Search Results - "Kurkó, Dalma"

Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist by Baska, Ferenc, Bozó, Éva, Szeleczky, Zsolt, Szántó, Gábor, Vukics, Krisztina, Szakács, Zoltán, Domány-Kovács, Katalin, Kurkó, Dalma, Vass, Elemér, Thán, Márta, Vastag, Mónika, Temesvári, Krisztina, Lévai, Sándor, Halász, Attila Sándor, Szondiné Kordás, Krisztina, Román, Viktor, Greiner, István, Bata, Imre

“…The V1a receptor is a major contributor in mediating the social and emotional effects of arginine-vasopressin (AVP); therefore it represents a promising target…”
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Controlling receptor function from the extracellular vestibule of G-protein coupled receptors by Egyed, Attila, Domány-Kovács, Katalin, Koványi, Bence, Horti, Ferenc, Kurkó, Dalma, Kiss, Dóra Judit, Pándy-Szekeres, Gáspár, Greiner, István, Keserű, György M

“…Receptor function is traditionally controlled from the orthosteric binding site of G-protein coupled receptors. Here, we show that the functional activity and…”
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New V1a receptor antagonist. Part 1. Synthesis and SAR development of urea derivatives by Szántó, Gábor, Makó, Attila, Baska, Ferenc, Bozó, Éva, Domány-Kovács, Katalin, Kurkó, Dalma, Cselenyák, Attila, Mohácsi, Réka, Kordás, Krisztina Szondiné, Bata, Imre

“…[Display omitted] Solid preclinical evidence links vasopressin to social behavior in animals, so, extensive work has been initiated to find new vasopressin V1a…”
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Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine by Kiss, Béla, Némethy, Zsolt, Fazekas, Károly, Kurkó, Dalma, Gyertyán, István, Sághy, Katalin, Laszlovszky, István, Farkas, Bence, Kirschner, Norbert, Bolf-Terjéki, Etelka, Balázs, Ottilia, Lendvai, Balázs

“…Cariprazine, a dopamine D -preferring D /D receptor partial agonist and serotonin 5-HT receptor partial agonist, has two major human metabolites,…”
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GluN2B-containing NMDA receptors as possible targets for the neuroprotective and antidepressant effects of fluoxetine by Kiss, Janos P., Szasz, Bernadett K., Fodor, László, Mike, Arpad, Lenkey, Nora, Kurkó, Dalma, Nagy, József, Vizi, E. Sylvester

“…► Whole-cell patch-clamp recordings of cortical neurons and HEK 293 cells were used. ► Inhibitory effect of drugs on GluN2A-containing and GluN2B-containing…”
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Discovery of New Heterocyclic Ring Systems as Novel and Potent V 1A Receptor Antagonists by Baska, Ferenc, Szántó, Gábor, Bozó, Éva, Szakács, Zoltán, Dékány, Miklós, Szondiné Kordás, Krisztina, Domány-Kovács, Katalin, Kurkó, Dalma, Hodoscsek, Barbara, Magdó, Ildikó, Krámos, Balázs, Béni, Zoltán, Vastag, Mónika, Bata, Imre

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Discovery of New Heterocyclic Ring Systems as Novel and Potent V1A Receptor Antagonists by Baska, Ferenc, Szántó, Gábor, Bozó, Éva, Szakács, Zoltán, Dékány, Miklós, Szondiné Kordás, Krisztina, Domány-Kovács, Katalin, Kurkó, Dalma, Hodoscsek, Barbara, Magdó, Ildikó, Krámos, Balázs, Béni, Zoltán, Vastag, Mónika, Bata, Imre

“…Autism spectrum disorder is a neurodevelopmental disease with increasing occurrence. Recent studies focus on the development of novel V1A receptor antagonists…”
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The influence of 5-HT2A activity on a 5-HT2C specific in vivo assay used for early identification of multiple acting SERT and 5-HT2C receptor ligands by Éliás, Olivér, Nógrádi, Katalin, Domány, György, Szakács, Zoltán, Kóti, János, Szántay, Csaba, Tarcsay, Ákos, Keserű, György M., Gere, Anikó, Kiss, Béla, Kurkó, Dalma, Kolok, Sándor, Némethy, Zsolt, Kapui, Zoltán, Hellinger, Éva, Vastag, Mónika, Sághy, Katalin, Kedves, Rita, Gyertyán, István

“…[Display omitted] As a result of our exploratory programme aimed at elaborating dually acting compounds towards the serotonin (5-HT) transporter (SERT) and the…”
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Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs by Wágner, Gábor, Wéber, Csaba, Nyéki, Olga, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György

“…Here we report the discovery and early SAR of a series of mGluR5 negative allosteric modulators (NAMs). Starting from a moderately active HTS hit we…”
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Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists by Galambos, János, Wágner, Gábor, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Gyertyán, István, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György

