Search Results - "Kurhade, Santosh H"

Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia by Deshpande, Anil M., Bhuniya, Debnath, De, Siddhartha, Dave, Bhavesh, Vyavahare, Vinod P., Kurhade, Santosh H., Kandalkar, Sachin R., Naik, Keshav P., Kobal, Balasaheb S., Kaduskar, Rahul D., Basu, Sujay, Jain, Vaibhav, Patil, Pratima, Chaturvedi Joshi, Sandhya, Bhat, Ganesh, Raje, Amol A., Reddy, Satyanarayana, Gundu, Jayasagar, Madgula, Vamsi, Tambe, Suhas, Shitole, Prasad, Umrani, Dhananjay, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A.

“…Glucokinase activators (GKAs) are among the emerging drug candidates for the treatment of type 2 diabetes (T2D). Despite effective blood glucose lowering in…”
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Pharmacological screening identifies SHK242 and SHK277 as novel arginase inhibitors with efficacy against allergen-induced airway narrowing in vitro and in vivo by Van den Berg, Mariska P M, Kurhade, Santosh H, Maarsingh, Harm, Erceg, Stefanie, Hulsbeek, Imke R, Boekema, Pieter H, Kistemaker, Loes E M, van Faassen, Martijn, Kema, Ido P, Elsinga, Philip H, Dömling, Alex S S, Meurs, Herman, Gosens, Reinoud

“…Arginase is a potential target for asthma treatment. However, currently there are no arginase inhibitors available for clinical use. Here a novel class of…”
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