Search Results - "Kurlander, Roger J"

Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation by Li, Yixin, Kurlander, Roger J

“…The ability to expand virus- or tumor-specific T cells without damaging their functional capabilities is critical for success adoptive transfer immunotherapy…”
Get full text

Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques by Waldmann, Thomas A., Lugli, Enrico, Roederer, Mario, Perera, Liyanage P., Smedley, Jeremy V., Macallister, Rhonda P., Goldman, Carolyn K., Bryant, Bonita R., Decker, Jean M., Fleisher, Thomas A., Lane, H. Clifford, Sneller, Michael C., Kurlander, Roger J., Kleiner, David E., Pletcher, John M., Figg, William D., Yovandich, Jason L., Creekmore, Stephen P.

“…IL-15 uses the heterotrimeric receptor IL-2/IL-15Rβ and the γ chain shared with IL-2 and the cytokine-specific IL-15Rα. Although IL-15 shares actions with IL-2…”
Get full text

Scavenger receptor-BI is a receptor for lipoprotein(a) by Yang, Xiao-Ping, Amar, Marcelo J., Vaisman, Boris, Bocharov, Alexander V., Vishnyakova, Tatyana G., Freeman, Lita A., Kurlander, Roger J., Patterson, Amy P., Becker, Lewis C., Remaley, Alan T.

“…Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low…”
Get full text

A functional comparison of mature human dendritic cells prepared in fluorinated ethylene-propylene bags or polystyrene flasks by Kurlander, Roger J., Tawab, Abdul, Fan, Yong, Carter, Charles S., Read, Elizabeth J.

“…BACKGROUND: Fluorinated ethylene‐propylene (FEP) bags have been used instead of polystyrene (PS) flasks for ex vivo clinical‐scale production of human…”
Get full text

Aberrant Levels of miRNAs in Bone Marrow Microenvironment and Peripheral Blood of Myeloma Patients and Disease Progression by Wang, Weixin, Corrigan-Cummins, Meghan, Barber, Emily A, Saleh, Layla M, Zingone, Adriana, Ghafoor, Azam, Costello, Rene, Zhang, Yong, Kurlander, Roger J, Korde, Neha, Roccaro, Aldo M, Ghobrial, Irene M, Landgren, Ola, Calvo, Katherine R

“…The bone marrow (BM) microenvironment of multiple myeloma (MM) is reported to play a role in the biology of disease. In this study, we found that the…”
Get full text

Effect of ex vivo culture duration on phenotype and cytokine production by mature dendritic cells derived from peripheral blood monocytes by Tawab, Abdul, Fan, Yong, Read, Elizabeth J., Kurlander, Roger J.

“…BACKGROUND: To generate clinical‐grade dendritic cells (DCs) ex vivo for immunotherapy trials, peripheral blood monocytes are typically cultured in…”
Get full text

Hypermutation of ApoB mRNA by Rat APOBEC-1 Overexpression Mimics APOBEC-3 Hypermutation by Chen, Zhigang, Eggerman, Thomas L., Bocharov, Alexander V., Baranova, Irina N., Vishnyakova, Tatyana G., Kurlander, Roger J., Csako, Gyorgy, Patterson, Amy P.

“…APOBEC-3 proteins induce C-to-U hypermutations in the viral genome of various viruses and have broad antiviral activity. Generally, only a small proportion of…”
Get full text

Costimulated tumor-infiltrating lymphocytes are a feasible and safe alternative donor cell therapy for relapse after allogeneic stem cell transplantation by Hardy, Nancy M., Fellowes, Vicki, Rose, Jeremy J., Odom, Jeanne, Pittaluga, Stefania, Steinberg, Seth M., Blacklock-Schuver, Bazetta, Avila, Daniele N., Memon, Sarfraz, Kurlander, Roger J., Khuu, Hahn M., Stetler-Stevenson, Maryalice, Mena, Esther, Dwyer, Andrew J., Levine, Bruce L., June, Carl H., Reshef, Ran, Vonderheide, Robert H., Gress, Ronald E., Fowler, Daniel H., Hakim, Frances T., Bishop, Michael R.

“…Donor lymphocyte infusion (DLI), a standard relapse treatment after allogeneic stem cell transplantation (AlloSCT), has limited efficacy and often triggers…”
Get full text

Recombinant lemA without adjuvant induces extensive expansion of H2-M3-restricted CD8 effectors, which can suppress primary listeriosis in mice by Tawab, Abdul, Fields, Janet, Chao, Elizabeth, Kurlander, Roger J.

“…Mice infected with Listeria monocytogenes (LM) produce large numbers of H2-M3-restricted CD8 T cells directed against the formylated peptides, f-MIGWII and…”
Get full text

Specialized Role for a Murine Class I-b MHC Molecule in Prokaryotic Host Defenses by Kurlander, Roger J., Shawar, Said M., Brown, Melinda L., Rich, Robert R.