“…Hit-to-lead optimization of a HTS hit led to new carbamoyloxime derivatives. After identification of an advanced hit (8d) the CYP enzyme inhibitory activity of…”
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New V1a receptor antagonist. Part 2. Identification and optimization of triazolobenzazepines by Bozó, Éva, Baska, Ferenc, Lövei, Klára, Szántó, Gábor, Domány-Kovács, Katalin, Kurkó, Dalma, Szondiné Kordás, Krisztina, Szokoli, Teodóra, Bata, Imre

“…[Display omitted] Solid preclinical evidence links vasopressin to social behavior in animals, so, extensive work has been initiated to find new vasopressin V1a…”
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Cell-based and virtual fragment screening for adrenergic α2C receptor agonists by Szőllősi, Edit, Bobok, Amrita, Kiss, László, Vass, Márton, Kurkó, Dalma, Kolok, Sándor, Visegrády, András, Keserű, György M.

“…[Display omitted] Fragment-based drug discovery has emerged as an alternative to conventional lead identification and optimization strategies generally…”
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The influence of 5-HT 2A activity on a 5-HT 2C specific in vivo assay used for early identification of multiple acting SERT and 5-HT 2C receptor ligands by Éliás, Olivér, Nógrádi, Katalin, Domány, György, Szakács, Zoltán, Kóti, János, Szántay, Csaba, Tarcsay, Ákos, Keserű, György M., Gere, Anikó, Kiss, Béla, Kurkó, Dalma, Kolok, Sándor, Némethy, Zsolt, Kapui, Zoltán, Hellinger, Éva, Vastag, Mónika, Sághy, Katalin, Kedves, Rita, Gyertyán, István

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Inducible expression and pharmacological characterization of recombinant rat NR1a/NR2A NMDA receptors by Kurkó, Dalma, Dezső, Péter, Boros, András, Kolok, Sándor, Fodor, László, Nagy, József, Szombathelyi, Zsolt

“…In this study, we have established a non-neuronal cell line stably and inducibly expressing recombinant NMDA receptors (NRs) composed of rat NR1a/NR2A…”
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Corrigendum to “Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs” [Bioorg. Med. Chem. Lett. 20 (2010) 3737–3741] by Wágner, Gábor, Wéber, Csaba, Nyéki, Olga, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György

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The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands by Éliás, Olivér, Nógrádi, Katalin, Domány, György, Szakács, Zoltán, Kóti, János, Szántay, Jr, Csaba, Tarcsay, Ákos, Keserű, György M, Gere, Anikó, Kiss, Béla, Kurkó, Dalma, Kolok, Sándor, Némethy, Zsolt, Kapui, Zoltán, Hellinger, Éva, Vastag, Mónika, Sághy, Katalin, Kedves, Rita, Gyertyán, István

“…As a result of our exploratory programme aimed at elaborating dually acting compounds towards the serotonin (5-HT) transporter (SERT) and the 5-HT2C receptor a…”
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Analysis of functional selectivity through G protein-dependent and -independent signaling pathways at the adrenergic α2C receptor by Kurko, Dalma, Kapui, Zoltán, Nagy, József, Lendvai, Balázs, Kolok, Sándor

“…Highlights • Comparative pharmacology of four α2C -AR related signaling pathways was carried out. • We quantify the level of biased signaling by applying an…”
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Analysis of functional selectivity through G protein-dependent and -independent signaling pathways at the adrenergic alpha 2C receptor by Kurko, Dalma, Kapui, Zoltan, Nagy, Jozsef, Lendvai, Balazs, Kolok, Sandor

“…Although G protein-coupled receptors (GPCRs) are traditionally categorized as Gs-, Gq-, or Gi/o-coupled, their signaling is regulated by multiple mechanisms…”
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Analysis of functional selectivity through G protein-dependent and -independent signaling pathways at the adrenergic α(2C) receptor by Kurko, Dalma, Kapui, Zoltán, Nagy, József, Lendvai, Balázs, Kolok, Sándor

“…Although G protein-coupled receptors (GPCRs) are traditionally categorized as Gs-, Gq-, or Gi/o-coupled, their signaling is regulated by multiple mechanisms…”
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The influence of 5-HT sub(2A) activity on a 5-HT sub(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT sub(2C) receptor ligands by Elias, Oliver, Nogradi, Katalin, Domany, Gyorgy, Szakacs, Zoltan, Koti, Janos, Szantay, Csaba Jr, Tarcsay, Akos, Keserue, Gyorgy M, Gere, Aniko, Kiss, Bela, Kurko, Dalma, Kolok, Sandor, Nemethy, Zsolt, Kapui, Zoltan, Hellinger, Eva, Vastag, Monika, Saghy, Katalin, Kedves, Rita, Gyertyan, Istvan

“…As a result of our exploratory programme aimed at elaborating dually acting compounds towards the serotonin (5-HT) transporter (SERT) and the 5-HT sub(2C)…”
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