Search Results - "Kursula, I."

Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase by Kursula, I., Salin, M., Sun, J., Norledge, B.V., Haapalainen, A.M., Sampson, N.S., Wierenga, R.K.

“…The conformational switch from open to closed of the flexible loop 6 of triosephosphate isomerase (TIM) is essential for the catalytic properties of TIM. Using…”
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Crystal structure of non-fused glutathione S-transferase from Schistosoma japonicum in complex with glutathione by Kursula, I, Heape, A M, Kursula, P

“…Schistosoma japonicum glutathione S-transferase (SjGST) is a common fusion tag in recombinant protein production, and its 3-dimensional structure has been…”
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Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite by Singh, Bishal K, Sattler, Julia M, Chatterjee, Moon, Huttu, Jani, Schüler, Herwig, Kursula, Inari

“…Apicomplexan parasites, such as the malaria-causing Plasmodium , utilize an actin-based motor for motility and host cell invasion. The actin filaments of these…”
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Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical Giardia lamblia assemblage A and B isolates by Saghaug, Christina S, Klotz, Christian, Kallio, Juha P, Brattbakk, Hans-Richard, Stokowy, Tomasz, Aebischer, Toni, Kursula, Inari, Langeland, Nina, Hanevik, Kurt

“…Treatment-refractory cases have increased rapidly within the last decade. No markers of resistance nor a standardized susceptibility test have been established…”
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Structural Basis for Parasite-Specific Functions of the Divergent Profilin of Plasmodium falciparum by Kursula, Inari, Kursula, Petri, Ganter, Markus, Panjikar, Santosh, Matuschewski, Kai, Schüler, Herwig

“…Profilins are key regulators of actin dynamics. They sequester actin monomers, forming a pool for rapid polymer formation stimulated by proteins such as…”
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Genetic Variation in Metronidazole Metabolism and Oxidative Stress Pathways in Clinical Giardia lamblia Assemblage A and B Isolates [Corrigendum] by Saghaug, Christina S, Klotz, Christian, Kallio, Juha P, Brattbakk, Hans-Richard, Stokowy, Tomasz, Aebischer, Toni, Kursula, Inari, Langeland, Nina, Hanevik, Kurt

“…Saghaug CS, Klotz C, Kallio JP, et al. Infect Drug Resist. 2019;12:1221-1235. The authors have advised NR-1 was used throughout the paper to denote the gene…”
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Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII by Wigren, Edvard, Bourhis, Jean-Marie, Kursula, Inari, Guy, Jodie E., Lindqvist, Ylva

“…LMAN1 is a glycoprotein receptor, mediating transfer from the ER to the ER–Golgi intermediate compartment. Together with the co-receptor MCFD2, it transports…”
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Crystal Structure of Triosephosphate Isomerase Complexed with 2-Phosphoglycolate at 0.83-Aa Resolution by Kursula, I, Wierenga, R K

“…The atomic resolution structure of Leishmania mexicana triosephosphate isomerase complexed with 2-phosphoglycolate shows that this transition state analogue is…”
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Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning by Sultana, Azmiri, Alexeev, Igor, Kursula, Inari, Mäntsälä, Pekka, Niemi, Jarmo, Schneider, Gunter

“…The crystal structure of aclacinomycin oxidoreductase (AknOx), a tailoring enzyme involved in the biosynthesis of the polyketide antibiotic aclacinomycin, was…”
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Structural studies on titin and titin kinase's downstream signaling pathway by Müller, S., Kursula, I., Wilmanns, M.

“…Abstract only…”
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The crystal structure of the ERGIC-53/MCFD2 transport receptor complex by Wigren, Edvard, Bourhis, Jean-Marie, Kursula, Inari, Guy, Jodie E., Lindqvist, Ylva

“…Abstract only…”
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Structure of the PB1 domain of NBR1 and complex formation with the PB1 domain of p62 by Müller, S., Kursula, I., Wilmanns, M.

“…Abstract only…”
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Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332 by Nilsson, Sandra, Moll, Kirsten, Angeletti, Davide, Albrecht, Letusa, Kursula, Inari, Jiang, Ning, Sun, Xiaodong, Berzins, Klavs, Wahlgren, Mats, Chen, Qijun

“…Studies on Pf332, a major Plasmodium falciparum blood-stage antigen, have largely been hampered by the cross-reactive nature of antibodies generated against…”
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A neutralizing antibody against human DNA polymerase ε inhibits cellular but not SV40 DNA replication by Pospiech, Helmut, Kursula, Inari, Abdel-Aziz, Waleed, Malkas, Linda, Uitto, Lahja, Kastelli, Maaret, Vihinen-Ranta, Maija, Eskelinen, Sinikka, Syväoja, Juhani E.

“…The contribution of human DNA polymerase ε to nuclear DNA replication was studied. Antibody K18 that specifically inhibits DNA polymerase activity of human DNA…”
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Structural determinants for ligand binding and catalysis of 
triosephosphate isomerase by Kursula, Inari, Partanen, Sanna, Lambeir, Anne‐Marie, Antonov, Dmitry M., Augustyns, Koen, Wierenga, Rik K.

“…The crystal structure of leishmania triosephosphate isomerase (TIM) complexed with 2‐(N‐formyl‐N‐hydroxy)‐aminoethyl phosphonate (IPP) highlights the…”
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The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase by Lambeir, Anne‐Marie, Backmann, Jan, Ruiz‐Sanz, Javier, Filimonov, Vladimir, Nielsen, Jens Erik, Kursula, Inari, Norledge, Brian V., Wierenga, Rik K.

“…The amino acid sequence of Leishmania mexicana triose phosphate isomerase is unique in having at position 65 a glutamic acid instead of a glutamine. The…”
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