Search Results - "Kurihara, Hidetake"

Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells by Yoshimura, Yasuhiro, Taguchi, Atsuhiro, Tanigawa, Shunsuke, Yatsuda, Junji, Kamba, Tomomi, Takahashi, Satoru, Kurihara, Hidetake, Mukoyama, Masashi, Nishinakamura, Ryuichi

“…Previous research has elucidated the signals required to induce nephron progenitor cells (NPCs) from pluripotent stem cells (PSCs), enabling the generation of…”
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Cell biology of mesangial cells: the third cell that maintains the glomerular capillary by Kurihara, Hidetake, Sakai, Tatsuo

“…The renal glomerulus consists of glomerular endothelial cells, podocytes, and mesangial cells, which cooperate with each other for glomerular filtration. We…”
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Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease by Fujita, Toshiro, Shibata, Shigeru, Nagase, Miki, Yoshida, Shigetaka, Kawarazaki, Wakako, Kurihara, Hidetake, Tanaka, Hirotoshi, Miyoshi, Jun, Takai, Yoshimi

“…Blockade of mineralocorticoid receptor has been shown to improve the clinical outcomes of proteinuric kidney diseases. However, little is known about the…”
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Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes by Tanigawa, Shunsuke, Islam, Mazharul, Sharmin, Sazia, Naganuma, Hidekazu, Yoshimura, Yasuhiro, Haque, Fahim, Era, Takumi, Nakazato, Hitoshi, Nakanishi, Koichi, Sakuma, Tetsushi, Yamamoto, Takashi, Kurihara, Hidetake, Taguchi, Atsuhiro, Nishinakamura, Ryuichi

“…Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular…”
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PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling by Hirose, Tomonori, Sugitani, Yoshinobu, Kurihara, Hidetake, Kazama, Hiromi, Kusaka, Chiho, Noda, Tetsuo, Takahashi, Hidehisa, Ohno, Shigeo

“…During brain development, neural precursor cells (NPCs) expand initially, and then switch to generating stage-specific neurons while maintaining self-renewal…”
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Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils by Nakayama, Hitoshi, Kurihara, Hidetake, Morita, Yasu S, Kinoshita, Taroh, Mauri, Laura, Prinetti, Alessandro, Sonnino, Sandro, Yokoyama, Noriko, Ogawa, Hideoki, Takamori, Kenji, Iwabuchi, Kazuhisa

“…Pathogenic mycobacteria use virulence factors, including mannose-capped lipoarabinomannan (ManLAM), to survive in host phagocytic cells, such as neutrophils…”
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The CXCL12 (SDF-1)/CXCR4 Axis Is Essential for the Development of Renal Vasculature by TAKABATAKE, Yoshitsugu, SUGIYAMA, Tatsuki, IMAI, Enyu, NAGASAWA, Takashi, RAKUGI, Hiromi, ISAKA, Yoshitaka, KOHARA, Hiroshi, MATSUSAKA, Taiji, KURIHARA, Hidetake, KONI, Pandelakis A, NAGASAWA, Yasuyuki, HAMANO, Takayuki, MATSUI, Isao, KAWADA, Noritaka

“…CXC chemokine ligand 12 (CXCL12; stromal cell-derived factor 1) is a unique homeostatic chemokine that signals through its cognate receptor, CXCR4…”
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KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections by Hara-Yokoyama, Miki, Kurihara, Hidetake, Ichinose, Shozo, Matsuda, Hironori, Ichinose, Shizuko, Kurosawa, Masaru, Tada, Norihiro, Iwahara, Chihiro, Terasawa, Kazue, Podyma-Inoue, Katarzyna A., Furukawa, Koichi, Iwabuchi, Kazuhisa

“…The arrangement of immature germ cells changes regularly and periodically along the axis of the seminiferous tubule, and is used to describe the progression of…”
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Mitochondrial Extrusion through the Cytoplasmic Vacuoles during Cell Death by Nakajima, Akihito, Kurihara, Hidetake, Yagita, Hideo, Okumura, Ko, Nakano, Hiroyasu

“…Under various conditions, noxious stimuli damage mitochondria, resulting in mitochondrial fragmentation; however, the mechanisms by which fragmented…”
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Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis by Kobayashi, Namiko, Ueno, Toshiharu, Ohashi, Kumi, Yamashita, Hanako, Takahashi, Yukina, Sakamoto, Kazuo, Manabe, Shun, Hara, Satoshi, Takashima, Yasutoshi, Dan, Takashi, Pastan, Ira, Miyata, Toshio, Kurihara, Hidetake, Matsusaka, Taiji, Reiser, Jochen, Nagata, Michio

