Search Results - "Kurioka, Ayako"

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality by Hinks, Timothy S.C., Marchi, Emanuele, Jabeen, Maisha, Olshansky, Moshe, Kurioka, Ayako, Pediongco, Troi J., Meehan, Bronwyn S., Kostenko, Lyudmila, Turner, Stephen J., Corbett, Alexandra J., Chen, Zhenjun, Klenerman, Paul, McCluskey, James

“…Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing…”
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Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1 by Jeffery, Hannah C, van Wilgenburg, Bonnie, Kurioka, Ayako, Parekh, Krishan, Stirling, Kathryn, Roberts, Sheree, Dutton, Emma E, Hunter, Stuart, Geh, Daniel, Braitch, Manjit K, Rajanayagam, Jeremy, Iqbal, Tariq, Pinkney, Thomas, Brown, Rachel, Withers, David R, Adams, David H, Klenerman, Paul, Oo, Ye H

“…Background & Aims Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells characterised by the invariant TCR-chain, Vα7.2-Jα33, and are restricted…”
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MAIT cells: new guardians of the liver by Kurioka, Ayako, Walker, Lucy J, Klenerman, Paul, Willberg, Christian B

“…The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non‐self food and…”
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Early and nonreversible decrease of CD161++/MAIT cells in HIV infection by Cosgrove, Cormac, Ussher, James E., Rauch, Andri, Gärtner, Kathleen, Kurioka, Ayako, Hühn, Michael H., Adelmann, Krista, Kang, Yu-Hoi, Fergusson, Joannah R., Simmonds, Peter, Goulder, Philip, Hansen, Ted H., Fox, Julie, Günthard, Huldrych F., Khanna, Nina, Powrie, Fiona, Steel, Alan, Gazzard, Brian, Phillips, Rodney E., Frater, John, Uhlig, Holm, Klenerman, Paul

“…HIV infection is associated with immune dysfunction, perturbation of immune-cell subsets and opportunistic infections. CD161++CD8+ T cells are a…”
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CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages by Fergusson, Joannah R., Smith, Kira E., Fleming, Vicki M., Rajoriya, Neil, Newell, Evan W., Simmons, Ruth, Marchi, Emanuele, Björkander, Sophia, Kang, Yu-Hoi, Swadling, Leo, Kurioka, Ayako, Sahgal, Natasha, Lockstone, Helen, Baban, Dilair, Freeman, Gordon J., Sverremark-Ekström, Eva, Davis, Mark M., Davenport, Miles P., Venturi, Vanessa, Ussher, James E., Willberg, Christian B., Klenerman, Paul

“…The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant…”
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Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets by Kurioka, Ayako, Jahun, Aminu S, Hannaway, Rachel F, Walker, Lucy J, Fergusson, Joannah R, Sverremark-Ekström, Eva, Corbett, Alexandra J, Ussher, James E, Willberg, Christian B, Klenerman, Paul

“…Human mucosal-associated invariant T (MAIT) cells are an important T cell subset that are enriched in tissues and possess potent effector functions. Typically…”
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Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species by Colloca, Stefano, Barnes, Eleanor, Folgori, Antonella, Ammendola, Virginia, Capone, Stefania, Cirillo, Agostino, Siani, Loredana, Naddeo, Mariarosaria, Grazioli, Fabiana, Esposito, Maria Luisa, Ambrosio, Maria, Sparacino, Angela, Bartiromo, Marta, Meola, Annalisa, Smith, Kira, Kurioka, Ayako, O'Hara, Geraldine A, Ewer, Katie J, Anagnostou, Nicholas, Bliss, Carly, Hill, Adrian V S, Traboni, Cinzia, Klenerman, Paul, Cortese, Riccardo, Nicosia, Alfredo

“…Replication-defective adenovirus vectors based on human serotype 5 (Ad5) induce protective immune responses against diverse pathogens and cancer in animal…”
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Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function by Pace, Matthew, Williams, James, Kurioka, Ayako, Gerry, Andrew B, Jakobsen, Bent, Klenerman, Paul, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Frater, John

“…In the search for a cure for HIV-1 infection, histone deacetylase inhibitors (HDACi) are being investigated as activators of latently infected CD4 T cells to…”
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Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Salmonella Serovars by Valero-Pacheco, Nuriban, Blight, Joshua, Aldapa-Vega, Gustavo, Kemlo, Phillip, Pérez-Toledo, Marisol, Wong-Baeza, Isabel, Kurioka, Ayako, Perez-Shibayama, Christian, Gil-Cruz, Cristina, Sánchez-Torres, Luvia E, Pastelin-Palacios, Rodolfo, Isibasi, Armando, Reyes-Sandoval, Arturo, Klenerman, Paul, López-Macías, Constantino

“…infections remain a challenging health issue, causing significant morbidity and mortality worldwide. Current vaccines against typhoid fever display moderate…”
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Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging by Kurioka, Ayako, Klenerman, Paul

