Search Results - "Kurian, S M"

Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs by Roseberry, K., Le-Niculescu, H., Levey, D. F., Bhagar, R., Soe, K., Rogers, J., Palkowitz, S., Pina, N., Anastasiadis, W. A., Gill, S. S., Kurian, S. M., Shekhar, A., Niculescu, A. B.

“…Anxiety disorders are increasingly prevalent, affect people’s ability to do things, and decrease quality of life. Due to lack of objective tests, they are…”
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Precision medicine for psychotic disorders: objective assessment, risk prediction, and pharmacogenomics by Hill, M. D., Gill, S. S., Le-Niculescu, H., MacKie, O., Bhagar, R., Roseberry, K., Murray, O. K., Dainton, H. D., Wolf, S. K., Shekhar, A., Kurian, S. M., Niculescu, A. B.

“…Psychosis occurs inside the brain, but may have external manifestations (peripheral molecular biomarkers, behaviors) that can be objectively and quantitatively…”
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Next-generation precision medicine for suicidality prevention by Bhagar, R., Gill, S. S., Le-Niculescu, H., Yin, C., Roseberry, K., Mullen, J., Schmitz, M., Paul, E., Cooke, J., Tracy, C., Tracy, Z., Gettelfinger, A. S., Battles, D., Yard, M., Sandusky, G., Shekhar, A., Kurian, S. M., Bogdan, P., Niculescu, A. B.

“…Suicidality remains a clear and present danger in society in general, and for mental health patients in particular. Lack of widespread use of objective and/or…”
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Identification of blood biomarkers for psychosis using convergent functional genomics by Kurian, S M, Le-Niculescu, H, Patel, S D, Bertram, D, Davis, J, Dike, C, Yehyawi, N, Lysaker, P, Dustin, J, Caligiuri, M, Lohr, J, Lahiri, D K, Nurnberger, J I, Faraone, S V, Geyer, M A, Tsuang, M T, Schork, N J, Salomon, D R, Niculescu, A B

“…There are to date no objective clinical laboratory blood tests for psychotic disease states. We provide proof of principle for a convergent functional genomics…”
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Molecular Classifiers for Acute Kidney Transplant Rejection in Peripheral Blood by Whole Genome Gene Expression Profiling by Kurian, S. M., Williams, A. N., Gelbart, T., Campbell, D., Mondala, T. S., Head, S. R., Horvath, S., Gaber, L., Thompson, R., Whisenant, T., Lin, W., Langfelder, P., Robison, E. H., Schaffer, R. L., Fisher, J. S., Friedewald, J., Flechner, S. M., Chan, L. K., Wiseman, A. C., Shidban, H., Mendez, R., Heilman, R., Abecassis, M. M., Marsh, C. L., Salomon, D. R.

“…There are no minimally invasive diagnostic metrics for acute kidney transplant rejection (AR), especially in the setting of the common confounding diagnosis,…”
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Clinical and Plasma Proteomic Markers Correlating With Chronic Kidney Disease After Liver Transplantation by Levitsky, J., Salomon, D. R., Abecassis, M., Langfelder, P., Horvath, S., Friedewald, J., Wang, E., Kurian, S. M., Mondala, T., Gil, S., McDade, R., Ballard, K., Gallon, L.

“…Chronic kidney disease (CKD) occurs frequently after liver transplantation (LT) and is associated with significant morbidity and mortality. Thus, there is a…”
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Identifying blood biomarkers for mood disorders using convergent functional genomics by Le-Niculescu, H, Kurian, S M, Yehyawi, N, Dike, C, Patel, S D, Edenberg, H J, Tsuang, M T, Salomon, D R, Nurnberger, J I, Niculescu, A B

“…There are to date no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the…”
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Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs by Le-Niculescu, H., Roseberry, K., Gill, S. S., Levey, D. F., Phalen, P. L., Mullen, J., Williams, A., Bhairo, S., Voegtline, T., Davis, H., Shekhar, A., Kurian, S. M., Niculescu, A. B.

“…Mood disorders (depression, bipolar disorders) are prevalent and disabling. They are also highly co-morbid with other psychiatric disorders. Currently there…”
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Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs by Niculescu, A. B., Le-Niculescu, H., Roseberry, K., Wang, S., Hart, J., Kaur, A., Robertson, H., Jones, T., Strasburger, A., Williams, A., Kurian, S. M., Lamb, B., Shekhar, A., Lahiri, D. K., Saykin, A. J.

“…Short-term memory dysfunction is a key early feature of Alzheimer’s disease (AD). Psychiatric patients may be at higher risk for memory dysfunction and…”
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Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs by Niculescu, A. B., Le-Niculescu, H., Levey, D. F., Roseberry, K., Soe, K. C., Rogers, J., Khan, F., Jones, T., Judd, S., McCormick, M. A., Wessel, A. R., Williams, A., Kurian, S. M., White, F. A.

