Search Results - "Kurita, Kenji L."

Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries by Kurita, Kenji L., Glassey, Emerson, Linington, Roger G.

“…Traditional natural products discovery using a combination of live/dead screening followed by iterative bioassay-guided fractionation affords no information…”
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Connecting Phenotype and Chemotype: High-Content Discovery Strategies for Natural Products Research by Kurita, Kenji L, Linington, Roger G

“…In recent years, the field of natural products has seen an explosion in the breadth, resolution, and accuracy of profiling platforms for compound discovery,…”
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High-Throughput, Nondestructive, and Biosafe Method to Accurately Quantify Water Content in Human Fecal Samples by Benchtop 1H TD-NMR Analysis for Downstream Bioanalytical and Clinical Uses by Sangaraju, Dewakar, Nott, Kevin P, Kurita, Kenji L

“…Water or moisture content in human stool samples is an important parameter for bioanalytical and clinical purposes. For bioanalytical use, accurate…”
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Middle-out sequence confirmation of CRISPR/Cas9 single guide RNA (sgRNA) using DNA primers and ribonuclease T1 digestion by Chin, Steven, Goyon, Alexandre, Zhang, Kelly, Kurita, Kenji L.

“…Accurate sequencing of single guide RNAs (sgRNAs) for CRISPR/Cas9 genome editing is critical for patient safety, as the sgRNA guides the Cas9 nuclease to…”
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Seeking universal detectors for analytical characterizations by Zhang, Kelly, Kurita, Kenji L., Venkatramani, Cadapakam, Russell, David

“…•Universal detectors that can detect all types of compounds and give uniform response are highly desirable.•Reviewed commonly used detectors in analytical…”
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Ultraviolet photodissociation facilitates mass spectrometry-based structure elucidation with pyrrolidine and piperidine containing compounds by Chen, Bifan, Kurita, Kenji L., Wong, Nicholas, Crittenden, Christopher M.

“…In pharmaceutical development, structural elucidation of small molecules from process related impurities and degradation products is an essential component. As…”
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Two-dimensional reversed phase-normal phase liquid chromatography for simultaneous achiral-chiral analysis to support high-throughput experimentation by Chin, Steven, Cruz, Karissa, Goyon, Alexandre, Venkatramani, Cadapakam J., Yehl, Peter M., Kurita, Kenji L.

“…•Development of a RPLCNPLC two-dimensional liquid chromatography system.•Simultaneous achiral-chiral analysis to support high-throughput…”
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Investigating the Origin of Epimerization Attenuation during Pd-Catalyzed Cross-Coupling Reactions by Cai, Isabelle, Malig, Thomas C., Kurita, Kenji L., Derasp, Joshua S., Sirois, Lauren E., Hein, Jason E.

“…Palladium-catalyzed cross-couplings remain among the most robust methodologies to form carbon–carbon and carbon-heteroatom bonds. In particular,…”
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A reliable external calibration method for reaction monitoring with benchtop NMR by Maschmeyer, Tristan, Conklin, Breanna, Malig, Thomas C., Russell, David J., Kurita, Kenji L., Hein, Jason E., Napolitano, José G.

“…Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical technique with the ability to acquire both quantitative and structurally insightful data…”
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Synthetic Studies Toward the Skyllamycins: Total Synthesis and Generation of Simplified Analogues by Giltrap, Andrew M, Haeckl, F. P. Jake, Kurita, Kenji L, Linington, Roger G, Payne, Richard J

“…Herein, we report our synthetic studies toward the skyllamycins, a highly modified class of nonribosomal peptide natural products which contain a number of…”
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High-throughput functional annotation of natural products by integrated activity profiling by Hight, Suzie K, Clark, Trevor N, Kurita, Kenji L, McMillan, Elizabeth A, Bray, Walter, Shaikh, Anam F, Khadilkar, Aswad, Haeckl, F P Jake, Carnevale-Neto, Fausto, La, Scott, Lohith, Akshar, Vaden, Rachel M, Lee, Jeon, Wei, Shuguang, Lokey, R Scott, White, Michael A, Linington, Roger G, MacMillan, John B

“…Determining mechanism of action (MOA) is one of the biggest challenges in natural products discovery. Here, we report a comprehensive platform that uses…”
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Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure–activity relationship of anabaenopeptin protease inhibitors by Harms, Henrik, Kurita, Kenji L., Pan, Li, Wahome, Paul G., He, Haiyin, Kinghorn, A. Douglas, Carter, Guy T., Linington, Roger G.

