Search Results - "Kurkinen, M."

Silent brain infarcts, leukoaraiosis, and long-term prognosis in young ischemic stroke patients by PUTAALA, J, HAAPANIEMI, E, KURKINEN, M, SALONEN, O, KASTE, M, TATLISUMAK, T

“…To investigate prognostic relevance of silent brain infarcts (SBIs) and leukoaraiosis (LA) in young patients with ischemic stroke. This observational cohort…”
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Silent brain infarcts and leukoaraiosis in young adults with first-ever ischemic stroke by PUTAALA, J, KURKINEN, M, TARVOS, V, SALONEN, O, KASTE, M, TATLISUMAK, T

“…We recently observed that 13% of 1,008 consecutive adults aged 15-49 years with first-ever ischemic stroke had one or more silent brain infarcts (SBIs), and…”
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Alzheimer's Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation by Viswanathan, Jayashree, Haapasalo, Annakaisa, Böttcher, Claudia, Miettinen, Riitta, Kurkinen, Kaisa M.A, Lu, Alice, Thomas, Anne, Maynard, Christa J, Romano, Donna, Hyman, Bradley T, Berezovska, Oksana, Bertram, Lars, Soininen, Hilkka, Dantuma, Nico P, Tanzi, Rudolph E, Hiltunen, Mikko

“…The Alzheimer's disease (AD)-associated ubiquilin-1 regulates proteasomal degradation of proteins, including presenilin (PS). PS-dependent γ-secretase…”
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Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models by Martiskainen, Henna, Viswanathan, Jayashree, Nykänen, Niko-Petteri, Kurki, Mitja, Helisalmi, Seppo, Natunen, Teemu, Sarajärvi, Timo, Kurkinen, Kaisa M.A, Pursiheimo, Juha-Pekka, Rauramaa, Tuomas, Alafuzoff, Irina, Jääskeläinen, Juha E, Leinonen, Ville, Soininen, Hilkka, Haapasalo, Annakaisa, Huttunen, Henri J, Hiltunen, Mikko

“…Abstract In this study, we have assessed the expression and splicing status of genes involved in the pathogenesis or affecting the risk of Alzheimer's disease…”
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Ubiquilin‑1 Modulates γ‑Secretase-Mediated ε‑Site Cleavage in Neuronal Cells by Viswanathan, Jayashree, Haapasalo, Annakaisa, Kurkinen, Kaisa M. A, Natunen, Teemu, Mäkinen, Petra, Bertram, Lars, Soininen, Hilkka, Tanzi, Rudolph E, Hiltunen, Mikko

“…Ubiquilin-1 is an Alzheimer’s disease-associated protein, which is known to modulate amyloid precursor protein (APP) processing, amyloid-β (Aβ) secretion, and…”
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Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease by Martiskainen, Henna, Haapasalo, Annakaisa, Kurkinen, Kaisa M A, Pihlajamäki, Jussi, Soininen, Hilkka, Hiltunen, Mikko

“…Progressive neuronal loss is a key feature in Alzheimer's disease (AD), which is the most common neurodegenerative disorder in the aging population. Currently,…”
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High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status by Takalo, Mari, Haapasalo, Annakaisa, Martiskainen, Henna, Kurkinen, Kaisa M.A., Koivisto, Henna, Miettinen, Pasi, Khandelwal, Vinoth K.M., Kemppainen, Susanna, Kaminska, Dorota, Mäkinen, Petra, Leinonen, Ville, Pihlajamäki, Jussi, Soininen, Hilkka, Laakso, Markku, Tanila, Heikki, Hiltunen, Mikko

“…Alzheimer’s disease and type 2 diabetes mellitus are risk factors for each other. To investigate the effects of both genetic and high-fat-induced diabetic…”
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Heterogeneity of cell death by Stevens, J B, Abdallah, B Y, Liu, G, Horne, S D, Bremer, S W, Ye, K J, Huang, J Y, Kurkinen, M, Ye, C J, Heng, H H Q

“…Cell death constitutes a number of heterogeneous processes. Despite the dynamic nature of cell death, studies of cell death have primarily focused on…”
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Vaginal Clindamycin in Preventing Preterm Birth and Peripartal Infections in Asymptomatic Women With Bacterial Vaginosis: A Randomized, Controlled Trial by KEKKI, M., KURKI, T., PELKONEN, J., KURKINEN-RÄTY, M., CACCIATORE, B., PAAVONEN, J.

