…The identification of environmental factors that lead to loss of tolerance has been coined the holy grail of autoimmunity. Our work has focused on the…”
Get full text

Halothane‐induced hepatitis: Paradigm or paradox for drug‐induced liver injury by Kurth, Mark J, Yokoi, Tsuyoshi, Gershwin, M. Eric

Get full text

[ 18 F]-florbetaben PET/CT Imaging in the Alzheimer's Disease Mouse Model APPswe/PS1dE9 by Stenzel, J, Rühlmann, C, Lindner, T, Polei, S, Teipel, S, Kurth, J, Rominger, A, Krause, B J, Vollmar, B, Kuhla, A

“…Positron-emission-tomography (PET) using 18F labeled florbetaben allows noninvasive in vivo-assessment of amyloid-beta (Aβ), a pathological hallmark of…”
Get more information

Carbon−Carbon Bond-Forming Solid-Phase Reactions. Part II by Sammelson, Robert E, Kurth, Mark J

“…Solid-phase organic synthesis has become a very efficient model for production of combinatorial libraries, and with the implementation of high-throughput…”
Get full text

Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis–Beirut Reaction by Zhu, Jie S, Son, Jung-Ho, Teuthorn, Andrew P, Haddadin, Makhluf J, Kurth, Mark J, Tantillo, Dean J

“…The discovery of a new variation on the Davis–Beirut reaction is described in which an atypical heterocyclic framework (the anthranil or benzo­[c]­isoxazole…”
Get full text

Stannous Chloride in Alcohol:  A One-Pot Conversion of 2-Nitro-N-arylbenzamides to 2,3-Dihydro-1H-quinazoline-4-ones by Yoo, Choong Leol, Fettinger, James C, Kurth, Mark J

“…A novel one-step synthesis of 2,3-dihydro-1H-quinazolin-4-ones from 2-nitrobenzamides is reported. These reactions are mediated by stannous chloride in 0.02 M…”
Get full text

Environment and primary biliary cirrhosis: Electrophilic drugs and the induction of AMA by Leung, Patrick S.C, Wang, Jinjun, Naiyanetr, Phornnop, Kenny, Thomas P, Lam, Kit S, Kurth, Mark J, Gershwin, M. Eric

“…Abstract Environmental stimulation is a major factor in the initiation and perpetuation of autoimmune diseases. We have addressed this issue and focused on…”
Get full text

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport by Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., Goodyear, L. J.

“…Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. T Hayashi , M F Hirshman , E J Kurth , W W…”
Get full text

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle by Merrill, G.F, Kurth, E.J, Hardie, D.G, Winder, W.W

“…5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) has previously been reported to be taken up into cells and phosphorylated to form ZMP, an analog of…”
Get full text

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease by Lue, Lih-Fen, Kuo, Yu-Min, Roher, Alex E., Brachova, Libuse, Shen, Yong, Sue, Lucia, Beach, Thomas, Kurth, Janice H., Rydel, Russel E., Rogers, Joseph

“…We have characterized amyloid β peptide (Aβ. concentration, Aβ deposition, paired helical filament formation, cerebrovascular amyloid angiopathy,…”
Get full text