“…Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and Mucosal Associated Invariant T (MAIT) cells, which are…”
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Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdum by Young, Rosanna, Taylor, Jesse E, Kurioka, Ayako, Becker, Marion, Louis, Edward J, Rudenko, Gloria

“…African trypanosomes (including Trypanosoma brucei) are unicellular parasites which multiply in the mammalian bloodstream. T. brucei has about twenty telomeric…”
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Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency by Simoni, Yannick, Fehlings, Michael, Kløverpris, Henrik N., McGovern, Naomi, Koo, Si-Lin, Loh, Chiew Yee, Lim, Shawn, Kurioka, Ayako, Fergusson, Joannah R., Tang, Choong-Leong, Kam, Ming Hian, Dennis, Koh, Lim, Tony Kiat Hon, Fui, Alexander Chung Yaw, Hoong, Chan Weng, Chan, Jerry Kok Yen, Curotto de Lafaille, Maria, Narayanan, Sriram, Baig, Sonia, Shabeer, Muhammad, Toh, Sue-Anne Ee Shiow, Tan, Henry Kun Kiaang, Anicete, Rosslyn, Tan, Eng-Huat, Takano, Angela, Klenerman, Paul, Leslie, Alasdair, Tan, Daniel S.W., Tan, Iain Beehuat, Ginhoux, Florent, Newell, Evan W.

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Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes by Kurioka, Ayako, Klenerman, Paul, Willberg, Christian B.

“…Summary New data in the worlds of both innate‐like CD8+ T‐cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these…”
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CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner by Ussher, James E., Bilton, Matthew, Attwod, Emma, Shadwell, Jonathan, Richardson, Rachel, Lara, Catherine, Mettke, Elisabeth, Kurioka, Ayako, Hansen, Ted H., Klenerman, Paul, Willberg, Christian B.

“…CD161++CD8+ T cells represent a novel subset that is dominated in adult peripheral blood by mucosal‐associated invariant T (MAIT) cells, as defined by the…”
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Innate‐like CD 8+ T‐cells and NK cells: converging functions and phenotypes by Kurioka, Ayako, Klenerman, Paul, Willberg, Christian B.

“…Summary New data in the worlds of both innate‐like CD 8+ T‐cells and natural killer ( NK ) cells have, in parallel, clarified some of the phenotypes of these…”
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A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory by Swadling, Leo, Capone, Stefania, Antrobus, Richard D, Brown, Anthony, Richardson, Rachel, Newell, Evan W, Halliday, John, Kelly, Christabel, Bowen, Dan, Fergusson, Joannah, Kurioka, Ayako, Ammendola, Virginia, Del Sorbo, Mariarosaria, Grazioli, Fabiana, Esposito, Maria Luisa, Siani, Loredana, Traboni, Cinzia, Hill, Adrian, Colloca, Stefano, Davis, Mark, Nicosia, Alfredo, Cortese, Riccardo, Folgori, Antonella, Klenerman, Paul, Barnes, Eleanor

“…A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV infects millions of people worldwide and is a leading cause of liver…”
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Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease by Riva, Antonio, Patel, Vishal, Kurioka, Ayako, Jeffery, Hannah C, Wright, Gavin, Tarff, Sarah, Shawcross, Debbie, Ryan, Jennifer M, Evans, Alexander, Azarian, Sarah, Bajaj, Jasmohan S, Fagan, Andrew, Patel, Vinood, Mehta, Kosha, Lopez, Carlos, Simonova, Marieta, Katzarov, Krum, Hadzhiolova, Tanya, Pavlova, Slava, Wendon, Julia A, Oo, Ye Htun, Klenerman, Paul, Williams, Roger, Chokshi, Shilpa

“…Intestinal permeability with systemic distribution of bacterial products are central in the immunopathogenesis of alcoholic liver disease (ALD), yet links with…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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Shared and Distinct Phenotypes and Functions of Human CD161++ V alpha 7.2+T Cell Subsets by Kurioka, Ayako, Jahun, Aminu S., Hannaway, Rachel F., Walker, Lucy J., Fergusson, Joannah R., Sverremark-Ekström, Eva, Corbett, Alexandra J., Ussher, James E., Willberg, Christian B., Klenerman, Paul

“…Human mucosal-associated invariant T (MAIT) cells are an important T cell subset that are enriched in tissues and possess potent effector functions. Typically…”
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TLR signaling in human antigen‐presenting cells regulates MR1‐dependent activation of MAIT cells by Ussher, James E., Wilgenburg, Bonnie, Hannaway, Rachel F., Ruustal, Kerstin, Phalora, Prabhjeet, Kurioka, Ayako, Hansen, Ted H., Willberg, Christian B., Phillips, Rodney E., Klenerman, Paul

“…Mucosal‐associated invariant T (MAIT) cells are an abundant innate‐like T lymphocyte population that are enriched in liver and mucosal tissues. They are…”
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