Search Results - "Kurata, Tatsuaki"

A widespread toxin−antitoxin system exploiting growth control via alarmone signaling by Jimmy, Steffi, Saha, Chayan Kumar, Kurata, Tatsuaki, Stavropoulos, Constantine, Oliveira, Sofia Raquel Alves, Koh, Alan, Cepauskas, Albinas, Takada, Hiraku, Rejman, Dominik, Tenson, Tanel, Strahl, Henrik, Garcia-Pino, Abel, Hauryliuk, Vasili, Гаврилюк, Василий, Atkinson, Gemma C.

“…Under stressful conditions, bacterial RelA-SpoT Homolog (RSH) enzymes synthesize the alarmone (p)ppGpp, a nucleotide second messenger. (p)ppGpp rewires…”
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RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis by Kurata, Tatsuaki, Brodiazhenko, Tetiana, Alves Oliveira, Sofia Raquel, Roghanian, Mohammad, Sakaguchi, Yuriko, Turnbull, Kathryn Jane, Bulvas, Ondřej, Takada, Hiraku, Tamman, Hedvig, Ainelo, Andres, Pohl, Radek, Rejman, Dominik, Tenson, Tanel, Suzuki, Tsutomu, Garcia-Pino, Abel, Atkinson, Gemma Catherine, Hauryliuk, Vasili

“…RelA-SpoT Homolog (RSH) enzymes control bacterial physiology through synthesis and degradation of the nucleotide alarmone (p)ppGpp. We recently discovered…”
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Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes by Koller, Timm O, Turnbull, Kathryn J, Vaitkevicius, Karolis, Crowe-McAuliffe, Caillan, Roghanian, Mohammad, Bulvas, Ondřej, Nakamoto, Jose A, Kurata, Tatsuaki, Julius, Christina, Atkinson, Gemma C, Johansson, Jörgen, Hauryliuk, Vasili, Wilson, Daniel N

“…Abstract HflX is a ubiquitous bacterial GTPase that splits and recycles stressed ribosomes. In addition to HflX, Listeria monocytogenes contains a second HflX…”
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Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp by Takada, Hiraku, Mandell, Zachary F, Yakhnin, Helen, Glazyrina, Anastasiya, Chiba, Shinobu, Kurata, Tatsuaki, Wu, Kelvin J Y, Tresco, Ben I C, Myers, Andrew G, Aktinson, Gemma C, Babitzke, Paul, Hauryliuk, Vasili

“…Since antibiotic resistance is often associated with a fitness cost, bacteria employ multi-layered regulatory mechanisms to ensure that expression of…”
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Identification of the Set of Genes, Including Nonannotated morA, under the Direct Control of ModE in Escherichia coli by Kurata, Tatsuaki, Katayama, Akira, Hiramatsu, Masakazu, Kiguchi, Yuya, Takeuchi, Masamitsu, Watanabe, Tomoyuki, Ogasawara, Hiroshi, Ishihama, Akira, Yamamoto, Kaneyoshi

“…ModE is the molybdate-sensing transcription regulator that controls the expression of genes related to molybdate homeostasis in Escherichia coli. ModE is…”
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Direct activation of a bacterial innate immune system by a viral capsid protein by Zhang, Tong, Tamman, Hedvig, Coppieters ’t Wallant, Kyo, Kurata, Tatsuaki, LeRoux, Michele, Srikant, Sriram, Brodiazhenko, Tetiana, Cepauskas, Albinas, Talavera, Ariel, Martens, Chloe, Atkinson, Gemma C., Hauryliuk, Vasili, Garcia-Pino, Abel, Laub, Michael T.

“…Bacteria have evolved diverse immunity mechanisms to protect themselves against the constant onslaught of bacteriophages 1 – 3 . Similar to how eukaryotic…”
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Mechanisms of neutralization of toxSAS from toxin-antitoxin modules by Dominguez-Molina, Lucia, Kurata, Tatsuaki, Cepauskas, Albinas, Echemendia-Blanco, Dannele, Zedek, Safia, Talavera-Perez, Ariel, Atkinson, Gemma C, Hauryliuk, Vasili, Garcia-Pino, Abel

“…Toxic small alarmone synthetase (toxSAS) enzymes constitute a family of bacterial effectors present in toxin-antitoxin and secretion systems. toxSASs act…”
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Clinically observed deletions in SARS‐CoV‐2 Nsp1 affect its stability and ability to inhibit translation by Kumar, Pravin, Schexnaydre, Erin, Rafie, Karim, Kurata, Tatsuaki, Terenin, Ilya, Hauryliuk, Vasili, Carlson, Lars‐Anders

“…Nonstructural protein 1 (Nsp1) of SARS‐CoV‐2 inhibits host cell translation through an interaction between its C‐terminal domain and the 40S ribosome. The…”
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A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains by Kurata, Tatsuaki, Saha, Chayan Kumar, Buttress, Jessica A, Mets, Toomas, Brodiazhenko, Tetiana, Turnbull, Kathryn J, Awoyomi, Ololade F, Oliveira, Sofia Raquel Alves, Jimmy, Steffi, Ernits, Karin, Delannoy, Maxence, Persson, Karina, Tenson, Tanel, Strahl, Henrik, Hauryliuk, Vasili, Atkinson, Gemma C

