Search Results - "Kurie, Jonathan"

The fibrotic tumor stroma by Yamauchi, Mitsuo, Barker, Thomas H, Gibbons, Don L, Kurie, Jonathan M

“…Intratumoral fibrosis results from the deposition of a cross-linked collagen matrix by cancer-associated fibroblasts (CAFs). This type of fibrosis has been…”
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Smoking, p53 mutation, and lung cancer by Gibbons, Don L, Byers, Lauren A, Kurie, Jonathan M

“…This issue marks the 50th anniversary of the release of the U.S. Surgeon General's Report on Smoking and Health. Perhaps no other singular event has done more…”
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Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion by Peng, David H., Rodriguez, Bertha Leticia, Diao, Lixia, Chen, Limo, Wang, Jing, Byers, Lauren A., Wei, Ying, Chapman, Harold A., Yamauchi, Mitsuo, Behrens, Carmen, Raso, Gabriela, Soto, Luisa Maren Solis, Cuentes, Edwin Roger Parra, Wistuba, Ignacio I., Kurie, Jonathan M., Gibbons, Don L.

“…Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling reveal increased collagen levels…”
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The cancer-associated secretory phenotype: a new frontier in targeted therapeutics by Tan, Xiaochao, Xiao, Guan-Yu, Banerjee, Priyam, Wang, Shike, Kurie, Jonathan M

“…Tan discusses the cancer-associated secretory phenotypes (CASPs). Somatic mutations activate CASPs by initiating cargo-specific secretory vesicle biogenesis in…”
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Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression by Chen, Limo, Gibbons, Don L., Goswami, Sangeeta, Cortez, Maria Angelica, Ahn, Young-Ho, Byers, Lauren A., Zhang, Xuejun, Yi, Xiaohui, Dwyer, David, Lin, Wei, Diao, Lixia, Wang, Jing, Roybal, Jonathon D., Patel, Mayuri, Ungewiss, Christin, Peng, David, Antonia, Scott, Mediavilla-Varela, Melanie, Robertson, Gordon, Jones, Steve, Suraokar, Milind, Welsh, James W., Erez, Baruch, Wistuba, Ignacio I., Chen, Lieping, Peng, Di, Wang, Shanshan, Ullrich, Stephen E., Heymach, John V., Kurie, Jonathan M., Qin, F. Xiao-Feng

“…Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We…”
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Fibroblast heterogeneity and its impact on extracellular matrix and immune landscape remodeling in cancer by Yamauchi, Mitsuo, Gibbons, Don L., Zong, Chenghang, Fradette, Jared J., Bota-Rabassedas, Neus, Kurie, Jonathan M.

“…Tumor progression is marked by dense collagenous matrix accumulations that dynamically reorganize to accommodate a growing and invasive tumor mass…”
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Analysis of Golgi Secretory Functions in Cancer by Banerjee, Priyam, Tan, Xiaochao, Russell, William K, Kurie, Jonathan M

“…Cancer cells utilize secretory pathways for paracrine signaling and extracellular matrix remodeling to facilitate directional cell migration, invasion, and…”
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Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression by Gibbons, Don L, Lin, Wei, Creighton, Chad J, Rizvi, Zain H, Gregory, Philip A, Goodall, Gregory J, Thilaganathan, Nishan, Du, Liqin, Zhang, Yiqun, Pertsemlidis, Alexander, Kurie, Jonathan M

“…Metastatic disease is a primary cause of cancer-related death, and factors governing tumor cell metastasis have not been fully elucidated. Here, we address…”
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EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer by Tan, Xiaochao, Xiao, Guan-Yu, Wang, Shike, Shi, Lei, Zhao, Yanbin, Liu, Xin, Yu, Jiang, Russell, William K, Creighton, Chad J, Kurie, Jonathan M

“…Hypersecretory malignant cells underlie therapeutic resistance, metastasis, and poor clinical outcomes. However, the molecular basis for malignant…”
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BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells by Kim, Jeong Seon, Kurie, Jonathan M, Ahn, Young-Ho

“…MicroRNA-200 (miR-200) suppresses the epithelial-mesenchymal transition of various cancer cells, including lung adenocarcinoma cells. We found that bone…”
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Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers by Kawakami, Masanori, Mustachio, Lisa Maria, Zheng, Lin, Chen, Yulong, Rodriguez-Canales, Jaime, Mino, Barbara, Kurie, Jonathan M., Roszik, Jason, Villalobos, Pamela Andrea, Thu, Kelsie L., Silvester, Jennifer, Cescon, David W., Wistuba, Ignacio I., Mak, Tak W., Liu, Xi, Dmitrovsky, Ethan

“…Polo-like kinase 4 (PLK4) is a serine/threonine kinase regulating centriole duplication. CFI-400945 is a highly selective PLK4 inhibitor that deregulates…”
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JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer by Shien, Kazuhiko, Papadimitrakopoulou, Vassiliki A, Ruder, Dennis, Behrens, Carmen, Shen, Li, Kalhor, Neda, Song, Juhee, Lee, J Jack, Wang, Jing, Tang, Ximing, Herbst, Roy S, Toyooka, Shinichi, Girard, Luc, Minna, John D, Kurie, Jonathan M, Wistuba, Ignacio I, Izzo, Julie G

