Search Results - "Kurtenbach, Stefan"

Single-cell analysis reveals new evolutionary complexity in uveal melanoma by Durante, Michael A., Rodriguez, Daniel A., Kurtenbach, Stefan, Kuznetsov, Jeffim N., Sanchez, Margaret I., Decatur, Christina L., Snyder, Helen, Feun, Lynn G., Livingstone, Alan S., Harbour, J. William

“…Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous melanoma, is largely unresponsive to checkpoint immunotherapy. Here, we…”
Get full text

Single-cell analysis of olfactory neurogenesis and differentiation in adult humans by Durante, Michael A., Kurtenbach, Stefan, Sargi, Zoukaa B., Harbour, J. William, Choi, Rhea, Kurtenbach, Sarah, Goss, Garrett M., Matsunami, Hiroaki, Goldstein, Bradley J.

“…The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site…”
Get full text

Punctuated evolution of canonical genomic aberrations in uveal melanoma by Field, Matthew G., Durante, Michael A., Anbunathan, Hima, Cai, Louis Z., Decatur, Christina L., Bowcock, Anne M., Kurtenbach, Stefan, Harbour, J. William

“…Cancer is thought to arise through the accumulation of genomic aberrations evolving under Darwinian selection. However, it remains unclear when the aberrations…”
Get full text

PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma by Field, Matthew G, Decatur, Christina L, Kurtenbach, Stefan, Gezgin, Gülçin, van der Velden, Pieter A, Jager, Martine J, Kozak, Kaleigh N, Harbour, J William

“…Uveal melanoma (UM) can be classified by gene expression profiling (GEP) into Class 1 (low metastatic risk) and Class 2 (high metastatic risk), the latter…”
Get full text

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies by Yang, Hui, Kurtenbach, Stefan, Guo, Ying, Lohse, Ines, Durante, Michael A., Li, Jianping, Li, Zhaomin, Al-Ali, Hassan, Li, Lingxiao, Chen, Zizhen, Field, Matthew G., Zhang, Peng, Chen, Shi, Yamamoto, Shohei, Li, Zhuo, Zhou, Yuan, Nimer, Stephen D., Harbour, J. William, Wahlestedt, Claes, Xu, Mingjiang, Yang, Feng-Chun

“…Additional Sex Combs-Like 1 (ASXL1) is mutated at a high frequency in all forms of myeloid malignancies associated with poor prognosis. We generated a Vav1…”
Get full text

ChIPprimersDB: a public repository of verified qPCR primers for chromatin immunoprecipitation (ChIP) by Kurtenbach, Stefan, Reddy, Rohit, Harbour, J William

“…Abstract Chromatin immunoprecipitation (ChIP) has ushered in a new era of scientific discovery by allowing new insights into DNA-protein interactions. ChIP is…”
Get full text

Uphyloplot2: visualizing phylogenetic trees from single-cell RNA-seq data by Kurtenbach, Stefan, Cruz, Anthony M, Rodriguez, Daniel A, Durante, Michael A, Harbour, J William

“…Recent advances in single cell sequencing technologies allow for greater resolution in assessing tumor clonality using chromosome copy number variations…”
Get full text

Pannexin1 stabilizes synaptic plasticity and is needed for learning by Prochnow, Nora, Abdulazim, Amr, Kurtenbach, Stefan, Wildförster, Verena, Dvoriantchikova, Galina, Hanske, Julian, Petrasch-Parwez, Elisabeth, Shestopalov, Valery I, Dermietzel, Rolf, Manahan-Vaughan, Denise, Zoidl, Georg

“…Pannexin 1 (Panx1) represents a class of vertebrate membrane channels, bearing significant sequence homology with the invertebrate gap junction proteins, the…”
Get full text

Gap junction modulation and its implications for heart function by Kurtenbach, Stefan, Kurtenbach, Sarah, Zoidl, Georg

“…Gap junction communication (GJC) mediated by connexins is critical for heart function. To gain insight into the causal relationship of molecular mechanisms of…”
Get full text

Pannexin1 channel proteins in the zebrafish retina have shared and unique properties by Kurtenbach, Sarah, Prochnow, Nora, Kurtenbach, Stefan, Klooster, Jan, Zoidl, Christiane, Dermietzel, Rolf, Kamermans, Maarten, Zoidl, Georg

