Sleep deprivation induces late deleterious effects in a pharmacological model of Parkinsonism

Parkinson’s disease is a degenerative, chronic and progressive disease, characterized by motor dysfunctions. Patients also exhibit non-motor symptoms, such as affective and sleep disorders. Sleep disorders can potentiate clinical and neuropathological features and lead to worse prognosis. The goal o...

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Bibliographic Details
Published in:	Experimental brain research Vol. 242; no. 5; pp. 1175 - 1190
Main Authors:	Lopes-Silva, L. B., Cunha, D. M. G., Lima, A. C., Bioni, V. S., Gonçalves, N., Kurita, J. P. F., Wuo-Silva, R., Silva, R. H.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-05-2024 Springer Nature B.V
Subjects:	Anhedonia - drug effects Anhedonia - physiology Animals Basal ganglia Biomedical and Life Sciences Biomedicine Catalepsy Catalepsy - chemically induced Central nervous system diseases Cognitive ability Disease Models, Animal Immunoreactivity Locomotion Male Mice Motor Activity - drug effects Motor Activity - physiology Movement disorders Neurodegenerative diseases Neurology Neurosciences Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - physiopathology Pattern recognition Recognition, Psychology - drug effects Recognition, Psychology - physiology Research Article Reserpine Reserpine - pharmacology Sleep deprivation Sleep Deprivation - complications Sleep disorders Substantia nigra Tyrosine 3-monooxygenase Tyrosine 3-Monooxygenase - metabolism Animal model Sleep Parkinson’s disease Reserpine Sleep deprivation
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Summary:	Parkinson’s disease is a degenerative, chronic and progressive disease, characterized by motor dysfunctions. Patients also exhibit non-motor symptoms, such as affective and sleep disorders. Sleep disorders can potentiate clinical and neuropathological features and lead to worse prognosis. The goal of this study was to evaluate the effects of sleep deprivation (SD) in mice submitted to a progressive pharmacological model of Parkinsonism (chronic administration with a low dose of reserpine). Male Swiss mice received 20 injections of reserpine (0.1 mg/kg) or vehicle, on alternate days. SD was applied before or during reserpine treatment and was performed by gentle handling for 6 h per day for 10 consecutive days. Animals were submitted to motor and non-motor behavioral assessments and neurochemical evaluations. Locomotion was increased by SD and decreased by reserpine treatment. SD during treatment delayed the onset of catalepsy, but SD prior to treatment potentiated reserpine-induced catalepsy. Thus, although SD induced an apparent beneficial effect on motor parameters, a delayed deleterious effect on alterations induced by reserpine was found. In the object recognition test, both SD and reserpine treatment produced cognitive deficits. In addition, the association between SD and reserpine induced anhedonic-like behavior. Finally, an increase in oxidative stress was found in hippocampus of mice subjected to SD, and tyrosine hydroxylase immunoreactivity was reduced in substantia nigra of reserpine-treated animals. Results point to a possible late effect of SD, aggravating the deficits in mice submitted to the reserpine progressive model of PD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0014-4819 1432-1106 1432-1106
DOI:	10.1007/s00221-024-06811-0