Search Results - "Kurie, Jonathan M"

Smoking, p53 mutation, and lung cancer by Gibbons, Don L, Byers, Lauren A, Kurie, Jonathan M

“…This issue marks the 50th anniversary of the release of the U.S. Surgeon General's Report on Smoking and Health. Perhaps no other singular event has done more…”
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Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion by Peng, David H., Rodriguez, Bertha Leticia, Diao, Lixia, Chen, Limo, Wang, Jing, Byers, Lauren A., Wei, Ying, Chapman, Harold A., Yamauchi, Mitsuo, Behrens, Carmen, Raso, Gabriela, Soto, Luisa Maren Solis, Cuentes, Edwin Roger Parra, Wistuba, Ignacio I., Kurie, Jonathan M., Gibbons, Don L.

“…Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling reveal increased collagen levels…”
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Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression by Gibbons, Don L, Lin, Wei, Creighton, Chad J, Rizvi, Zain H, Gregory, Philip A, Goodall, Gregory J, Thilaganathan, Nishan, Du, Liqin, Zhang, Yiqun, Pertsemlidis, Alexander, Kurie, Jonathan M

“…Metastatic disease is a primary cause of cancer-related death, and factors governing tumor cell metastasis have not been fully elucidated. Here, we address…”
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EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer by Tan, Xiaochao, Xiao, Guan-Yu, Wang, Shike, Shi, Lei, Zhao, Yanbin, Liu, Xin, Yu, Jiang, Russell, William K, Creighton, Chad J, Kurie, Jonathan M

“…Hypersecretory malignant cells underlie therapeutic resistance, metastasis, and poor clinical outcomes. However, the molecular basis for malignant…”
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BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells by Kim, Jeong Seon, Kurie, Jonathan M, Ahn, Young-Ho

“…MicroRNA-200 (miR-200) suppresses the epithelial-mesenchymal transition of various cancer cells, including lung adenocarcinoma cells. We found that bone…”
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Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers by Kawakami, Masanori, Mustachio, Lisa Maria, Zheng, Lin, Chen, Yulong, Rodriguez-Canales, Jaime, Mino, Barbara, Kurie, Jonathan M., Roszik, Jason, Villalobos, Pamela Andrea, Thu, Kelsie L., Silvester, Jennifer, Cescon, David W., Wistuba, Ignacio I., Mak, Tak W., Liu, Xi, Dmitrovsky, Ethan

“…Polo-like kinase 4 (PLK4) is a serine/threonine kinase regulating centriole duplication. CFI-400945 is a highly selective PLK4 inhibitor that deregulates…”
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JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer by Shien, Kazuhiko, Papadimitrakopoulou, Vassiliki A, Ruder, Dennis, Behrens, Carmen, Shen, Li, Kalhor, Neda, Song, Juhee, Lee, J Jack, Wang, Jing, Tang, Ximing, Herbst, Roy S, Toyooka, Shinichi, Girard, Luc, Minna, John D, Kurie, Jonathan M, Wistuba, Ignacio I, Izzo, Julie G

“…Molecularly targeted drugs have yielded significant therapeutic advances in oncogene-driven non-small cell lung cancer (NSCLC), but a majority of patients…”
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Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma by Pankova, Daniela, Chen, Yulong, Terajima, Masahiko, Schliekelman, Mark J, Baird, Brandi N, Fahrenholtz, Monica, Sun, Li, Gill, Bartley J, Vadakkan, Tegy J, Kim, Min P, Ahn, Young-Ho, Roybal, Jonathon D, Liu, Xin, Parra Cuentas, Edwin Roger, Rodriguez, Jaime, Wistuba, Ignacio I, Creighton, Chad J, Gibbons, Don L, Hicks, John M, Dickinson, Mary E, West, Jennifer L, Grande-Allen, K Jane, Hanash, Samir M, Yamauchi, Mitsuo, Kurie, Jonathan M

“…Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how collagen cross-linking is regulated in…”
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The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells by Banerjee, Priyam, Xiao, Guan-Yu, Tan, Xiaochao, Zheng, Veronica J., Shi, Lei, Rabassedas, Maria Neus Bota, Guo, Hou-fu, Liu, Xin, Yu, Jiang, Diao, Lixia, Wang, Jing, Russell, William K., Roszik, Jason, Creighton, Chad J., Kurie, Jonathan M.

“…Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which cancer cells establish a front-rear polarity axis that facilitates…”
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Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3–amplified lung adenocarcinoma cells by Shi, Lei, Tan, Xiaochao, Liu, Xin, Yu, Jiang, Bota-Rabassedas, Neus, Niu, Yichi, Luo, Jiayi, Xi, Yuanxin, Zong, Chenghang, Creighton, Chad J., Glenn, Jeffrey S., Wang, Jing, Kurie, Jonathan M.