“…In mammals, a single pannexin1 gene (Panx1) is widely expressed in the CNS including the inner and outer retinae, forming large-pore voltage-gated membrane…”
Get full text

Olfaction in three genetic and two MPTP-induced Parkinson's disease mouse models by Kurtenbach, Stefan, Wewering, Sonja, Hatt, Hanns, Neuhaus, Eva M, Lübbert, Hermann

“…Various genetic or toxin-induced mouse models are frequently used for investigation of early PD pathology. Although olfactory impairment is known to precede…”
Get full text

A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model by Whyte-Fagundes, Paige, Kurtenbach, Stefan, Zoidl, Christiane, Shestopalov, Valery I, Carlen, Peter L, Zoidl, Georg

“…Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory…”
Get full text

The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia by Kurtenbach, Stefan, Gießl, Andreas, Strömberg, Siv, Kremers, Jan, Atorf, Jenny, Rasche, Sebastian, Neuhaus, Eva M., Hervé, Denis, Brandstätter, Johann Helmut, Asan, Esther, Hatt, Hanns, Kilimann, Manfred W.

“…BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA…”
Get full text

The Inflammasome-Dependent Dysfunction and Death of Retinal Ganglion Cells after Repetitive Intraocular Pressure Spikes by Spurlock, Markus, An, Weijun, Reshetnikova, Galina, Wen, Rong, Wang, Hua, Braha, Michelle, Solis, Gabriela, Kurtenbach, Stefan, Galindez, Orlando J, de Rivero Vaccari, Juan Pablo, Chou, Tsung-Han, Porciatti, Vittorio, Shestopalov, Valery I

“…The dysfunction and selective loss of retinal ganglion cells (RGCs) is a known cause of vision loss in glaucoma and other neuropathies, where ocular…”
Get full text

Molecular evolution of a chordate specific family of G protein-coupled receptors by Kurtenbach, Stefan, Mayer, Christoph, Pelz, Thomas, Hatt, Hanns, Leese, Florian, Neuhaus, Eva M

“…Chordate evolution is a history of innovations that is marked by physical and behavioral specializations, which led to the development of a variety of forms…”
Get full text

Odorant-dependent generation of nitric oxide in Mammalian olfactory sensory neurons by Brunert, Daniela, Kurtenbach, Stefan, Isik, Sonnur, Benecke, Heike, Gisselmann, Günter, Schuhmann, Wolfgang, Hatt, Hanns, Wetzel, Christian H

“…The gaseous signalling molecule nitric oxide (NO) is involved in various physiological processes including regulation of blood pressure, immunocytotoxicity and…”
Get full text

Abstract 3027: Role of BCOR in retinoblastoma by Zhang, Michelle Garying, Owens, Dawn, Kurtenbach, Stefan, Kuznetsov, Jeffim, Fields, Matthew, Pelaez, Daniel, Harbour, James W.

“…Abstract Retinoblastoma, which is usually initiated by the biallelic mutational inactivation of RB1, is the most common primary eye cancer in children and is…”
Get full text

Abstract 12709: Characterization of Growth Hormone Releasing Hormone Receptor During Cardiomyogenesis by Wanschel, Amarylis, Chatzistergos, Konstantinos, Salerno, Alessandro, Valasaki, Krystalenia, Kurtenbach, Stefan, Balkan, Wayne, Dykxhoorn, Derek, Schally, Andrew, Hare, Joshua M

“…IntroductionDifferentiation and expansion of cardiomyocytes from human-induced pluripotent stem cells is a poorly understood process, and the signals promoting…”
Get full text

Abstract 2764: Mechanisms of genomic-microenvironmental interactions in uveal melanoma by Kaler, Christopher J., Dollar, James J., Kurtenbach, Stefan, Kuznetsov, Jeffim N., Durante, Michael A., Harbour, J. William

“…Abstract Uveal melanoma (UM) is the most common primary eye cancer and has a high rate of metastasis with liver tropism. UM can be stratified according to…”
Get full text

BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas by Field, Matthew G, Kuznetsov, Jeffim N, Bussies, Parker L, Cai, Louie Z, Alawa, Karam A, Decatur, Christina L, Kurtenbach, Stefan, Harbour, J William

“…The strong association between mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in…”
Get full text