“…[Display omitted] Cyanobacteria possess a unique capacity for the production of structurally novel secondary metabolites compared to the biosynthetic abilities…”
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Total Synthesis of SkyllamycinsA-C by Giltrap, Andrew M, Haeckl, F P Jake, Kurita, Kenji L, Linington, Roger G, Payne, Richard J

“…The skyllamycins are a family of highly functionalized non-ribosomal cyclic depsipeptide natural products which contain the extremely rare [alpha]-OH-glycine…”
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Total Synthesis of Skyllamycins A–C by Giltrap, Andrew M., Haeckl, F. P. Jake, Kurita, Kenji L., Linington, Roger G., Payne, Richard J.

“…The skyllamycins are a family of highly functionalized non‐ribosomal cyclic depsipeptide natural products which contain the extremely rare α‐OH‐glycine…”
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Maculatic Acids—Sex Attractant Pheromone Components of Bald‐Faced Hornets by Ren, Weiwu, Gries, Regine, McCaughey, Catherine, Derstine, Nathan, Alamsetti, Santosh K., Kurita, Kenji L., Tu, Lorna, Linington, Roger G., Britton, Robert, Gries, Gerhard

“…Yellowjackets in the genera Vespula and Dolichovespula are prevalent eusocial insects of great ecological and economic significance, but the chemical signals…”
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Isolation, Structure Elucidation, and Total Synthesis of Dolichovespulide, a Sesquiterpene from Dolichovespula Yellowjackets by Ren, Weiwu, Gries, Regine, Kurita, Kenji L, McCaughey, Catherine S, Alamsetti, Santosh K, Linington, Roger G, Gries, Gerhard, Britton, Robert

“…As part of an ongoing program to identify sex attractant pheromone components that mediate sexual communication in yellowjacket wasps, a novel sesquiterpene…”
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A selective genome-guided method for environmental Burkholderia isolation by Haeckl, F. P. Jake, Baldim, João L., Iskakova, Dasha, Kurita, Kenji L., Soares, Marisi G., Linington, Roger G.

“…The genus Burkholderia is an emerging source of novel natural products chemistry, yet to date few methods exist for the selective isolation of strains of this…”
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Versatile Method for the Detection of Covalently Bound Substrates on Solid Supports by DART Mass Spectrometry by Sanchez, Laura M, Curtis, Matthew E, Bracamonte, Bianca E, Kurita, Kenji L, Navarro, Gabriel, Sparkman, O. David, Linington, Roger G

“…Analysis of substrates directly on solid phase resins without the need for separate cleavage conditions remains an outstanding challenge in the field of solid…”
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Titelbild: Maculatic Acids—Sex Attractant Pheromone Components of Bald‐Faced Hornets (Angew. Chem. 36/2018) by Ren, Weiwu, Gries, Regine, McCaughey, Catherine, Derstine, Nathan, Alamsetti, Santosh K., Kurita, Kenji L., Tu, Lorna, Linington, Roger G., Britton, Robert, Gries, Gerhard

“…Langkopfwespen bauen riesige Nester, die von Arbeiterinnen unterhalten werden. Im Spätsommer ziehen sie junge Königinnen auf, die Maculatinsäuren als…”
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Maculatic Acids—Sex Attractant Pheromone Components of Bald‐Faced Hornets by Ren, Weiwu, Gries, Regine, McCaughey, Catherine, Derstine, Nathan, Alamsetti, Santosh K., Kurita, Kenji L., Tu, Lorna, Linington, Roger G., Britton, Robert, Gries, Gerhard

“…Yellowjackets in the genera Vespula and Dolichovespula are prevalent eusocial insects of great ecological and economic significance, but the chemical signals…”
Get full text