Search Results - "Kurreck, Jens"

RNA Interference: From Basic Research to Therapeutic Applications by Kurreck, Jens

“…An efficient mechanism for the sequence-specific inhibition of gene expression is RNA interference. In this process, double-stranded RNA molecules induce…”
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Effects of genomic disruption of a guanine quadruplex in the 5′ UTR of the Bcl‐2 mRNA in melanoma cells by Serikawa, Tatsuo, Eberle, Jürgen, Kurreck, Jens

“…G‐quadruplex structures in the 5′ UTR of mRNAs have been shown to suppress translation. However, all experiments published so far made use of artificial…”
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Coxsackievirus B3-Its Potential as an Oncolytic Virus by Geisler, Anja, Hazini, Ahmet, Heimann, Lisanne, Kurreck, Jens, Fechner, Henry

“…Oncolytic virotherapy represents one of the most advanced strategies to treat otherwise untreatable types of cancer. Despite encouraging developments in recent…”
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Quantification of Major Bacteria and Yeast Species in Kefir Consortia by Multiplex TaqMan qPCR by Nejati, Fatemeh, Junne, Stefan, Kurreck, Jens, Neubauer, Peter

“…Kefir grains are complex microbial systems of several groups of microorganisms. The identification and quantification of the microbial composition of milk…”
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Generation of a 3D Liver Model Comprising Human Extracellular Matrix in an Alginate/Gelatin-Based Bioink by Extrusion Bioprinting for Infection and Transduction Studies by Hiller, Thomas, Berg, Johanna, Elomaa, Laura, Röhrs, Viola, Ullah, Imran, Schaar, Katrin, Dietrich, Ann-Christin, Al-Zeer, Munir A, Kurtz, Andreas, Hocke, Andreas C, Hippenstiel, Stefan, Fechner, Henry, Weinhart, Marie, Kurreck, Jens

“…Bioprinting is a novel technology that may help to overcome limitations associated with two-dimensional (2D) cell cultures and animal experiments, as it allows…”
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High performing additively manufactured bone scaffolds based on copper substituted diopside by Pang, Shumin, Wu, Dongwei, Kamutzki, Franz, Kurreck, Jens, Gurlo, Aleksander, Hanaor, Dorian A.H.

“…[Display omitted] •Robocasting of precipitation derived 0–3 at.% copper-doped diopside.•Copper-doping improved mechanical properties.•1 at.% copper-doping…”
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Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif by Arora, Amit, Dutkiewicz, Mariola, Scaria, Vinod, Hariharan, Manoj, Maiti, Souvik, Kurreck, Jens

“…Guanine-rich sequences can adopt intramolecular four-stranded structures, called G-quadruplexes. These motifs have been intensively investigated on the DNA…”
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Generation of a Perfusable 3D Lung Cancer Model by Digital Light Processing by Mei, Yikun, Wu, Dongwei, Berg, Johanna, Tolksdorf, Beatrice, Roehrs, Viola, Kurreck, Anke, Hiller, Thomas, Kurreck, Jens

“…Lung cancer still has one of the highest morbidity and mortality rates among all types of cancer. Its incidence continues to increase, especially in developing…”
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Combination of FOLFOXIRI Drugs with Oncolytic Coxsackie B3 Virus PD-H Synergistically Induces Oncolysis in the Refractory Colorectal Cancer Cell Line Colo320 by Girod, Maxim, Geisler, Anja, Hinze, Luisa, Elsner, Leslie, Dieringer, Babette, Beling, Antje, Kurreck, Jens, Fechner, Henry

“…FOLFOXIRI chemotherapy is a first-line therapy for advanced or metastatic colorectal cancer (CRC), yet its therapeutic efficacy remains limited…”
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Identification and characterization of RNA guanine-quadruplex binding proteins by von Hacht, Annekathrin, Seifert, Oliver, Menger, Marcus, Schütze, Tatjana, Arora, Amit, Konthur, Zoltán, Neubauer, Peter, Wagner, Anke, Weise, Christoph, Kurreck, Jens

“…Guanine quadruplex (G-quadruplex) motifs in the 5' untranslated region (5'-UTR) of mRNAs were recently shown to influence the efficiency of translation. In the…”
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Bioprinted Multi-Cell Type Lung Model for the Study of Viral Inhibitors by Berg, Johanna, Weber, Zia, Fechler-Bitteti, Mona, Hocke, Andreas C, Hippenstiel, Stefan, Elomaa, Laura, Weinhart, Marie, Kurreck, Jens