“…Although nonclassical (class l-b) gene products represent the majority of murine major histocompatibility complex (MHC) genes, the role of these relatively…”
Get full text

The Adjacent Flanking Region Plays a Critical Role in Facilitating the Presentation of the Listeria monocytogenes Product lemA to H2 M3wt-Restricted, Peptide-Specific Murine CD8 Cells by Kurlander, Roger J, Chao, Elizabeth, Fields, Janet, Nataraj, Chandrasekaran

“…Mice infected with Listeria monocytogenes (LM) generate CD8 effectors specific for f-MIGWII, the amino terminus of the bacterial product lemA presented by the…”
Get full text

Hypermutation of apoB mRNA by rat APOBEC-1 over-expression mimicks APOBEC-3 hypermutation by Chen, Zhigang, Eggerman, Thomas L., Bocharov, Alexander V., Baranova, Irina N., Vishnyakova, Tatyana G., Kurlander, Roger J., Csako, Gyorgy, Patterson, Amy P.

“…APOBEC-3 proteins induce C-to-U hypermutations in the viral genome of various viruses and have broad antiviral activity. Generally only a small proportion of…”
Get full text

In Chronic Myeloid Leukemia Cytotoxic T Cell Responses to BMI-1 Protein Correlate with Higher Expression of BMI-1 in Leukemia Progenitors, and May Contribute to Improved Outcome After Allogeneic Stem Cell Transplantation by Yong, S. M. Agnes, Stephens, Nicole, Savani, Bipin N., Li, Yixin, Eniafe, Rhoda, Keyvanfar, Keyvan, Kurlander, Roger J, Rezvani, Katayoun, Barrett, A. John

“…Abstract 192▪▪This icon denotes an abstract that is clinically relevant. The polycomb group (PcG) proteins BMI-1 and EZH2 are key regulators of self-renewal…”
Get full text

The Response to Repeated Vaccination with PR1 and WT1 Peptides Admixed in Montanide Adjuvant Is Transient and Fails to Induce Sustained Anti-Leukemia Responses in Patients with Myeloid Malignancies by Rezvani, Katayoun, Yong, Agnes S.M., Mielke, Stephan, Jafarpour, Behnam, Savani, Bipin N., Le, Quan, Eniafe, Rhoda, Boss, Carol, Kurlander, Roger J, Barrett, A. John

“…Abstract 4096 Poster Board III-1031 We previously demonstrated the immunogenicity of a combined vaccine approach employing two leukemia-associated antigenic…”
Get full text

Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-α by Halpern, Melissa D., Kurlander, Roger J., Pisetsky, David S.

“…Bacterial, but not mammalian DNA, can induce interferon-γ (IFN-γ) in murine splenocytes. To elucidate the basis of this activity, we have assessedin…”
Get full text

Prolonging the Incubation of Monocytes with GM-CSF and IL-4 for More Than 3 Days during the Generation of Dendritic Cells (DCS) In Vitro Markedly Diminishes IL-12 and Increases IL-10 Production When DCS Are Subsequently Matured by Tawab, Abdul, Fan, Yong, Mai, Thao, Read, Elizabeth J., Kurlander, Roger J.

“…Dendritic cells (DCs) are potent antigen presenting cells with therapeutic potential in stimulating host T cell responses against cancer and microbial…”
Get full text

Cultured Human B Cell APCs Expanded Using Il-4 and CD40 Ligand Preferentially Promote a Type 2 T Cell Response to Alloimmune Stimulation by Tawab, Abdul, Takahashi, Yoshiyuki, Richard, Childs, Roger, Kurlander J.

“…In vitro stimulation of human peripheral blood B cells with recombinant IL-4 and CD40 ligand (CD40L) markedly increases their expression of MHC and…”
Get full text

Analysis of the Interrelationship between IL-12, TNF-α, and IFN-γ/Production during Murine Listeriosis by Liu, Wet, Kurlander, Roger J.

“…IL-12, a recently described cytokine, is an important mediator in the early production of IFN-γ during infection. To evaluate the timing of IL-12 production,…”
Get full text

H2M3wt-restricted, Listeria monocytogenesimmune CD8 T cells respond to multiple formylated peptides and to a variety of Gram-positive and Gram-negative bacteria by Chandrasekaran Nataraj, George Russell Huffman, Kurlander, Roger J

“…A subset of H2M3wt-restricted, Listeria monocytogenes (LM)-immune CD8 effectors recognize antigen-presenting cells (APC) preincubated with heat-killed LM. The…”
Get full text

Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts by Mannon, R B, Kotzin, B L, Nataraj, C, Ferri, K, Roper, E, Kurlander, R J, Coffman, T M

“…Allospecific CD8(+) T lymphocytes are an important component of the cellular response in allograft rejection. These cells recognize and engage MHC class I…”
Get full text