“…Molecularly targeted drugs have yielded significant therapeutic advances in oncogene-driven non-small cell lung cancer (NSCLC), but a majority of patients…”
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Phase II Trial of Concurrent Atezolizumab With Chemoradiation for Unresectable NSCLC by Lin, Steven H, Lin, Yan, Yao, Luyang, Kalhor, Neda, Carter, Brett W, Altan, Mehmet, Blumenschein, George, Byers, Lauren A, Fossella, Frank, Gibbons, Don L, Kurie, Jonathan M, Lu, Charles, Simon, George, Skoulidis, Ferdinandos, Chang, Joe Y, Jeter, Melenda D, Liao, Zhongxing, Gomez, Daniel R, O'Reilly, Michael, Papadimitrakopoulou, Vali, Thall, Peter, Heymach, John V, Tsao, Anne S

“…Consolidation durvalumab after chemoradiation (CRT) is the current standard of care for locally advanced NSCLC. We hypothesized that adding immunotherapy…”
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Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma by Pankova, Daniela, Chen, Yulong, Terajima, Masahiko, Schliekelman, Mark J, Baird, Brandi N, Fahrenholtz, Monica, Sun, Li, Gill, Bartley J, Vadakkan, Tegy J, Kim, Min P, Ahn, Young-Ho, Roybal, Jonathon D, Liu, Xin, Parra Cuentas, Edwin Roger, Rodriguez, Jaime, Wistuba, Ignacio I, Creighton, Chad J, Gibbons, Don L, Hicks, John M, Dickinson, Mary E, West, Jennifer L, Grande-Allen, K Jane, Hanash, Samir M, Yamauchi, Mitsuo, Kurie, Jonathan M

“…Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how collagen cross-linking is regulated in…”
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The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells by Banerjee, Priyam, Xiao, Guan-Yu, Tan, Xiaochao, Zheng, Veronica J., Shi, Lei, Rabassedas, Maria Neus Bota, Guo, Hou-fu, Liu, Xin, Yu, Jiang, Diao, Lixia, Wang, Jing, Russell, William K., Roszik, Jason, Creighton, Chad J., Kurie, Jonathan M.

“…Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which cancer cells establish a front-rear polarity axis that facilitates…”
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A Method for Orthotopic Transplantation of Lung Cancer in Mice by Wilson, Alexandra N, Chen, Baozhi, Liu, Xin, Kurie, Jonathan M, Kim, James

“…Preclinical mouse models of lung cancer have been vital experimental tools to elucidate cancer biology and test novel therapeutic regimens. Two main models are…”
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Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3–amplified lung adenocarcinoma cells by Shi, Lei, Tan, Xiaochao, Liu, Xin, Yu, Jiang, Bota-Rabassedas, Neus, Niu, Yichi, Luo, Jiayi, Xi, Yuanxin, Zong, Chenghang, Creighton, Chad J., Glenn, Jeffrey S., Wang, Jing, Kurie, Jonathan M.

“…A chromosome 1q21.3 region that is frequently amplified in diverse cancer types encodes phosphatidylinositol (PI)-4 kinase IIIβ (PI4KIIIβ), a key regulator of…”
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The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth by Liu, Xi, Lu, Yun, Chen, Zibo, Liu, Xiuxia, Hu, Weiguo, Zheng, Lin, Chen, Yulong, Kurie, Jonathan M, Shi, Mi, Mustachio, Lisa Maria, Adresson, Thorkell, Fox, Stephen, Roszik, Jason, Kawakami, Masanori, Freemantle, Sarah J, Dmitrovsky, Ethan

“…Ubiquitin specific peptidase 18 (USP18), previously known as UBP43, is the IFN-stimulated gene 15 (ISG15) deconjugase. USP18 removes ISG15 from substrate…”
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Programmed Death-Ligand 1 Heterogeneity and Its Impact on Benefit From Immune Checkpoint Inhibitors in NSCLC by Hong, Lingzhi, Negrao, Marcelo V, Dibaj, Seyedeh S, Chen, Runzhe, Reuben, Alexandre, Bohac, Jadi M, Liu, Xiaoke, Skoulidis, Ferdinandos, Gay, Carl M, Cascone, Tina, Mitchell, Kyle G, Tran, Hai T, Le, Xiuning, Byers, Lauren A, Sepesi, Boris, Altan, Mehmet, Elamin, Yasir Y, Fossella, Frank V, Kurie, Jonathan M, Lu, Charles, Mott, Frank E, Tsao, Anne S, Rinsurongkawong, Waree, Lewis, Jeff, Gibbons, Don L, Glisson, Bonnie S, Blumenschein, Jr, George R, Roarty, Emily B, Futreal, P Andrew, Wistuba, Ignacio I, Roth, Jack A, Swisher, Stephen G, Papadimitrakopoulou, Vassiliki A, Heymach, John V, Lee, J Jack, Simon, George R, Zhang, Jianjun

“…Programmed death-ligand 1 (PD-L1) expression may vary in different disease sites and at different time points of the disease course. We aimed to investigate…”
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Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11 by Tan, Xiaochao, Banerjee, Priyam, Guo, Hou-Fu, Ireland, Stephen, Pankova, Daniela, Ahn, Young-Ho, Nikolaidis, Irodotos Michail, Liu, Xin, Zhao, Yanbin, Xue, Yongming, Burns, Alan R, Roybal, Jonathon, Gibbons, Don L, Zal, Tomasz, Creighton, Chad J, Ungar, Daniel, Wang, Yanzhuang, Kurie, Jonathan M

“…Tumor cells gain metastatic capacity through a Golgi phosphoprotein 3-dependent (GOLPH3-dependent) Golgi membrane dispersal process that drives the budding and…”
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