“…Influenza A virus (IAV) continuously causes epidemics and claims numerous lives every year. The available treatment options are insufficient and the limited…”
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Bioprinted Cancer Model of Neuroblastoma in a Renal Microenvironment as an Efficiently Applicable Drug Testing Platform by Wu, Dongwei, Berg, Johanna, Arlt, Birte, Röhrs, Viola, Al-Zeer, Munir A, Deubzer, Hedwig E, Kurreck, Jens

“…Development of new anticancer drugs with currently available animal models is hampered by the fact that human cancer cells are embedded in an animal-derived…”
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Silencing of Mcl-1 overcomes resistance of melanoma cells against TRAIL-armed oncolytic adenovirus by enhancement of apoptosis by Tolksdorf, Beatrice, Zarif, Sina, Eberle, Jürgen, Hazini, Ahmet, Dieringer, Babette, Jönsson, Franziska, Kreppel, Florian, Kurreck, Jens, Fechner, Henry

“…Arming of oncolytic viruses with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown as a viable approach to increase the antitumor…”
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Three-Dimensional-Bioprinted Non-Small Cell Lung Cancer Models in a Mouse Phantom for Radiotherapy Research by Mei, Yikun, Lakotsenina, Elena, Wegner, Marie, Hehne, Timon, Krause, Dieter, Hakimeh, Dani, Wu, Dongwei, Schültke, Elisabeth, Hausmann, Franziska, Kurreck, Jens, Tolksdorf, Beatrice

“…Lung cancer continues to have one of the highest morbidity and mortality rates of any cancer. Although radiochemotherapy, in combination with immunotherapy,…”
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Xeno-Free 3D Bioprinted Liver Model for Hepatotoxicity Assessment by Ali, Ahmed S M, Berg, Johanna, Roehrs, Viola, Wu, Dongwei, Hackethal, Johannes, Braeuning, Albert, Woelken, Lisa, Rauh, Cornelia, Kurreck, Jens

“…Three-dimensional (3D) bioprinting is one of the most promising methodologies that are currently in development for the replacement of animal experiments…”
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Combining RNA Interference and RIG-I Activation to Inhibit Hepatitis E Virus Replication by Ziersch, Mathias, Harms, Dominik, Neumair, Lena, Kurreck, Anke, Johne, Reimar, Bock, C-Thomas, Kurreck, Jens

“…Hepatitis E virus (HEV) poses a significant global health threat, with an estimated 20 million infections occurring annually. Despite being a self-limiting…”
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Evaluating the Suitability of 3D Bioprinted Samples for Experimental Radiotherapy: A Pilot Study by Al-Zeer, Munir A., Prehn, Franziska, Fiedler, Stefan, Lienert, Ulrich, Krisch, Michael, Berg, Johanna, Kurreck, Jens, Hildebrandt, Guido, Schültke, Elisabeth

“…Radiotherapy is an important component in the treatment of lung cancer, one of the most common cancers worldwide, frequently resulting in death within only a…”
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Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader Sequence by Tolksdorf, Beatrice, Nie, Chuanxiong, Niemeyer, Daniela, Röhrs, Viola, Berg, Johanna, Lauster, Daniel, Adler, Julia M., Haag, Rainer, Trimpert, Jakob, Kaufer, Benedikt, Drosten, Christian, Kurreck, Jens

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected almost 200 million people worldwide and led to approximately 4 million deaths as of…”
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Specific circulating microRNAs during hepatitis E infection can serve as indicator for chronic hepatitis E by Harms, Dominik, Choi, Mira, Allers, Kristina, Wang, Bo, Pietsch, Heiko, Papp, C.-Patrick, Hanisch, Lina, Kurreck, Jens, Hofmann, Jörg, Bock, C.-Thomas

“…Hepatitis E virus (HEV) genotypes 3 and 4 (HEV-3, HEV-4) infections are an emerging public health issue in industrialized countries. HEV-3 and −4 are usually…”
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Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations by Yehia, Heba, Westarp, Sarah, Röhrs, Viola, Kaspar, Felix, Giessmann, Robert T, Klare, Hendrik F T, Paulick, Katharina, Neubauer, Peter, Kurreck, Jens, Wagner, Anke

“…The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study,…”
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