“…A chromosome 1q21.3 region that is frequently amplified in diverse cancer types encodes phosphatidylinositol (PI)-4 kinase IIIβ (PI4KIIIβ), a key regulator of…”
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The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth by Liu, Xi, Lu, Yun, Chen, Zibo, Liu, Xiuxia, Hu, Weiguo, Zheng, Lin, Chen, Yulong, Kurie, Jonathan M, Shi, Mi, Mustachio, Lisa Maria, Adresson, Thorkell, Fox, Stephen, Roszik, Jason, Kawakami, Masanori, Freemantle, Sarah J, Dmitrovsky, Ethan

“…Ubiquitin specific peptidase 18 (USP18), previously known as UBP43, is the IFN-stimulated gene 15 (ISG15) deconjugase. USP18 removes ISG15 from substrate…”
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Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes by Terajima, Masahiko, Taga, Yuki, Nakamura, Tomoyuki, Guo, Hou-Fu, Kayashima, Yukako, Maeda-Smithies, Nobuyo, Parag-Sharma, Kshitij, Kim, Jeong Seon, Amelio, Antonio L., Mizuno, Kazunori, Kurie, Jonathan M., Yamauchi, Mitsuo

“…Lysyl hydroxylase 2 (LH2) is a member of LH family that catalyzes the hydroxylation of lysine (Lys) residues on collagen, and this particular isozyme has been…”
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MiR-34a and miR-34b/c have distinct effects on the suppression of lung adenocarcinomas by Kim, Jeong Seon, Kim, Eun Ju, Lee, Sieun, Tan, Xiaochao, Liu, Xin, Park, Sanghui, Kang, Keunsoo, Yoon, Jung-Sook, Ko, Yoon Ho, Kurie, Jonathan M., Ahn, Young-Ho

“…Three miR-34 family members (miR-34a, miR-34b, and miR-34c) are clustered on two different chromosomal loci, Mir34a and Mir34b/c . These miRNAs have identical…”
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The miR-195 Axis Regulates Chemoresistance through TUBB and Lung Cancer Progression through BIRC5 by Yu, Xiaojie, Zhang, Yiqiang, Wu, Binggen, Kurie, Jonathan M., Pertsemlidis, Alexander

“…Chemoresistance and metastasis are the major reasons for non-small cell lung cancer (NSCLC) treatment failure and patient deaths. We and others have shown that…”
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The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice by Yang, Yanan, Ahn, Young-Ho, Gibbons, Don L, Zang, Yi, Lin, Wei, Thilaganathan, Nishan, Alvarez, Cristina A, Moreira, Daniel C, Creighton, Chad J, Gregory, Philip A, Goodall, Gregory J, Kurie, Jonathan M

“…Epithelial tumor cells transit to a mesenchymal state in response to extracellular cues, in a process known as epithelial-to-mesenchymal transition (EMT). The…”
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Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen by Terajima, Masahiko, Taga, Yuki, Chen, Yulong, Cabral, Wayne A., Hou-Fu, Guo, Srisawasdi, Sirivimol, Nagasawa, Masako, Sumida, Noriko, Hattori, Shunji, Kurie, Jonathan M., Marini, Joan C., Yamauchi, Mitsuo

“…Covalent intermolecular cross-linking provides collagen fibrils with stability. The cross-linking chemistry is tissue-specific and determined primarily by the…”
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CXCR2 Expression in Tumor Cells is a Poor Prognostic Factor and Promotes Invasion and Metastasis in Lung Adenocarcinoma by SAINTIGNY, Pierre, MASSARELLI, Erminia, LIZHANG, YUAN PING, BEHRENS, Carmen, SOLIS SOTO, Luisa M, HEYMACH, John V, KIM, Edward S, HERBST, Roy S, LIPPMAN, Scott M, WISTUBA, Ignacio I, KI HONG, Waun, LIN, Steven, KURIE, Jonathan M, JA SEOK KOO, AHN, Young-Ho, YULONG CHEN, GOSWAMI, Sangeeta, EREZ, Baruch, O'REILLY, Michael S, DIANELIU, JACK LEE, J

“…CXCR2 in non-small cell lung cancer (NSCLC) has been studied mainly in stromal cells and is known to increase tumor inflammation and angiogenesis. Here, we…”
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Targets of the Tumor Suppressor miR-200 in Regulation of the Epithelial-Mesenchymal Transition in Cancer by SCHLIEKELMAN, Mark J, GIBBONS, Don L, SHIN, Dong-Hoon, KURIE, Jonathan M, HANASH, Samir M, FACA, Vitor M, CREIGHTON, Chad J, RIZVI, Zain H, QING ZHANG, WONG, Chee-Hong, HONG WANG, UNGEWISS, Christin, AHN, Young-Ho

“…The microRNA-200 (miR-200) family restricts epithelial-mesenchymal transition (EMT) and metastasis in tumor cell lines derived from mice that develop…”
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Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding by Guo, Hou-Fu, Tsai, Chi-Lin, Terajima, Masahiko, Tan, Xiaochao, Banerjee, Priyam, Miller, Mitchell D., Liu, Xin, Yu, Jiang, Byemerwa, Jovita, Alvarado, Sarah, Kaoud, Tamer S., Dalby, Kevin N., Bota-Rabassedas, Neus, Chen, Yulong, Yamauchi, Mitsuo, Tainer, John A., Phillips, George N., Kurie, Jonathan M.

“…Collagen lysyl hydroxylases (LH1-3) are Fe 2+ - and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels…”
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Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis by Chen, Zibo, Zheng, Lin, Chen, Yulong, Liu, Xiuxia, Kawakami, Masanori, Mustachio, Lisa Maria, Roszik, Jason, Ferry-Galow, Katherine V., Parchment, Ralph E., Liu, Xin, Andresson, Thorkell, Duncan, Gerard, Kurie, Jonathan M., Rodriguez-Canales, Jaime, Liu, Xi, Dmitrovsky, Ethan

“…Cancer metastasis is a major cause of cancer-related mortality. Strategies to reduce metastases are needed especially in lung cancer, the most common cause of…”
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