“…OBJECTIVETo determine whether treatment of bacterial vaginosis (BV) in early pregnancy decreases the risk of preterm delivery and peripartum infectious…”
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Synaptic dysfunction and septin protein family members in neurodegenerative diseases by Marttinen, Mikael, Kurkinen, Kaisa Ma, Soininen, Hilkka, Haapasalo, Annakaisa, Hiltunen, Mikko

“…Cognitive decline and disease progression in different neurodegenerative diseases typically involves synaptic dysfunction preceding the neuronal loss. The…”
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A polyomavirus enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-O-tetradecanoylphorbol-13-acetate response of the human stromelysin gene by BUTTICE, G, KURKINEN, M

“…The expression of stromelysin, a major matrix metalloproteinase of connective tissues, is regulated by several cytokines, growth factors, protooncogenes as…”
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SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1 by Kurkinen, Kaisa M A, Marttinen, Mikael, Turner, Laura, Natunen, Teemu, Mäkinen, Petra, Haapalinna, Fanni, Sarajärvi, Timo, Gabbouj, Sami, Kurki, Mitja, Paananen, Jussi, Koivisto, Anne M, Rauramaa, Tuomas, Leinonen, Ville, Tanila, Heikki, Soininen, Hilkka, Lucas, Fiona R, Haapasalo, Annakaisa, Hiltunen, Mikko

“…Dysfunction and loss of synapses are early pathogenic events in Alzheimer's disease. A central step in the generation of toxic amyloid-β (Aβ) peptides is the…”
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Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach by Martiskainen, Henna, Helisalmi, Seppo, Viswanathan, Jayashree, Kurki, Mitja, Hall, Anette, Herukka, Sanna-Kaisa, Sarajärvi, Timo, Natunen, Teemu, Kurkinen, Kaisa M A, Huovinen, Jaakko, Mäkinen, Petra, Laitinen, Marjo, Koivisto, Anne M, Mattila, Kari M, Lehtimäki, Terho, Remes, Anne M, Leinonen, Ville, Haapasalo, Annakaisa, Soininen, Hilkka, Hiltunen, Mikko

“…Several risk loci for Alzheimer's disease (AD) have been identified during recent years in large-scale genome-wide association studies. However, little is…”
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Promoter elements in the transcriptional activation of the human stromelysin-1 gene by the inflammatory cytokine, interleukin 1 by GUINONES, S, BUTTICE, G, KURKINEN, M

“…Stromelysin-1, a tissue-remodelling metalloproteinase synthesized by fibroblasts, has proteolytic activity against a variety of extracellular matrix…”
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Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models by Natunen, Teemu, Takalo, Mari, Kemppainen, Susanna, Leskelä, Stina, Marttinen, Mikael, Kurkinen, Kaisa M.A, Pursiheimo, Juha-Pekka, Sarajärvi, Timo, Viswanathan, Jayashree, Gabbouj, Sami, Solje, Eino, Tahvanainen, Eveliina, Pirttimäki, Tiina, Kurki, Mitja, Paananen, Jussi, Rauramaa, Tuomas, Miettinen, Pasi, Mäkinen, Petra, Leinonen, Ville, Soininen, Hilkka, Airenne, Kari, Tanzi, Rudolph E, Tanila, Heikki, Haapasalo, Annakaisa, Hiltunen, Mikko

“…Abstract Accumulation of β-amyloid (Aβ) and phosphorylated tau in the brain are central events underlying Alzheimer's disease (AD) pathogenesis. Aβ is…”
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The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin by Saus, J, Quinones, S, Otani, Y, Nagase, H, Harris, E D, Kurkinen, M

“…We have determined the complete primary structure for human matrix metalloproteinase-3 (MMP-3), which has 477 residues including a 17-residue signal peptide…”
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Changing incidence and outcome of infants with respiratory distress syndrome in the 1990s: a population-based survey by Koivisto, M, Marttila, R, Kurkinen-Räty, M, Saarela, T, Pokela, M-L, Jouppila, P, Hallman, M

“…Aim: To evaluate the trends in the incidence, clinical course and outcome of respiratory distress syndrome (RDS) in the newborn in the Oulu University Hospital…”
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Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease by Natunen, Teemu, Parrado, Antonio R, Helisalmi, Seppo, Pursiheimo, Juha-Pekka, Sarajärvi, Timo, Mäkinen, Petra, Kurkinen, Kaisa M A, Mullin, Kristina, Alafuzoff, Irina, Haapasalo, Annakaisa, Bertram, Lars, Soininen, Hilkka, Tanzi, Rudolph E, Hiltunen, Mikko

“…Golgi-localized γ-ear-containing ADP-ribosylation factor-binding protein (GGA3) is a central regulator of trafficking and degradation of BACE1 (β-site…”
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Transcriptional regulation of human stromelysin by Quinones, S, Saus, J, Otani, Y, Harris, E D, Kurkinen, M

“…We have determined that human stromelysin mRNA can be induced by interleukin-1β (IL-1β) and that the induced mRNA levels can be suppressed by retinoic acid and…”
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The complete primary structure for the alpha 1-chain of mouse collagen IV. Differential evolution of collagen IV domains by Muthukumaran, G, Blumberg, B, Kurkinen, M

“…We report here the complete nucleotide and amino acid sequences for the alpha 1-chain of mouse collagen IV which is 1669 amino acids in length, including a…”
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