Search Results - "Kuro‐o, M."

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition by Jiang, L, Xiao, L, Sugiura, H, Huang, X, Ali, A, Kuro-o, M, Deberardinis, R J, Boothman, D A

“…Metastatic progression, including extravasation and micrometastatic outgrowth, is the main cause of cancer patient death. Recent studies suggest that cancer…”
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Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer by Wolf, I, Levanon-Cohen, S, Bose, S, Ligumsky, H, Sredni, B, Kanety, H, Kuro-o, M, Karlan, B, Kaufman, B, Koeffler, H P, Rubinek, T

“…Klotho is an anti-aging gene, which has been shown to inhibit the insulin and insulin-like growth factor 1 (IGF-1) pathways in mice hepatocytes and myocytes…”
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Adhesion of klotho-deficient eryptotic erythrocytes to endothelial cells by Abed, M., Towhid, S. T., Feger, M., Schmidt, S., Kuro-o, M., Gawaz, M., Lang, F.

“…Aim Suicidal erythrocyte death or eryptosis is characterized by cell shrinkage and phosphatidylserine exposure at the cell surface. Eryptotic erythrocytes may…”
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Metabolic reprogramming during TGF beta 1-induced epithelial-to-mesenchymal transition by Jiang, L, Xiao, L, Sugiura, H, Huang, X, Ali, A, Kuro-o, M, Deberardinis, R J, Boothman, D A

“…Metastatic progression, including extravasation and micrometastatic outgrowth, is the main cause of cancer patient death. Recent studies suggest that cancer…”
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Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging by Asuzu, D. T., Hayashi, Y., Izbeki, F., Popko, L. N., Young, D. L., Bardsley, M. R., Lorincz, A., Kuro‐o, M., Linden, D. R., Farrugia, G., Ordog, T.

“…Background  Gastrointestinal symptoms, particularly constipation, increase with aging, but their underlying mechanisms are poorly understood due to lack of…”
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Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases by Nagai, R, Saito, Y, Ohyama, Y, Aizawa, H, Suga, T, Nakamura, T, Kurabayashi, M, Kuroo, M

“…The human aging process is associated with vascular endothelial dysfunction. However, humoral factors which might protect against endothelial dysfunction…”
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Exploring patterns and extent of bias in estimating divergence time from mitochondrial DNA sequence data in a particular lineage: a case study of salamanders (order Caudata) by Zheng, Yuchi, Peng, Rui, Kuro-o, Masaki, Zeng, Xiaomao

“…In the practice of molecular dating, substitution saturation will bias the results if not properly modeled. Date estimates based on commonly used mitochondrial…”
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Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging by Utsugi, T., Ohno, T., Ohyama, Y., Uchiyama, T., Saito, Y., Matsumura, Y., Aizawa, H., Itoh, H., Kurabayashi, M., Kawazu, S., Tomono, S., Oka, Y., Suga, T., Kuro-o, M., Nabeshima, Y., Nagai, R.

“…We have recently identified a novel gene, klotho (kl), which may suppress several aging phenotypes. A defect of kl gene expression in the mouse results in a…”
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Relationship between aerobic fitness and nephron index in middle-aged and older adults by Takahashi, K., Kosaki, K., Tanahashi, K., Osuka, Y., Tanaka, K., Kuro-o, M., Maeda, S.

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Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse by Kawaguchi, H, Manabe, N, Chikuda, H, Nakamura, K, Kuroo, M

“…The mouse homozygous for a disruption of the klotho locus (KL-/- or klotho mouse) exhibited multiple pathological conditions resembling human aging. We…”
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Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis by Nagai, R, Kuro-o, M, Babij, P, Periasamy, M

“…We previously reported the characterization of a rabbit uterus cDNA clone (SMHC29) which encoded part of the light meromyosin of smooth muscle myosin heavy…”
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Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin by Wolf, I, Laitman, Y, Rubinek, T, Abramovitz, L, Novikov, I, Beeri, R, Kuro-O, M, Koeffler, H P, Catane, R, Freedman, L S, Levy-Lahad, E, Karlan, B Y, Friedman, E, Kaufman, B

“…Klotho is a transmembrane protein that can be shed and act as a circulating hormone and is a putative tumor suppressor in breast cancer. A functional variant…”
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Karyotypic evolution and organization of the highly repetitive DNA sequences in the Japanese shrew-moles, Dymecodon pilirostris and Urotrichus talpoides by Nakata, A, Yoshimura, A, Kuro-o, M, Obara, Y

“…The karyological relationship and organization of highly repetitive DNA sequences in Japanese shrew-moles were studied by zoo-blot hybridization and…”
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Developmentally regulated expression of vascular smooth muscle myosin heavy chain isoforms by Kuro-o, M, Nagai, R, Tsuchimochi, H, Katoh, H, Yazaki, Y, Ohkubo, A, Takaku, F

“…Two types of smooth muscle myosin heavy chain (MHC) isoforms, SM1 and SM2, were recently identified to have different carboxyl termini (Nagai, R., Kuro-o, M.,…”
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Connection Between B Lymphocyte and Osteoclast Differentiation Pathways by Manabe, Noriyo, Kawaguchi, Hiroshi, Chikuda, Hirotaka, Miyaura, Chisato, Inada, Masaki, Nagai, Ryozo, Nabeshima, Yo-ichi, Nakamura, Kozo, Sinclair, Angus M, Scheuermann, Richard H, Kuro-o, Makoto

“…Osteoclasts differentiate from the hemopoietic monocyte/macrophage cell lineage in bone marrow through cell-cell interactions between osteoclast progenitors…”
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Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women by Ogata, N, Matsumura, Y, Shiraki, M, Kawano, K, Koshizuka, Y, Hosoi, T, Nakamura, K, Kuro-o, M, Kawaguchi, H

“…Based on the fact that the klotho-deficient mouse exhibits multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints, we explored the…”
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Molecular cytogenetic analysis of the highly repetitive DNA in the genome of Apodemus argenteus, with comments on the phylogenetic relationships in the genus Apodemus by Fukushi, D, Kuro-O, M, Shichiri, M, Obara, Y, Tsuchiya, K

“…The DNA of Apodemus argenteus was digested with DraI, and the resultant DraI fragment of highly repetitive DNA was isolated and analyzed by DNA filter…”
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Na+/H+ exchanger by Kuro-o, M

“…Recent investigations have revealed that an enhancement of Na+/H+ exchange activity is a frequently observed ion transport abnormality in hypertensive…”
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Human Smooth Muscle Myosin Heavy Chain Isoforms as Molecular Markers for Vascular Development and Atherosclerosis by Aikawa, Masanori, Sivam, Palanisamy Nalla, Kuro-o, Makoto, Kimura, Kenjiro, Nakahara, Ken-ichi, Takewaki, Shun-ichi, Ueda, Makiko, Yamaguchi, Hiroshi, Yazaki, Yoshio, Periasamy, Muthu, Nagai, Ryozo

“…Smooth muscle myosin heavy chains (MHCs) exist in multiple isoforms. Rabbit smooth muscles contain at least three types of MHC isoformsSM1 (204 kD), SM2 (200…”
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Introduction: aging research comes of age by Kuroo, M

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