Search Results - "Kuro‐o, Makoto"

Phosphate as a Pathogen of Arteriosclerosis and Aging by Kuro-o, Makoto

“…During the evolution of skeletons, terrestrial vertebrates acquired strong bones made of calcium–phosphate. By keeping the extracellular fluid in a…”
Get full text

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho by Dias, Gisele Pereira, Murphy, Tytus, Stangl, Doris, Ahmet, Selda, Morisse, Benjamin, Nix, Alina, Aimone, Lindsey J., Aimone, James B., Kuro-O, Makoto, Gage, Fred H., Thuret, Sandrine

“…Daily calorie restriction (CR) and intermittent fasting (IF) enhance longevity and cognition but the effects and mechanisms that differentiate these two…”
Get full text

Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP‐PKA pathway by Wang, Yuhong, Kuro‐o, Makoto, Sun, Zhongjie

“…Summary Klotho is a recently discovered anti‐aging gene. The purpose of this study was to investigate whether klotho gene transfer attenuates superoxide…”
Get full text

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule by Hu, Ming Chang, Shi, Mingjun, Zhang, Jianning, Pastor, Johanne, Nakatani, Teruyo, Lanske, Beate, Razzaque, M. Shawkat, Rosenblatt, Kevin P, Baum, Michel G, Kuro-o, Makoto, Moe, Orson W

“…Klotho has profound effects on phosphate metabolism, but the mechanisms of how Klotho affects phosphate homeostasis is unknown. We detected Klotho in the…”
Get full text

Roles of fibroblast growth factor 21 in the control of depression‐like behaviours after social defeat stress in male rodents by Usui, Naoki, Yoshida, Masahide, Takayanagi, Yuki, Nasanbuyan, Naranbat, Inutsuka, Ayumu, Kurosu, Hiroshi, Mizukami, Hiroaki, Mori, Yoshiyuki, Kuro‐o, Makoto, Onaka, Tatsushi

“…Fibroblast growth factor 21 (FGF21) modulates energy metabolism and neuroendocrine stress responses. FGF21 synthesis is increased after environmental or…”
Get full text

Klotho regulates the myogenic response of muscle to mechanical loading and exercise by Ochi, Eisuke, Barrington, Alice, Wehling‐Henricks, Michelle, Avila, Marcus, Kuro‐o, Makoto, Tidball, James G.

“…New Findings What is the central question of this study? Does the hormone Klotho affect the myogenic response of muscle cells to mechanical loading or…”
Get full text

Differential regulation of renal Klotho and FGFR1 in normal and uremic rats by Muñoz‐Castañeda, Juan R., Herencia, Carmen, Pendón‐Ruiz de Mier, Maria Victoria, Rodriguez‐Ortiz, Maria Encarnación, Diaz‐Tocados, Juan M., Vergara, Noemi, Martínez‐Moreno, Julio M., Salmerón, Maria Dolores, Richards, William G., Felsenfeld, Arnold, Kuro‐O, Makoto, Almadén, Yolanda, Rodríguez, Mariano

“…ABSTRACT In renal failure, hyperphosphatemia occurs despite a marked elevation in serum fibroblast growth factor (FGF)‐23. Abnormal regulation of the…”
Get full text

Role of Klotho in Aging, Phosphate Metabolism, and CKD by John, George B., PhD, Cheng, Chung-Yi, MD, PhD, Kuro-o, Makoto, MD, PhD

“…The klotho gene ( KL ) was identified first as a putative aging-suppressor gene that extended life span when overexpressed and accelerated aging-like…”
Get full text

Modulation of Klotho expression in injured muscle perturbs Wnt signalling and influences the rate of muscle growth by Welc, Steven S., Wehling‐Henricks, Michelle, Kuro‐o, Makoto, Thomas, Kyle A., Tidball, James G.

“…New Findings What is the central question of this study? Does modulating the expression of Klotho affect myogenesis following acute injury of healthy,…”
Get full text

Impact of etelcalcetide on fibroblast growth factor‐23 and calciprotein particles in patients with secondary hyperparathyroidism undergoing haemodialysis by Hashimoto, Yusaku, Kato, Sawako, Kuro‐o, Makoto, Miura, Yutaka, Itano, Yuya, Ando, Masahiko, Kuwatsuka, Yachiyo, Maruyama, Shoichi

“…Aim Recently, we demonstrated the efficacy of etelcalcetide in the control of secondary hyperparathyroidism (SHPT). This post hoc analysis aimed to evaluate…”
Get full text