“…Toxin-antitoxin (TA) gene pairs are ubiquitous in microbial chromosomal genomes and plasmids as well as temperate bacteriophages. They act as regulatory…”
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A virally encoded tRNA neutralizes the PARIS antiviral defence system by Burman, Nathaniel, Belukhina, Svetlana, Depardieu, Florence, Wilkinson, Royce A, Skutel, Mikhail, Santiago-frangos, Andrew, Graham, Ava B, Livenskyi, Alexei, Chechenina, Anna, Morozova, Natalia, Zahl, Trevor, Henriques, William S, Buyukyoruk, Murat, Rouillon, Christophe, Saudemont, Baptiste, Shyrokova, Lena, Kurata, Tatsuaki, Hauryliuk, Vasili, Severinov, Konstantin, Groseille, Justine, Thierry, Agnès, Koszul, Romain, Tesson, Florian, Bernheim, Aude, Bikard, David, Wiedenheft, Blake, Isaev, Artem

“…Viruses compete with each other for limited cellular resources, and some deliver defence mechanisms that protect the host from competing genetic parasites1…”
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A virally encoded tRNA neutralizes the PARIS antiviral defence system by Burman, Nathaniel, Belukhina, Svetlana, Depardieu, Florence, Wilkinson, Royce A., Skutel, Mikhail, Santiago-Frangos, Andrew, Graham, Ava B., Livenskyi, Alexei, Chechenina, Anna, Morozova, Natalia, Zahl, Trevor, Henriques, William S., Buyukyoruk, Murat, Rouillon, Christophe, Saudemont, Baptiste, Shyrokova, Lena, Kurata, Tatsuaki, Hauryliuk, Vasili, Severinov, Konstantin, Groseille, Justine, Thierry, Agnès, Koszul, Romain, Tesson, Florian, Bernheim, Aude, Bikard, David, Wiedenheft, Blake, Isaev, Artem

“…Viruses compete with each other for limited cellular resources, and some deliver defence mechanisms that protect the host from competing genetic parasites 1 …”
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Biochemical and X-ray analyses of the players involved in the faRel 2/ aTfaRel 2 toxin–antitoxin operon by Dominguez-Molina, Lucia, Talavera, Ariel, Cepauskas, Albinas, Kurata, Tatsuaki, Echemendia-Blanco, Dannele, Hauryliuk, Vasili, Garcia-Pino, Abel

“…The aTfaRel 2/ faRel 2 operon from Coprobacillus sp. D7 encodes a bicistronic type II toxin–antitoxin (TA) module. The FaRel2 toxin is a toxic small alarmone…”
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Biochemical and X‐ray analyses of the players involved in the faRel2/aTfaRel2 toxin–antitoxin operon by Dominguez-Molina, Lucia, Talavera, Ariel, Cepauskas, Albinas, Kurata, Tatsuaki, Echemendia-Blanco, Dannele, Hauryliuk, Vasili, Garcia-Pino, Abel

“…The aTfaRel2/faRel2 operon from Coprobacillus sp. D7 encodes a bicistronic type II toxin–antitoxin (TA) module. The FaRel2 toxin is a toxic small alarmone…”
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The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems by Ernits, Karin, Saha, Chayan Kumar, Brodiazhenko, Tetiana, Chouhan, Bhanu, Shenoy, Aditi, Buttress, Jessica A, Duque-Pedraza, Julián J, Bojar, Veda, Nakamoto, Jose A, Kurata, Tatsuaki, Egorov, Artyom A, Shyrokova, Lena, Johansson, Marcus J O, Mets, Toomas, Rustamova, Aytan, Džigurski, Jelisaveta, Tenson, Tanel, Garcia-Pino, Abel, Strahl, Henrik, Elofsson, Arne, Hauryliuk, Vasili, Atkinson, Gemma C

“…Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile genetic elements. Type II TAs are encoded as…”
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Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems by Mets, Toomas, Kurata, Tatsuaki, Ernits, Karin, Johansson, Marcus J O, Craig, Sophie Z, Evora, Gabriel Medina, Buttress, Jessica A, Odai, Roni, Wallant, Kyo Coppieters't, Nakamoto, Jose A, Shyrokova, Lena, Egorov, Artyom A, Doering, Christopher Ross, Brodiazhenko, Tetiana, Laub, Michael T, Tenson, Tanel, Strahl, Henrik, Martens, Chloe, Harms, Alexander, Garcia-Pino, Abel, Atkinson, Gemma C, Hauryliuk, Vasili

“…Toxin-antitoxins (TAs) are prokaryotic two-gene systems composed of a toxin neutralized by an antitoxin. Toxin-antitoxin-chaperone (TAC) systems additionally…”
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Novel Essential Gene Involved in 16S rRNA Processing in Escherichia coli by Kurata, Tatsuaki, Nakanishi, Shinobu, Hashimoto, Masayuki, Taoka, Masato, Yamazaki, Yukiko, Isobe, Toshiaki, Kato, Jun-ichi

“…Biogenesis of ribosomes is a complex process mediated by many factors. While its transcription proceeds, ribosomal RNA (rRNA) folds itself into a…”
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Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNA Gly and tRNA Thr by Kurata, Tatsuaki, Takegawa, Masaki, Ohira, Takayuki, Syroegin, Egor A., Atkinson, Gemma C., Johansson, Marcus J.O., Polikanov, Yury S., Garcia-Pino, Abel, Suzuki, Tsutomu, Hauryliuk, Vasili

“…Translation-targeting toxic small alarmone synthetases (toxSAS) are effectors of bacterial toxin-antitoxin systems that pyrophosphorylate the 3′-CCA end of…”
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Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr by Kurata, Tatsuaki, Takegawa, Masaki, Ohira, Takayuki, Syroegin, Egor A, Atkinson, Gemma C, Johansson, Marcus J O, Polikanov, Yury S, Garcia-Pino, Abel, Suzuki, Tsutomu, Hauryliuk, Vasili

“…Translation-targeting toxic small alarmone synthetases (toxSAS) are effectors of bacterial toxin-antitoxin systems that pyrophosphorylate the 3'-CCA end of…”
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