Infection with COVID‐19 is no longer a public emergency: But what about degenerative dementia?

Infection with COVID‐19 is no longer a public emergency: But what about degenerative dementia?

Although no longer considered a public health threat, post‐COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID‐19. Recent studies have also suggested that COVID may be represent a critical risk factor for the development of Alzheimer&...

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Bibliographic Details
Published in:Journal of medical virology Vol. 95; no. 9; p. e29072
Main Authors: Yulug, Burak, Ayyıldız, Behçet, Ayyıldız, Sevilay, Sayman, Dila, Salar, Ali Behram, Cankaya, Seyda, Ozdemir Oktem, Ece, Ozsimsek, Ahmet, Kurt, Cagla Ceren, Lakadamyalı, Hatice, Akturk, Aynur, Altay, Özlem, Hanoglu, Lutfu, Velioglu, Halil Aziz, Mardinoglu, Adil
Format: Journal Article
Language:English
Published: London Wiley Subscription Services, Inc 01-09-2023
Subjects:
Alzheimer's disease
cognition
Cognitive ability
Connectivity analysis
COVID infection
COVID-19
Dementia
Dementia disorders
fMRI
Health risks
hippocampal connectivity
Hippocampus
Neural networks
Neurodegenerative diseases
Public health
Risk factors
Viral diseases
Virology
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Summary:Although no longer considered a public health threat, post‐COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID‐19. Recent studies have also suggested that COVID may be represent a critical risk factor for the development of Alzheimer's disease (AD). We compared 17 COVID patients with 20 controls and evaluated the effects of COVID‐19 on general cognitive performance, hippocampal volume, and connections using structural and seed‐based connectivity analysis. We showed that COVID patients exhibited considerably worse cognitive functioning and increased hippocampal connectivity supported by the strong correlation between hippocampal connectivity and cognitive scores. Our findings of higher hippocampal connectivity with no observable hippocampal morphological changes even in mild COVID cases may be represent evidence of a prestructural compensatory mechanism for stimulating additional neuronal resources to combat cognitive dysfunction as recently shown for the prodromal stages of degenerative cognitive disorders. Our findings may be also important in light of recent data showing that other viral infections as well as COVID may constitute a critical risk factor for the development of AD. To our knowledge, this is the first study that investigated network differences in COVID patients, with a particular focus on compensatory hippocampal connectivity.
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ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.29072