“…Podocyte-endothelial cell cross-talk is paramount for maintaining the filtration barrier. The present study investigated the endothelial response to podocyte…”
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Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice by Nagase, Miki, Kurihara, Hidetake, Aiba, Atsu, Young, Morag J, Sakai, Tatsuo

“…Macrophage-mediated inflammation has been implicated in various kidney diseases. We previously reported that Rac1, a Rho family small GTP-binding protein, was…”
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Glomerular Endothelial Cells Form Diaphragms during Development and Pathologic Conditions by ICHIMURA, Koichiro, STAN, Radu V, KURIHARA, Hidetake, SAKAI, Tatsuo

“…Unlike most fenestrated capillary endothelial cells, adult glomerular endothelial cells (GEnC) are generally thought to lack diaphragms at their fenestrae, but…”
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Primary cilia disappear in rat podocytes during glomerular development by Ichimura, Koichiro, Kurihara, Hidetake, Sakai, Tatsuo

“…Most tubular epithelial cell types express primary cilia, and mutations of primary-cilium-associated proteins are well known to cause several kinds of cystic…”
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Phosphorylation of Nephrin Triggers Its Internalization by Raft-Mediated Endocytosis by QIN, Xiao-Song, TSUKAGUCHI, Hiroyasu, SHONO, Akemi, YAMAMOTO, Akitsugu, KURIHARA, Hidetake, DOI, Toshio

“…Proper localization of nephrin determines integrity of the glomerular slit diaphragm. Slit diaphragm proteins assemble into functional signaling complexes on a…”
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c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis by Piao, Xuehua, Komazawa-Sakon, Sachiko, Nishina, Takashi, Koike, Masato, Piao, Jiang-Hu, Ehlken, Hanno, Kurihara, Hidetake, Hara, Mutsuko, Van Rooijen, Nico, Schütz, Günther, Ohmuraya, Masaki, Uchiyama, Yasuo, Yagita, Hideo, Okumura, Ko, He, You-Wen, Nakano, Hiroyasu

“…As a catalytically inactive homolog of caspase-8, a proapoptotic initiator caspase, c-FLIP blocks apoptosis by binding to and inhibiting caspase-8. The…”
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aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface by Satoh, Daisuke, Hirose, Tomonori, Harita, Yutaka, Daimon, Chikara, Harada, Tomonori, Kurihara, Hidetake, Yamashita, Akio, Ohno, Shigeo

“…The slit diaphragm (SD), the specialized intercellular junction between renal glomerular epithelial cells (podocytes), provides a selective-filtration barrier…”
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Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth by Ichikawa, Naoki, Iwabuchi, Kazuhisa, Kurihara, Hidetake, Ishii, Kumiko, Kobayashi, Toshihide, Sasaki, Takako, Hattori, Nobutaka, Mizuno, Yoshikuni, Hozumi, Kentaro, Yamada, Yoshihiko, Arikawa-Hirasawa, Eri

“…Laminin-1, an extracellular matrix molecule, promotes neurite outgrowth through the interaction of integrin and actin. Monosialoganglioside GM1 in the lipid…”
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Mesenchymal stem cell transplantation to the mouse cochlea as a treatment for childhood sensorineural hearing loss by Kasagi, Hiromi, Kuhara, Takatoshi, Okada, Hiroko, Sueyoshi, Noriyoshi, Kurihara, Hidetake

“…Abstract Objective There is no treatment established for congenital sensorineural hearing loss because the majority of the cases are hereditary. Although…”
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Neph1, a Component of the Kidney Slit Diaphragm, Is Tyrosine-phosphorylated by the Src Family Tyrosine Kinase and Modulates Intracellular Signaling by Binding to Grb2 by Harita, Yutaka, Kurihara, Hidetake, Kosako, Hidetaka, Tezuka, Tohru, Sekine, Takashi, Igarashi, Takashi, Hattori, Seisuke

“…There are several lines of evidence that the podocyte slit diaphragm (SD), which serves as a structural framework for the filtration barrier in kidney…”
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UNC119 is a binding partner of tumor suppressor Ras‐association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53 by Iwasa, Hiroaki, Sarkar, Aradhan, Shimizu, Takanobu, Sawada, Takeru, Hossain, Shakhawoat, Xu, Xiaoyin, Maruyama, Junichi, Arimoto‐Matsuzaki, Kyoko, Withanage, Kanchanamala, Nakagawa, Kentaro, Kurihara, Hidetake, Kuroyanagi, Hidehito, Hata, Yutaka

“…Ras‐association domain family 6 (RASSF6) is a tumor suppressor that interacts with MDM2 and stabilizes p53. Caenorhabditis elegans unc‐119 encodes a protein…”
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