Elevated urinary angiotensinogen excretion links central and renal hemodynamic alterations by Kosaki, Keisei, Park, Jiyeon, Matsui, Masahiro, Sugaya, Takeshi, Kuro-o, Makoto, Saito, Chie, Yamagata, Kunihiro, Maeda, Seiji

“…Inappropriate activation of intrarenal renin–angiotensin system (RAS) may contribute to the pathogenesis of cardio-renal syndrome (CRS). We aimed to examine…”
Get full text

Circulating fibroblast growth factor 21 links hemodynamics with kidney function in middle-aged and older adults: A mediation analysis by Matsui, Masahiro, Kosaki, Keisei, Kuro-O, Makoto, Saito, Chie, Yamagata, Kunihiro, Maeda, Seiji

“…Altered hemodynamics are commonly observed in individuals with declining renal function; however, the pathophysiological mechanisms linking renal dysfunction…”
Get full text

PTH, vitamin D, and the FGF‐23–klotho axis and heart: Going beyond the confines of nephrology by Navarro‐García, José Alberto, Fernández‐Velasco, María, Delgado, Carmen, Delgado, Juan F., Kuro‐o, Makoto, Ruilope, Luis M., Ruiz‐Hurtado, Gema

“…Background Profound disturbances in mineral metabolism are closely linked to the progression of chronic kidney disease. However, increasing clinical and…”
Get full text

Association between the intake of plant and animal proteins and the serum fibroblast growth factor-23 level in patients with chronic kidney disease analyzed by the isocaloric substitution model by Yoshioka, Masaki, Kosaki, Keisei, Matsui, Masahiro, Mori, Shoya, Nishitani, Natsumi, Saito, Chie, Yamagata, Kunihiro, Kuro-o, Makoto, Maeda, Seiji

“…Fibroblast growth factor-23 (FGF23) is a phosphaturic hormone secreted by the bone in response to dietary phosphate intake. Since the phosphate content in the…”
Get full text

Association of circulating calciprotein particle levels with skeletal muscle mass and strength in middle-aged and older adults by Yoshioka, Masaki, Kosaki, Keisei, Matsui, Masahiro, Okabe, Naoya, Saito, Chie, Yamagata, Kunihiro, Kuro-O, Makoto, Maeda, Seiji

“…Calciprotein particles (CPPs) are tiny mineral-protein aggregates consisting of calcium-phosphate and fetuin-A. Recent studies have suggested that CPPs may…”
Get full text

Mineral metabolism and aging. by Kuro-O, Makoto

“…Analysis of a mutant mouse exhibiting accelerated aging identified phosphorus as a pro-aging factor in mammals. In the blood, phosphorus exists in the form of…”
Get more information

Serum Endocrine Fibroblast Growth Factors as Potential Biomarkers for Chronic Kidney Disease and Various Metabolic Dysfunctions in Aged Patients by Yamamoto, Shogo, Koyama, Daisuke, Igarashi, Ryo, Maki, Takumi, Mizuno, Hiroyuki, Furukawa, Yusuke, Kuro-o, Makoto

“…Objective To prolong the health expectancy, it is important to prevent age-related diseases, such as osteoporosis and cerebrovascular disease, which are major…”
Get full text

Klotho and endocrine fibroblast growth factors: markers of chronic kidney disease progression and cardiovascular complications? by Kuro-o, Makoto

“…ABSTRACT Three members of the fibroblast growth factor (FGF) family, FGF19, FGF21 and FGF23, are different from the other members in two major aspects. First,…”
Get full text

High Salt Diet Impacts the Risk of Sarcopenia Associated with Reduction of Skeletal Muscle Performance in the Japanese Population by Yoshida, Yasuko, Kosaki, Keisei, Sugasawa, Takehito, Matsui, Masahiro, Yoshioka, Masaki, Aoki, Kai, Kuji, Tomoaki, Mizuno, Risuke, Kuro-O, Makoto, Yamagata, Kunihiro, Maeda, Seiji, Takekoshi, Kazuhiro

“…The World Health Organization has recommended 5 g/day as dietary reference intakes for salt. In Japan, the averages for men and women were 11.0 g/day and 9.3…”
Get full text

Replacing sedentary time for physical activity on bone density in patients with chronic kidney disease by Yoshioka, Masaki, Kosaki, Keisei, Matsui, Masahiro, Shibata, Ai, Oka, Koichiro, Kuro-o, Makoto, Saito, Chie, Yamagata, Kunihiro, Maeda, Seiji

“…Introduction This study aimed to examine the cross-sectional associations of sedentary time and physical activity time with bone density in patients with…”
Get full text