“…We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization,…”
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Transplanting Kidneys from Deceased Donors With Severe Acute Kidney Injury by Heilman, R. L., Smith, M. L., Kurian, S. M., Huskey, J., Batra, R. K., Chakkera, H. A., Katariya, N. N., Khamash, H., Moss, A., Salomon, D. R., Reddy, K. S.

“…Our aim was to determine outcomes with transplanting kidneys from deceased donors with acute kidney injury, defined as a donor with terminal serum creatinine…”
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Precision medicine for suicidality: from universality to subtypes and personalization by Niculescu, A B, Le-Niculescu, H, Levey, D F, Phalen, P L, Dainton, H L, Roseberry, K, Niculescu, E M, Niezer, J O, Williams, A, Graham, D L, Jones, T J, Venugopal, V, Ballew, A, Yard, M, Gelbart, T, Kurian, S M, Shekhar, A, Schork, N J, Sandusky, G E, Salomon, D R

“…Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in…”
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Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs by Le-Niculescu, H., Roseberry, K., Levey, D. F., Rogers, J., Kosary, K., Prabha, S., Jones, T., Judd, S., McCormick, M. A, Wessel, A. R., Williams, A., Phalen, P. L., Mamdani, F., Sequeira, A., Kurian, S. M., Niculescu, A. B.

“…The biological fingerprint of environmental adversity may be key to understanding health and disease, as it encompasses the damage induced as well as the…”
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Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions by Niculescu, A B, Levey, D, Le-Niculescu, H, Niculescu, E, Kurian, S M, Salomon, D

“…Blood biomarkers may provide a scientifically useful and clinically usable peripheral signal in psychiatry, as they have been doing for other fields of…”
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Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach by Niculescu, A B, Levey, D F, Phalen, P L, Le-Niculescu, H, Dainton, H D, Jain, N, Belanger, E, James, A, George, S, Weber, H, Graham, D L, Schweitzer, R, Ladd, T B, Learman, R, Niculescu, E M, Vanipenta, N P, Khan, F N, Mullen, J, Shankar, G, Cook, S, Humbert, C, Ballew, A, Yard, M, Gelbart, T, Shekhar, A, Schork, N J, Kurian, S M, Sandusky, G E, Salomon, D R

“…Worldwide, one person dies every 40 seconds by suicide, a potentially preventable tragedy. A limiting step in our ability to intervene is the lack of…”
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Discovery and validation of blood biomarkers for suicidality by Le-Niculescu, H, Levey, D F, Ayalew, M, Palmer, L, Gavrin, L M, Jain, N, Winiger, E, Bhosrekar, S, Shankar, G, Radel, M, Bellanger, E, Duckworth, H, Olesek, K, Vergo, J, Schweitzer, R, Yard, M, Ballew, A, Shekhar, A, Sandusky, G E, Schork, N J, Kurian, S M, Salomon, D R, Niculescu, A B

“…Suicides are a leading cause of death in psychiatric patients, and in society at large. Developing more quantitative and objective ways (biomarkers) for…”
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Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long‐Term Outcomes by Modena, B. D., Kurian, S. M., Gaber, L. W., Waalen, J., Su, A. I., Gelbart, T., Mondala, T. S., Head, S. R., Papp, S., Heilman, R., Friedewald, J. J., Flechner, S. M., Marsh, C. L., Sung, R. S., Shidban, H., Chan, L., Abecassis, M. M., Salomon, D. R.

“…Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1‐year biopsies posttransplant. It is known that IFTA correlates with…”
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Vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms in spinal tuberculosis by Selvaraj, P, Kurian, SM, Chandra, G, Reetha, AM, Charles, N, Narayanan, PR

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Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment by Levey, D F, Niculescu, E M, Le-Niculescu, H, Dainton, H L, Phalen, P L, Ladd, T B, Weber, H, Belanger, E, Graham, D L, Khan, F N, Vanipenta, N P, Stage, E C, Ballew, A, Yard, M, Gelbart, T, Shekhar, A, Schork, N J, Kurian, S M, Sandusky, G E, Salomon, D R, Niculescu, A B

“…Women are under-represented in research on suicidality to date. Although women have a lower rate of suicide completion than men, due in part to the…”
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Orthogonal Comparison of Molecular Signatures of Kidney Transplants With Subclinical and Clinical Acute Rejection: Equivalent Performance Is Agnostic to Both Technology and Platform by Kurian, S. M., Velazquez, E., Thompson, R., Whisenant, T., Rose, S., Riley, N., Harrison, F., Gelbart, T., Friedewald, J. J., charette, j., Brietigam, S., Peysakhovich, J., First, M. R., Abecassis, M. M., Salomon, D. R.

“…We performed orthogonal technology comparisons of concurrent peripheral blood and biopsy tissue samples from 69 kidney transplant recipients who underwent…”
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